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Estañ, María Cristina ; Calviño, Eva ; Blas, Elena de ; Boyano Adánez, María del Carmen ; Mena, María Luz ; Gómez Gómez, M.Milagros ; Rial, Eduardo ; Aller, Patricio | Elsevier | 2012While the anti-tumor efficacy of 2-deoxy-D-glucose (2-DG) is normally low in monotherapy, it may represent a valuable radio- and chemo-sensitizing agent. We here demonstrate that 2–10 mM 2-DG cooperates with arsenic trioxide (ATO) and other anti[...]texto impreso
Moraleja, I. ; Mena, María Luz ; Lázaro, A. ; Neumann, B. ; Tejedor, A. ; Jakubowski, N. ; Gómez Gómez, M.Milagros ; Esteban Fernández, D. | Elsevier | 2018Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been revealed as a convenient technique for trace elemental imaging in tissue sections, providing elemental 2D distribution at a quantitative level. For quantification p[...]texto impreso
Román, Domingo ; Pizarro, I. ; Rivera, L. ; Cámara Rica, Carmen ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros ; Solar, Carlos | SAGE | 2010Among non-cancer effects of arsenic, cardiovascular diseases have been well documented; however, few are known about the arsenic fate in cardiovascular tissues. We studied the analytic bioinorganic arsenic behaviour in cardiovascular tissues fro[...]texto impreso
Esteban Fernández, Diego ; Moreno Gordaliza, Estefanía ; Cañas, Benito ; Palacios Corvillo, M.Antonia ; Gómez Gómez, M.Milagros | RSC | 2010Pt-containing drugs are nowadays essential components in cancer chemotherapy. However, drug resistance and side effects limit the efficiency of the treatments. In order to improve the response to Pt-based drugs, different administration strategi[...]texto impreso
Aguilar Martínez, Rocío ; Gómez Gómez, M.Milagros ; Greenwood, Richard ; Mills, Graham A. ; Vrana, Branislav ; Palacios Corvillo, María A. | Elsevier | 2009A passive sampler (Chemcatcher) consisting of a 47 mm EmporeTM chelating disk (CHE) with iminodiacetic groups as the receiving phase overlaid with a diffusion membrane was developed and calibrated for the monitoring of Hg in water. Three differe[...]texto impreso
Pizarro, I. ; Roman Silva, D.A. ; Gómez Gómez, M.Milagros ; Cámara Rica, Carmen ; Palacios Corvillo, M.Antonia | Chilean Chemical Society | 2013The intracellular As-protein binding in cytosol and methanol–water extract of the auricle and saphene tissues of As impacted people was evaluated by bidimensional size exclusion FPLC-UV-ICP-MS. The fractionation of cytosol using Superdex, Phenom[...]texto impreso
Pizarro, Isabel ; Gómez Gómez, M.Milagros ; Román, Domingo ; Palacios Corvillo, M.Antonia | OMICS International | 2016Studies on the bioavailability of As, Cr, Cu, Pb, Mn and Cd of impacted soils; the As bioaccesibility in the edible parts of carrots, beets and quinoa growing in these polluted soils thought “in vitro” gastrointestinal process; the As speciation[...]texto impreso
Gómez Gómez, M.Milagros ; Rodríguez Fariñas, Nuria ; Cañas Montalvo, Benito ; Domínguez, Jorge ; Guinovart, Joan ; Cámara Rica, Carmen | Elsevier | 2011-05-30It is known that oral administration of sodium tungstate preserves the pancreatic beta cell function in diabetic rats. Healthy and streptozotocin-induced diabetic rats were treated with sodium tungstate for one, three or six weeks, after which t[...]texto impreso
Esteban Fernández, Diego ; El-Khatib, Ahmed H. ; Moraleja San José, Irene ; Gómez Gómez, M.Milagros ; Linscheid, Michael W. | ACS | 2014-12-22Molecular mass spectrometry has been applied to simultaneously obtain molecular and elemental information from metal-containing species. Energy tuning of the higher-energy collision dissociation (HCD) fragmentation cell allows the controlled pro[...]texto impreso
Aguilar Martínez, R. ; Palacios Corvillo, María Antonia ; Greenwood, R. ; Mills, G.A. ; Vrana, B. ; Gómez Gómez, M.Milagros | Elsevier | 2008An integrative passive sampler (Chemcatcher®) consisting of a 47 mm C18 Empore™ disk as the receiving phase overlaid with a thin cellulose acetate diffusion membrane was developed and calibrated for the measurement of time-weighted average water[...]texto impreso
Camano, Sonia ; Lázaro, Alberto ; Moreno Gordaliza, Estefanía ; Torres, A.M. ; Lucas, Carmen de ; Humanes, Blanca ; Lázaro, José A. ; Gómez Gómez, M.Milagros ; Bosca, Lisardo ; Tejedor, Alberto | American Society for Pharmacology and Experimental Therapeutics | 2010A major area in cancer therapy is the search for protective strategies against cisplatin-induced nephrotoxicity. We investigated the protective effect of cilastatin on cisplatininduced injury to renal proximal tubular cells. Cilastatin is a spec[...]texto impreso
Humanes, Blanca ; Lázaro, Alberto ; Camano, Sonia ; Moreno Gordaliza, Estefanía ; Lázaro, José A. ; Blanco Codesido, Montserrat ; Lara, José M. ; Ortiz, Alberto ; Gómez Gómez, M.Milagros ; Martín Vasallo, Pablo ; Tejedor, Alberto | International Society of Nephrology | 2012Cisplatin is an anticancer agent marred by nephrotoxicity; however, limiting this adverse effect may allow the use of higher doses to improve its efficacy. Cilastatin, a small molecule inhibitor of renal dehydropeptidase I, prevents proximal tub[...]texto impreso
Artiaga, G. ; Iglesias Jiménez, A. ; Moreno Gordaliza, E. ; Mena, M.L. ; Gómez Gómez, M.Milagros | Elsevier | 2019-04-30Pt-S and Pt-N interactions resulting from the coordination of cisplatin, oxaliplatin and carboplatin to two synthetic peptides that differ from each other in one amino acid (Met or His) have been thoroughly studied in this work. The degree of Pt[...]texto impreso
Aboulmagd, Sarah ; Esteban Fernández, Diego ; Moreno Gordaliza, Estefanía ; Neumann, Boris ; El-Khatib, A.H. ; Lázaro, Alberto ; Tejedor, Alberto ; Gómez Gómez, M.Milagros ; Linscheid, Michael W. | ACS | 2017The quest for internal standards useful in MALDI imaging studies goes on to get not only lateral distribution but also reliable relative quantitative information. We developed a method based on application of matrix and dual internal standards t[...]texto impreso
Pizarro, Isabel ; Artiaga, Gema ; Gómez Gómez, M.Milagros ; Palacios Corvillo, M.Antonia | Asian Journal of Science and Technology | 2018Arsenic in the Antofagasta Region of Chile is worldwide recognized as highly As contaminated area. Due to its abundance, mainly as As (V) and As (III), certain microorganisms such as several types of bacteria have evolved and developed the neces[...]
