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Montes-Casado, María ; Sanvicente, Adrián ; Casarrubios Molina, Laura ; Feito Castellano, María José ; Rojo, J.M. ; Vallet Regí, María ; Arcos Navarrete, Daniel ; Portoles, Pilar ; Portolés Pérez, María Teresa | MDPI | 2020-11-05Mesoporous bioactive glass nanospheres (NanoMBGs) have high potential for clinicalapplications. However, the impact of nanoparticles on the immune system needs to be addressed. In this study, the biocompatibility of SiO2-CaO NanoMBGs was evalua[...]texto impreso
Álvarez, Rafael ; Muñoz-Piña, Sandra ; González, Maria U. ; Izquierdo-Barba, Isabel ; Fernández-Martín, Iván ; Rico, Victor J. ; Arcos Navarrete, Daniel ; García-Valenzuela, Aurelio ; Palmero, Alberto ; Vallet Regí, María ; González-Elipe, Agustín R. ; García-Martín, José R. | MDPI | 2019-08-28Based on an already tested laboratory procedure, a new magnetron sputtering methodology to simultaneously coat two-sides of large area implants (up to ~15 cm2) with Ti nanocolumns in industrial reactors has been developed. By analyzing the requi[...]texto impreso
Turdean-Ionescu, Claudia ; Stevensson, Baltzar ; Grins, Jekabs ; Izquierdo Barba, Isabel ; García, Ana ; Arcos Navarrete, Daniel ; Vallet Regí, María ; Eden, Mattias | Royal Society of Chemistry | 2015Silicate-based bioactive glasses exhibit bone-bonding properties due to the formation of a hydroxycarbonate apatite (HCA) layer at the glass surface on its contact with living tissues. This bone-healing process is triggered by ionic exchange bet[...]texto impreso
Guisasola, Eduardo ; Baeza, Alejandro ; Talelli, Marina ; Arcos Navarrete, Daniel ; Vallet Regí, María | Royal Society of Chemistry | 2016-04-25Stimuli-responsive devices are novel tools widely studied in the nanomedicine research field. In this work, magnetic-responsive mesoporous silica nanoparticles (MMSNs) were coated with an engineered thermoresponsive co-polymer. Magnetic cores ar[...]texto impreso
Matesanz Sancho, María Concepción ; Feito Castellano, María José ; Oñaderra Sánchez, Mercedes ; Ramirez Santillán, Cecilia ; Casa, Carmen da ; Arcos Navarrete, Daniel ; Vallet Regí, María ; Rojo, José María ; Portolés Pérez, María Teresa | Elsevier | 2014-02-15Hypothesis: Synthetic hydroxyapatite (HA) and Si substituted hydroxyapatite (SiHA) are calcium phosphate ceramics currently used in the field of dentistry and orthopaedic surgery. The preparation of both biomaterials as polycrystalline solid pie[...]texto impreso
Feito Castellano, María José ; Serrano, M. C. ; Oñaderra Sánchez, Mercedes ; Matesanz Sancho, María Concepción ; Sánchez Salcedo, Sandra ; Arcos Navarrete, Daniel ; Vallet Regí, María ; Portolés Pérez, María Teresa | Royal Society of Chemistry | 2016-09-21Vascular endothelial growth factor (VEGF) plays an essential role in angiogenesis and vascular homeostasis. Endothelial progenitor cells (EPCs) are primitive bone marrow cells participating in neovascularization and revascularization processes, [...]texto impreso
Gómez-Cerezo, Natividad ; Casarrubios, L. ; Morales, I. ; Feito Castellano, María José ; Vallet Regí, María ; Arcos Navarrete, Daniel ; Portolés Pérez, María Teresa | Elsevier | 2018-10-15A mesoporous bioactive glass (MBG) of molar composition 75SiO2-20CaO-5P2O5 (MBG-75S) has been synthetized as a potential bioceramic for bone regeneration purposes. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), nitroge[...]texto impreso
Díez Orejas, Rosalía ; Casarrubios, Laura ; Feito Castellano, María José ; Rojo, J.M. ; Vallet Regí, María ; Arcos Navarrete, Daniel ; Portolés Pérez, María Teresa | Elsevier | 2021-02-15The use of nanoparticles for intracellular drug delivery could reduce the toxicity and side effects of the drug but, the uptake of these nanocarriers could induce adverse effects on cells and tissues after their incorporation. Macrophages play a[...]texto impreso
Linares, J. ; Fernández, A. B. ; Feito Castellano, María Jose? ; Matesanz Sancho, María Concepción ; Sánchez-Salcedo, Sandra ; Arcos Navarrete, Daniel ; Vallet Regí, María ; Rojo, J.M. ; Portolés Pérez, M. T. | Royal Society of Chemistry | 2016Silicon substituted and nanocrystalline hydroxyapatites have attracted the attention of many researchers due to their up-regulation in osteoblast cell metabolism and enhanced bioreactivity, respectively. On the other hand, the biomaterial succes[...]texto impreso
Doadrio Villarejo, Antonio Luis ; Izquierdo-Barba, Isabel ; Colilla Nieto, Montserrat ; Martínez Alonso, África ; Sánchez Salcedo, Sandra ; García Fontecha, Ana ; Cabañas Criado, Maria Victoria ; Peña López, Juan ; Román Zaragoza, Jesús ; Salinas Sánchez, Antonio J. ; Doadrio Villarejo, Juan Carlos ; Gutiérrez Ríos, María Teresa ; Arcos Navarrete, Daniel ; Moreno Pérez, José Manuel ; Vallet Regí, María ; Sánchez Montero, José María | 2017-06-07Se ha construido una base de datos con las propiedades de los elementos químicos, isótopos naturales y artificiales de los elementos y el tiempo de semivida de los radiactivos, así como, la serie de la tabla periódica a la que pertenecen, caráct[...]texto impreso
Cabañas Criado, Victoria ; Lozano Borregón, Daniel ; Torres-Pardo, A. ; Sobrino, C. ; González-Calvet, J. ; Arcos Navarrete, Daniel ; Vallet Regí, María | Elsevier | 2018-12-01Aminopropyl modified mesoporous SiO2 nanoparticles, MCM-41 type, have been synthesized by the co-condensation method from tetraethylorthosilicate (TEOS) and aminopropyltriethoxysilane (APTES). By means of modifying TEOS/APTES ratio we have carri[...]texto impreso
Maycas, Marta ; Portolés Pérez, María Teresa ; Matesanz Sancho, María Concepción ; Buendía, Irene ; Linares, Javier ; Feito Castellano, María José ; Arcos Navarrete, Daniel ; Vallet Regí, María ; Plotkin, Lilian I. ; Esbrit, Pedro ; Gortázar, Arancha R. | Wiley | 2017-12Diabetes mellitus (DM) induces bone deterioration, while mechanical stimulation promotes osteocyte-driven bone formation. We aimed to evaluate the interaction of acute exposure (24 h) to high glucose (HG) with both the pro-survival effect confer[...]texto impreso
Casarrubios, Laura ; Gómez-Cerezo, Natividad ; Feito Castellano, María José ; Vallet Regí, María ; Arcos Navarrete, Daniel ; Portolés Pérez, María Teresa | Elsevier | 2018-12-01Mesoporous nanospheres in the system SiO2-CaO (NanoMBGs) with a hollow core surrounded by a radial arrangement of mesopores were characterized, labeled with FITC (FITC-NanoMBGs) and loaded with ipriflavone (NanoMBG-IPs) in order to evaluate thei[...]texto impreso
Casarrubios, Laura ; Gomez Cerezo, Natividad ; Feito Castellano, María José ; Vallet Regí, María ; Arcos Navarrete, Daniel ; Portolés Pérez, María Teresa | MDPI | 2020-12-21The incorporation and effects of hollow mesoporous nanospheres in the systemSiO2–CaO (nanoMBGs) containing ipriflavone (IP), a synthetic isoflavone that prevents osteoporosis, were evaluated. Due to their superior porosity and capability to host[...]texto impreso
Guisasola, Eduardo ; Báez Rubio, Alejandro ; Talelli, Marina ; Arcos Navarrete, Daniel ; Moros, Maria ; Fuente, Jesus M. de la ; Vallet Regí, María | American Chemical Society | 2015-11-04Magnetically triggered drug delivery nanodevices have attracted great attention in nanomedicine, as they can feature as smart carriers releasing their payload at clinician's will. The key principle of these devices is based on the properties of [...]
