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Gómez, A. ; Gómez Sánchez, José ; López Torres, Mónica ; Naudi, Alba ; Mota Martorrell, N. ; Pamplona, R. ; Barja de Quiroga, Gustavo | Springer | 2015-06It has been described that dietary cysteine reverses many of the beneficial changes induced by methionine restriction in aging rodents. In this investigation male Wistar rats were subjected to diets low in methionine, supplemented with cysteine,[...]texto impreso
Mota Martorell, Natalia ; Jové, Mariona ; Pradas, Irene ; Berdún, Rebeca ; Sánchez, Isabel ; Naudi, Alba ; Gari, Eloi ; Barja de Quiroga, Gustavo ; Pamplona, Reinald | Springer | 2020-06Species longevity varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of longevity could converge in the mammalian targe[...]texto impreso
Jové, Mariona ; Mate Otaño, Ianire ; Naudi, Alba ; Mota Martorell, Natalia ; Portero Otín, Manuel ; Fuente del Rey, Mónica de la ; Pamplona, Reinald | The Gerontological Society of America | 2016A molecular description of the mechanisms by which aging is produced is still very limited. Here, we have determined the plasma metabolite profile by using high-throughput metabolome profiling technologies of 150 healthy humans ranging from 30 t[...]texto impreso
Galván, Ismael ; Naudi, Alba ; Erritzøe, Johannes ; Møller, Anders P. ; Barja de Quiroga, Gustavo ; Pamplona, Reinald | Wiley | 2015-10The evolution of lifespan is a central question in evolutionary biology, begging the question why there is so large variation among taxa. Specifically, a central quest is to unravel proximate causes of ageing. Here, we show that the degree of un[...]texto impreso
Mota-Martorell, Natalia ; Jové, Mariona ; Pradas, Irene ; Sánchez, Isabel ; Gómez, José ; Naudi, Alba ; Barja de Quiroga, Gustavo ; Pamplona, Reinald | Elsevier | 2020-04-20Mitochondrial reactive oxygen species (ROS) production, specifically at complex I (Cx I), has been widely suggested to be one of the determinants of species longevity. The present study follows a comparative approach to analyse complex I in hear[...]texto impreso
Martínez Cisuelo, V. ; Gómez, J. ; García Junceda, I. ; Naudi, Alba ; Cabré, R. ; Mota Martorell, N. ; López Torres, Mónica ; González Sánchez, Mónica ; Pamplona, R. ; Barja de Quiroga, Gustavo | Elsevier | 2016-10Rapamycin consistently increases longevity in mice although the mechanism of action of this drug is unknown. In the present investigation we studied the effect of rapamycin on mitochondrial oxidative stress at the same dose that is known to incr[...]
