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Gómez, A. ; Gómez Sánchez, José ; López Torres, Mónica ; Naudi, Alba ; Mota Martorrell, N. ; Pamplona, R. ; Barja de Quiroga, Gustavo | Springer | 2015-06It has been described that dietary cysteine reverses many of the beneficial changes induced by methionine restriction in aging rodents. In this investigation male Wistar rats were subjected to diets low in methionine, supplemented with cysteine,[...]texto impreso
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Mota Martorell, Natalia ; Jové, Mariona ; Pradas, Irene ; Berdún, Rebeca ; Sánchez, Isabel ; Naudi, Alba ; Gari, Eloi ; Barja de Quiroga, Gustavo ; Pamplona, Reinald | Springer | 2020-06Species longevity varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of longevity could converge in the mammalian targe[...]texto impreso
Galván, Ismael ; Naudi, Alba ; Erritzøe, Johannes ; Møller, Anders P. ; Barja de Quiroga, Gustavo ; Pamplona, Reinald | Wiley | 2015-10The evolution of lifespan is a central question in evolutionary biology, begging the question why there is so large variation among taxa. Specifically, a central quest is to unravel proximate causes of ageing. Here, we show that the degree of un[...]texto impreso
Mota-Martorell, Natalia ; Jové, Mariona ; Pradas, Irene ; Sánchez, Isabel ; Gómez, José ; Naudi, Alba ; Barja de Quiroga, Gustavo ; Pamplona, Reinald | Elsevier | 2020-04-20Mitochondrial reactive oxygen species (ROS) production, specifically at complex I (Cx I), has been widely suggested to be one of the determinants of species longevity. The present study follows a comparative approach to analyse complex I in hear[...]texto impreso
Costa Ruiz, Jorge de ; Barja de Quiroga, Gustavo ; Almaida-Pagan, Pedro F. | The Company of Biologists | 2020-06-04The lipid composition of cell membranes is linked to metabolic rate and lifespan in mammals and birds but very little information is available for fish. In this study, three fish species of the short-lived annual genus Nothobranchius with differ[...]texto impreso
Gredilla Diaz, Ricardo ; Sánchez-Román Rojas, Inés ; Gómez Rodríguez, Alexia ; López Torres, Mónica ; Barja de Quiroga, Gustavo | Springer | 2020-01-22Damage to DNA is especially important for aging. High DNA repair could contribute, in principle, to lower such damage in long-lived species. However, previous studies showed that repair of endogenous damage to nuclear DNA (base excision repair, [...]texto impreso
Martínez Cisuelo, V. ; Gómez, J. ; García Junceda, I. ; Naudi, Alba ; Cabré, R. ; Mota Martorell, N. ; López Torres, Mónica ; González Sánchez, Mónica ; Pamplona, R. ; Barja de Quiroga, Gustavo | Elsevier | 2016-10Rapamycin consistently increases longevity in mice although the mechanism of action of this drug is unknown. In the present investigation we studied the effect of rapamycin on mitochondrial oxidative stress at the same dose that is known to incr[...]texto impreso
A large amount of the longevity-modulating genes discovered during the last two decades are highly conserved during evolution from yeast and invertebrates to mammals. Many different kinds of evidence converge in the concept that life extending m[...]
