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El envejecimiento es un proceso fisiológico que se puede definir como la pérdida progresiva y general de las funciones del organismo con una menor capacidad de reaccionar de forma adaptativa a los cambios, produciéndose la pérdida de la homeocin[...]texto impreso
Vida, Carmen ; Martínez de Toda Cabeza, Irene ; Garrido Tarrio, Antonio ; Caro, Eva ; Molina, José Antonio ; Fuente del Rey, Mónica de la | Frontiers Media | 2018-01Since aging is considered the most risk factor for sporadic Alzheimer’s Disease (AD), the age-related impairment of the immune system (immunosenescence), based on a chronic oxidative-inflammatory stress situation, could play a key role in the de[...]texto impreso
Garrido Tarrio, Antonio ; Cruces, Julia ; Iriarte, Idoia ; Hernández Sánchez, Catalina ; Pablo, Flora de ; Fuente del Rey, Mónica de la | Elsevier | 2017-02Introducción: La salud depende del buen funcionamiento de los sistemas homeostáticos (el nervioso, endocrino e inmunitario) y de la adecuada comunicación entre ellos. Se ha comprobado que el estado funcional y redox del sistema inmunitario es un[...]texto impreso
Garrido Tarrio, Antonio ; Cruces, Julia ; Ceprián, Noemí ; Vara Ameigeiras, Elena ; Fuente del Rey, Mónica de la | MDPI | 2019-02-12Oxidative and inflammatory stresses are closely related processes, which contribute to age-associated impairments that affect the regulatory systems such as the immune system and its immunosenescence. Therefore, the aim of this work was to confi[...]texto impreso
Garrido Tarrio, Antonio ; Cruces, Julia ; Ceprián, N. ; Hernández-Sánchez, C. ; Fuente del Rey, Mónica de la | Elsevier | 2018Aging is accompanied by impairment in the nervous, immune, and endocrine systems as well as in neuroimmunoendocrine communication. In this context, there is an age-related alteration of the physiological response to acute stress, which is modula[...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; Garrido Tarrio, Antonio ; Fuente del Rey, Mónica de la | Oxford University Press | 2019-02-11Oxidative stress has been reported to increase with aging and although several agerelated changes in redox parameters have been described, none of them have been verified as markers of the rate of aging and lifespan. Therefore, antioxidant (cata[...]texto impreso
Vida, Carmen ; Martínez de Toda Cabeza, Irene ; Cruces, Julia ; Garrido Tarrio, Antonio ; González Sánchez, Mónica ; Fuente del Rey, Mónica de la | Elsevier | 2017The age-related changes in the immune functions (immunosenescence) may be mediated by an increase of oxidative stress and damage affecting leukocytes. Although the “oxidation-inflammation” theory of aging proposes that phagocytes are the main im[...]texto impreso
Garrido Tarrio, Antonio ; Cruces González, Julia ; Hernández Sánchez, C. ; Pablo, F. de ; Fuente del Rey, Mónica de la | Springer | 2020-08-09The social environment can influence the functional capacity of nervous and immune systems, and consequently the state of health, especially in aged individuals. Adult female tyrosine hydroxylase haploinsufficient (TH-HZ) mice exhibit behavioral[...]texto impreso
Garrido Tarrio, Antonio ; Cruces, Julia ; Ceprián, Noemí ; Corpas, Isabel ; Tresguerres, Jesús A. ; Fuente del Rey, Mónica de la | Springer | 2019-02Aging is associated with a chronic oxidative stress (increase of oxidants and decrease of antioxidants), which contributes to immunosenescence and therefore shorter longevity. Nevertheless, a positive social network has been related to the adequ[...]texto impreso
Garrido Tarrio, Antonio ; Cruces, Julia ; Ceprián, Noemí ; Díaz del Cerro, E. ; Félix, J. ; Fuente del Rey, Mónica de la | Elsevier | 2020-04-10Adult prematurely aging mice (PAM) show behavioral deterioration, premature immunosenescence and increased oxidative stress, impairments that are associated with their shorter lifespan, compared to the corresponding exceptional non-prematurely a[...]
