Información del autor
Documentos disponibles escritos por este autor (40)
Añadir el resultado a su cesta Hacer una sugerencia Refinar búsqueda
texto impreso
Redondo Useros, Noemí ; Gheorghe, Alina ; Pérez de Heredia, Fátima ; Díaz, Ligia Esperanza ; Baccan, Gyselle Chrystina ; Fuente del Rey, Mónica de la ; Marcosa, Ascensión | Elsevier | 2019-11-29Objective We aimed to assess whether 2-hydroxyoleic acid (2-OHOA) and n-3 polyunsaturated fatty acids (PUFA) could counteract changes on adipokine secretion and cardiometabolic risk biomarkers associated with high-fat diet-induced obesity in mic[...]texto impreso
Mela Rivas, Virginia ; Hernández, Oskarina ; Hunsche, Caroline ; Díaz, Francisca ; Chowen, Julie A. ; Fuente del Rey, Mónica de la | Elsevier | 2017-10-15The importance of the neonatal leptin surge in rodents in neurodevelopmental processes has aroused curiosity in its implication in other physiological systems. Given the role of leptin in neuro-immune interactions, we hypothesized that the neona[...]texto impreso
Martínez de Toda Cabeza, Irene ; Miguélez, Lara ; Vida, Carmen ; Carro, Eva ; Fuente del Rey, Mónica de la | IOS Press | 2019-09-03Oxidative stress plays an essential and early role in the pathophysiology of Alzheimer’s disease (AD). Alterations in the redox state in AD and in mild cognitive impairment (MCI) patients appear in the brain and at peripheral level. Given that i[...]texto impreso
The decrease in the proliferative response of lymphocytes is one of the most evident among the age-related changes of the immune system. This has been linked to a higher risk of mortality in both humans and experimental animals. However, long-li[...]texto impreso
Daza, Rafael ; González Bermúdez, Blanca ; Cruces, Julia ; Fuente del Rey, Mónica de la ; Plaza, Gustavo R. ; Arroyo Hernández, María ; Elices, Manuel ; Pérez Rigueiro, José ; Guinea, Gustavo V. | Elsevier | 2019-04-08A comparative analysis of T-lymphocyte mechanical data obtained from Micropipette Aspiration (MPA) andAtomic Force Microscopy (AFM) is presented. Results obtained byfitting the experimental data to simple Hertzand Theret models led to non-Gaussi[...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; Sanz San Miguel, Luis ; Fuente del Rey, Mónica de la | Hindawi | 2019-06-02According to the oxidative-inflammatory theory of aging, there is a link between the function, the oxidative-inflammatory stress state of immune cells, and longevity. However, it is unknown which immune cell parameters can predict lifespan and i[...]texto impreso
Martínez de Toda Cabeza, Irene ; Miguélez, Lara ; Siboni, León ; Vida, Carmen ; Fuente del Rey, Mónica de la | Springer | 2019-08-08Chronic stress situations lead to an impairment of immune response and higher oxidative and inflammatory stress, which are important underlying mechanisms of the ageing process. However, given that the physiological stress response depends on th[...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; Ortega, Eduardo ; Fuente del Rey, Mónica de la | Elsevier | 2016-11Under stressful conditions, the expression of the chaperone Hsp70 is induced, which acts as a cellular defense mechanism. The impairment in this induction has been related to aging, whereas an increased expression has been related to longevity. [...]texto impreso
Jové, Mariona ; Mate Otaño, Ianire ; Naudi, Alba ; Mota Martorell, Natalia ; Portero Otín, Manuel ; Fuente del Rey, Mónica de la ; Pamplona, Reinald | The Gerontological Society of America | 2016A molecular description of the mechanisms by which aging is produced is still very limited. Here, we have determined the plasma metabolite profile by using high-throughput metabolome profiling technologies of 150 healthy humans ranging from 30 t[...]texto impreso
Borras, Consuelo ; Abdelaziz, Kheira M. ; Gambini, Juan ; Serna, Eva ; Inglés, Marta ; Fuente del Rey, Mónica de la ; García, Idoia ; Matheu, Ander ; Sanchís, Paula ; Belenguer, Ángel ; Errigo, Alessandra ; Avellana, Juan Antonio ; Barettino, Ana ; Lloret Fernández, Carla ; Flames, Nuria ; Pes, Gianni ; Rodriguez Mañas, Leocadio ; Viña, José | Aging | 2016-10-28Centenarians not only enjoy an extraordinary aging, but also show a compression of morbidity. Using functional transcriptomic analysis of peripheral blood mononuclear cells (PMBC) we identified 1721 mRNAs differentially expressed by centenarians[...]texto impreso
Hunsche, Caroline ; Hernández, Oskarina ; Gheorghe, Alina ; Díaz, Ligia Esperanza ; Marcos, Ascensión ; Fuente del Rey, Mónica de la | Springer Link | 2017-02-23Purpose: Obesity is associated with impaired immune defences and chronic low levels of inflammation and oxidation. In addition, this condition may lead to premature aging. The aim of the study was to evaluate the effects of a nutritional supplem[...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; García-Salmones, Marta ; Alonso-Fernández, Patricia ; Fuente del Rey, Mónica de la | Oxford University Press | 2019-10-20Several parameters of immune function, oxidative, and inflammatory stresses have been proposed as markers of health and predictors of longevity and mortality. However, it is unknown if any of these parameters can be used as predictors of surviva[...]texto impreso
Martínez de Toda Cabeza, Irene ; Maté, Ianire ; Vida, Carmen ; Cruces, Julia ; Fuente del Rey, Mónica de la | Aging | 2016Chronological age is not a good indicator of how each individual ages and thus how to maintain good health. Due to the long lifespan in humans and the consequent difficulty of carrying out longitudinal studies, finding valid biomarkers of the bi[...]texto impreso
Hunsche, Caroline ; Martínez de Toda Cabeza, Irene ; Fuente del Rey, Mónica de la | Elsevier | 2019-05The aim of the present study was to investigate whether the late onset of diet-induced obesity (DIO) in middle-aged mice affected behavioral, immunological and oxidative stress parameters as well as life span of male and female mice. Also, it wa[...]texto impreso
Hunsche, Caroline ; Hernández, Oskarina ; Fuente del Rey, Mónica de la | The Gerontological Society of America | 2016Obesity and aging share an impaired immune system and oxidative and inflammatory stress. Therefore, the hypothesis of obesity as a possible model of premature immunosenescence has been proposed. In this study, we investigated whether adult obese[...]
