Información del autor
Autor Pintor, Jesús |
Documentos disponibles escritos por este autor (65)
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Awad Alkozi, Hanan ; Navarro, Gemma ; Aguinaga, David ; Reyes-Resina, Irene ; Sánchez Naves, Juan ; Pérez de Lara, María Jesús ; Franco, Rafael ; Pintor, Jesús | The British Pharmacological Society / Wiley-Blackwell | 2020-01-04Background and Purpose: Often, glaucoma courses with elevated eye hydrostatic pression, which is regulated by endogenous melatonin. Via ?1?adrenoceptor activation, phenylephrine increases cytoplasmic [Ca2+] that is detrimental in glaucoma. The a[...]texto impreso
Colligris, Basilio ; Crooke, Almudena ; Huete Toral, Fernando ; Pintor, Jesús | Taylor & Francis | 2014-07Introduction: Dry eye disease is a common disorder provoking changes in tear film and ocular surface. Untreated dry eye could cause ocular infections, corneal ulcer and blindness. Only a few drugs are authorized so far for the treatment of dry e[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Spanish General Council of Optometrists | 2017-11Purpose/aim: Glaucoma consists of a group of progressive optic neuropathies that are characterized by degeneration of the optic nerve and irreversible visual filed loss. Elevated intraocular pressure is the only proven treatable risk factor and [...]texto impreso
Carracedo Rodríguez, Juan Gonzalo ; Gonzalez-Meijome, Jose Manuel ; Pintor, Jesús | The Association for Research in Vision and Ophthalmology, Inc. | 2012-07Purpose.: To evaluate the levels of dinucleotides diadenosine tetraphosphate (Ap4A) and diadenosine pentaphosphate (Ap5A) in tears of patients wearing rigid gas permeable (RGP) contact lenses on a daily wear basis and of patients wearing reverse[...]texto impreso
Martínez Águila, Alejandro ; Fonseca Vázquez, Begoña ; Pérez de Lara, María Jesús ; Miras Portugal, María Teresa ; Gómez Villafuertes, María Rosa ; Carracedo Rodríguez, Juan Gonzalo ; Pintor, Jesús | 2020-07-29Purpose: The objective of this study was to evaluate the changes in the melatoninergic receptors of DBA/2J and C57BL/6J mice with the development of glaucoma. DBA/2J mice are widely used to study the physiopathology of glaucoma due to the simila[...]texto impreso
Fonseca Vázquez, Begoña ; Martínez Águila, Alejandro ; Pérez de Lara, María Jesús ; Miras Portugal, María Teresa ; Gómez Villafuertes, María Rosa ; Pintor, Jesús | Frontiers Media | 2017-10-10Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal mode[...]texto impreso
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Mediero Muñoz, Aránzazu ; Guzmán Aránguez, Ana Isabel ; Crooke, Almudena ; Peral Cerdá, Assumpta ; Pintor, Jesús | The Association for Research in Vision and Ophthalmology, Inc. | 2008-11Purpose. To investigate the role of ERK1/2 and RhoA/ROCK intracellular pathways in the modification of corneal re-epithelialization when stimulated by the diadenosine polyphosphates Ap4A and Ap3A. Methods. In wounded confluent SIRC (Statens Seru[...]texto impreso
Carracedo Rodríguez, Juan Gonzalo ; Cacho, Isabel ; Sánchez Naves, Juan ; Pintor, Jesús | John Wiley & Sons Ltd. | 2014-02Purpose:? To study the concentrations of diadenosine polyphosphates in the ocular surface after PRK and LASIK. Methods:? Sixty-one patients (30 males and 31 females) with ages ranging from 20 to 63 (34.04 ± 9.13 years) were recruited in Balear I[...]texto impreso
Carracedo Rodríguez, Juan Gonzalo ; Peral Cerdá, Assumpta ; Pintor, Jesús | The Association for Research in Vision and Ophthalmology, Inc. | 2010-11Purpose.: To analyze the levels of diadenosine tetraphosphate (Ap4A) and diadenosine pentaphosphate (Ap5A) in tears of subjects with Sjögren syndrome and to compare them with those in a control group. Methods.: Twelve subjects with a diagnosis o[...]texto impreso
Peral Cerdá, Assumpta ; Carracedo Rodríguez, Juan Gonzalo ; Pintor, Jesús | Wiley-Blackwell | 2015-08Purpose To quantify diadenosine polyphosphate levels in tears of congenital aniridia patients to estimate the ocular surface changes associated with congenital aniridia compared to normal individuals. Methods Fifteen patients diagnosed with cong[...]texto impreso
Fonseca, Begoña ; Martínez Águila, Alejandro ; Pérez de Lara, María Jesús ; Pintor, Jesús | Springer | 2016-11Glaucoma is a neurodegenerative disease that produces blindness. The main factor associated with this disease is an abnormally elevated intraocular pressure (IOP). To date, some attempts have been made to demonstrate the role of nucleotides modu[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Elsevier | 2015-05The effect of the dinucleotide P1, P4-Di (adenosine-5') tetraphosphate (Ap4A) in improving adrenergic anti-glaucomatous delivery by modifying the tight junction proteins of the corneal epithelium was evaluated. Stratified human corneal epithelia[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | The British Pharmacological Society / Wiley-Blackwell | 2015-02BACKGROUND AND PURPOSE: Here, we have studied the effects of the dinucleotide P1, P4-Di (adenosine-5?) tetraphosphate (Ap4A) on corneal barrier function conferred by the tight junction (TJ) proteins and its possible involvement in ocular drug de[...]texto impreso
García Porta, Nery ; Rico del Viejo, Laura ; Martín Gil, Alba ; Carracedo Rodríguez, Juan Gonzalo ; Pintor, Jesús ; Gonzalez-Meijome, Jose Manuel | Hindawi Publishing Corporation | 2016-08Purpose. To compare the ocular surface symptoms and signs in an adult population of silicone-hydrogel (Si-Hy) contact lens (CL) wearers with another modality of CL wear, overnight orthokeratology (OK). Materials and Methods. This was a prospecti[...]texto impreso
Dominguez Godínez, Carmen Olalla ; Carracedo Rodríguez, Juan Gonzalo ; Pintor, Jesús | Mary Ann Liebert | 2018-03-01Purpose: The aim of this study was to evaluate the ability to uptake and to deliver diquafosol from commercial contact lenses (CLs) and its effect on tear secretion. Methods: For both in vitro and in vivo experiments, two commercial silicone hyd[...]texto impreso
Guzmán Aránguez, Ana Isabel ; Fonseca, Begoña ; Carracedo Rodríguez, Juan Gonzalo ; Martín Gil, Alba ; Martínez Águila, Alejandro ; Pintor, Jesús | Contact Lens Association of Ophthalmologists | 2016-09Dry eye disease affects a substantial segment of the word population with increasing frequency. It is a multifactorial disease of the ocular surface and tear film, which causes ocular discomfort, visual disturbances, and tear instability with po[...]texto impreso
Mediero Muñoz, Aránzazu ; Peral Cerdá, Assumpta ; Pintor, Jesús | The Association for Research in Vision and Ophthalmology, Inc. | 2006-10Purpose. To investigate the influence of diadenosine polyphosphates on the rate of corneal epithelial cell migration. Methods. Primary corneal epithelial cell cultures were obtained from New Zealand White rabbits. Immunocytochemical experiments [...]texto impreso
Crooke, Almudena ; Guzmán Aránguez, Ana Isabel ; Mediero Muñoz, Aránzazu ; Alarma-Estrany, Pilar ; Carracedo Rodríguez, Juan Gonzalo ; Pelaez, Teresa ; Peral Cerdá, Assumpta ; Pintor, Jesús | Taylor & Francis | 2015-01Purpose: We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. Methods: New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the c[...]texto impreso
Navarro Gil, Francisco Javier ; Huete Toral, Fernando ; Crooke, Almudena ; Dominguez Godínez, Carmen Olalla ; Carracedo Rodríguez, Juan Gonzalo ; Pintor, Jesús | American Society for Pharmacology and Experimental Therapeutics | 2019-10Melatonin has been shown to enhance tear secretion associated with dinucleotide diadenosine tetraphosphate. This study investigated the isolated action of melatonin and its analogs, agomelatine, N-butanoyl-2-(2-methoxy-6H-isoindolo[2,1-a]indol-1[...]texto impreso
Carracedo Rodríguez, Juan Gonzalo ; Martínez Águila, Alejandro ; Rodríguez Pomar, Candela ; Bodas Romero, Julia ; Sánchez Naves, Juan ; Pintor, Jesús | Springer Verlag | 2019-10-24Purpose: To evaluate the effect of a new nutritional supplement based on melatonin on the intraocular pressure (IOP) in normotensive subjects. Patients and methods: A short-term prospective study was designed. Sixty-seven normotensive subjects w[...]texto impreso
Carracedo Rodríguez, Juan Gonzalo ; Martín Gil, Ana ; Fonseca, Begoña ; Pintor, Jesús | Elsevier | 2016-08Objective: To evaluate the differences between goblet cell density (GCD) and symptomatology after one month of orthokeratology lens wear. Methods: A pilot, short-term study was conducted. Twenty-two subjects (29.7. ±. 7.0 years old) participated[...]texto impreso
Alkozi, Hanan Awad ; Sánchez Naves, Juan ; Pérez de Lara, María Jesús ; Carracedo Rodríguez, Juan Gonzalo ; Fonseca, Begoña ; Martínez Águila, Alejandro ; Pintor, Jesús | John Wiley & Sons Ltd. | 2016-09-06Purpose: To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma. Methods : A total of 37 eyes of 37 patients who underwent ca[...]texto impreso
Sight for mammals is one of the most appreciated senses. In humans there are several factors that contribute to the increment in all kind of eye diseases. This mini-review will focus on some diseases whose prevalence is steadily increasing year [...]texto impreso
Reyes Resina, Irene ; Alkozi, Hanan Awad ; Ser-Badia, Anna, del ; Sánchez Naves, Juan ; Lillo, Jaume ; Jiménez Cano, Jasmina ; Pintor, Jesús ; Navarro Brugal, Gemma ; Franco Fernández, Rafael | MDPI | 2020-01-08Background: Experiments in the late nineties showed an inverse relationship in the eye levels of melatonin and dopamine, thereby constituting an example of eye parameters that are prone to circadian variations. The underlying mechanisms are not [...]texto impreso
Pintor, Jesús ; Sánchez Nogueiro, Jesús ; Irazu, Marta ; Mediero Muñoz, Aránzazu ; Pelaez, Teresa ; Peral Cerdá, Assumpta | Springer | 2004Nucleotides present an important role in ocular physiology which has been demonstrated by recent works that indicate their involvement in many ocular processes. P2Y are important among P2 receptors since they can control tear production, corneal[...]texto impreso
Melatonin is a neurohormone synthesized in the pineal gland as well as in other organs and it plays an important role in many ocular functions, as it is synthesized in numerous eye structures. Melatonin can reduce the intraocular pressure and to[...]texto impreso
Dominguez Godínez, Carmen Olalla ; Martin-Gil, Alba ; Carracedo Rodríguez, Juan Gonzalo ; Guzmán Aranguez, Ana María ; Gonzalez-Meijome, Jose Manuel ; Pintor, Jesús | Spanish General Council of Optometrists | 2013-10Purpose To evaluate the possible use of soft contact lenses (CL) to improve the secretagogue role of diadenosine tetraphosphate (Ap4A) promoting tear secretion. Methods Two conventional hydrogel CL (Omafilcon A and Ocufilcon D) and two silico[...]texto impreso
Guzmán Aránguez, Ana Isabel ; Calvo del Bosque, Patricia ; Ropero Berzal, Inés ; Pintor, Jesús | Mary Ann Liebert | 2014-11-06Purpose: Treatment with topical eye drops for long-standing ocular diseases like allergy can induce detrimental side effects. The purpose of this study was to investigate in vitro cytotoxicity of commercially preserved and unpreserved anti-aller[...]texto impreso
Pérez de Lara, María Jesús ; Guzmán Aránguez, Ana Isabel ; Gómez Villafuertes, María Rosa ; Gualix, Javier ; Miras Portugal, María Teresa ; Pintor, Jesús | Springer | 2018-06-08The pathogenesis of glaucoma involves numerous intracellular mechanisms including the purinergic system contribution. Furthermore, the presence and release of nucleotides and dinucleotides during the glaucomatous damage and the maintenance of de[...]texto impreso
Peral Cerdá, Assumpta ; Carracedo Rodríguez, Juan Gonzalo ; Acosta Boj, Mª Carmen ; Gallar Martínez, Juana ; Pintor, Jesús | The Association for Research in Vision and Ophthalmology, Inc. | 2006-09Purpose. To analyze the levels of the diadenosine polyphosphates Ap4A and Ap5A in tears, in a set of control subjects and in groups of symptomatic and nonsymptomatic persons with dry eye. Methods. Ninety-seven subjects participated in the study.[...]texto impreso
Pérez de Lara, María Jesús ; Guzmán Aránguez, Ana Isabel ; Villa, Pedro, de la ; Díaz Hernández, Juan Ignacio ; Miras Portugal, María Teresa ; Pintor, Jesús | 2015-09-06Purpose: To study retinal extracellular ATP levels and to assess the changes in the vesicular nucleotide transporter (VNUT) expression in a murine model of glaucoma during the development of the disease. Methods: Retinas were obtained from glauc[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Taylor & Francis | 2016-09Purpose: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears. Methods: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples[...]texto impreso
Crooke, Almudena ; Martínez Henández, Juan ; Martínez López, Joaquín ; Cruz Jentoft, Alfonso ; Huete Toral, Fernando ; Pintor, Jesús | Biomed Central Ltd | 2017-05-19Ageing involves a progressive decline of the body’s regulatory systems including immune system. Adenosine regulates immune function by interaction with its receptors, mainly adenosine A2A receptor, present on the surface of immune cells. Further[...]texto impreso
Melatonin is not only synthesized by the pineal gland but by several ocular structures. This natural indoleamine is of great importance for regulating several eye processes, among which pressure homeostasis is included. Glaucoma, the most preval[...]texto impreso
Pelaez, Teresa ; Mediero Muñoz, Aránzazu ; Alarma-Estrany, Pilar ; Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Crooke, Almudena ; Kolligris, Basilio ; Peral Cerdá, Assumpta ; Pintor, Jesús | Real Academia Nacional de Farmacia | 2007The research on the effect of melatonin on intraocular pressure (IOP) is reviewed from the hystorical point of view of our laboratory. The original idea of melatonin modulating intraocular pressure has been improved by using selective compounds[...]texto impreso
Huete Toral, Fernando ; Crooke, Almudena ; Martínez Águila, Alejandro ; Pintor, Jesús | Mary Ann Liebert | 2015-01-01Melatonin and its analog 5-MCA-NAT (5-methylcarboxyamino-N-acetyl tryptamine) are active compounds reducing intraocular pressure (IOP). This action is mediated through MT2 and the putative MT3 melatonin receptor, producing a transient reduction [...]texto impreso
The articular cartilage present in joints is permanently subjected to physical stress, thus producing injuries and consequently pain. Chondrocytes are responsible for repairing this damage, but often the reparation tissue is inadequate. The appl[...]texto impreso
Melatonin is a substance synthesized in the pineal gland as well as in other organs. This substance is involved in many ocular functions, giving its synthesis in numerous eye structures. Melatonin is synthesized from serotonin through two enzyme[...]texto impreso
Colligris, Pade ; Pérez de Lara, María Jesús ; Colligris, Basilio ; Pintor, Jesús | Hindawi | 2018-07-30Dementia, including Alzheimer’s disease (AD), is a major disorder, leading to several ocular manifestations amongst the elderly population. These visual disorders may be due to retinal nerve degenerative changes, including nerve fibre layer thin[...]texto impreso
Carracedo Rodríguez, Juan Gonzalo ; Wang, Zicheng ; Serramito Blanco, María ; Martín Gil, Alba ; Carballo Álvarez, Jesús ; Pintor, Jesús | Contact Lens Association of Ophthalmologists, Inc. | 2016-05Objective: To evaluate the ocular surface temperature using an infrared thermography camera before and after wearing scleral lens in patients with keratoconus and correlate these results with the tear production and stability. Methods: A pilot, [...]texto impreso
Carpena Torres, Carlos ; Pintor, Jesús ; Pérez de Lara, María Jesús ; Huete Toral, Fernando ; Crooke, Almudena ; Pastrana, Cristina ; Carracedo Rodríguez, Juan Gonzalo | Hindawi Publishing Corporation | 2020-05-30Purpose. To optimize a rabbit dry eye model induced by topical instillation of benzalkonium chloride (BAC), reduce the days of instillation of the original model by increasing the concentration of BAC from 0.1% to 0.2%. Materials and Methods. [...]texto impreso
Carpena Torres, Carlos ; Pintor, Jesús ; Pérez de Lara, María Jesús ; Toral, Fernando ; Crooke, Almudena ; Pastrana, Cristina ; Carracedo Rodríguez, Juan Gonzalo ; Cayuela López, Ana ; Sorzano Sánchez, Óscar ; Charbel, Carla ; Garzón Jiménez, Nuria ; Carballo Álvarez, Jesús ; Diz Arias, Elena ; Fernández Jiménez, Elena ; Peral Cerdá, Assumpta ; Gómez Pedrero, José Antonio ; Durán Prieto, Elena ; López Alonso, José Manuel ; Fernández Torres, Miguel Ángel ; Guzmán Aránguez, Ana Isabel ; Gómez Manzanares, Ángela ; Vázquez Moliní, Daniel ; Martínez Antón, Juan Carlos ; Bernárdez Vilaboa, Ricardo ; Mayorga Pinilla, Santiago ; Álvarez Fernández-Balbuena, Antonio ; Benítez, AntoJ. ; El Youssfi, Asmae Igalla ; León Álvarez, Alejandro ; Palomo Álvarez, Catalina ; LLedó Mayans, Victoria Eugenia ; Awad Alkozi, Hanan ; Sánchez Naves, Juan ; Martínez Alberquilla, Irene ; García Montero, María ; Ruiz Alcocer, Javier ; Madrid Costa, David ; Martínez Florentín, Gema ; Papas, Eric B. ; Medrano Muñoz, Sandra Milena ; Molina, Nancy ; Jurado, Sandra ; Oliveiros López, Juan ; Platero Alvarado, Nadiuska Cristine ; Garrido Mercado, Rafaela ; Pérez Garmendia, Carlos ; Antona Peñalba, Beatriz ; Barrio de Santos, Ana Rosa ; González Pérez, Mariano ; Pérez Garmendia, Carlos ; Serramito Blanco, María ; Privado Aroco, Ana ; Almalki, Wael ; Bodas Romero, Julia ; Ouzzani, Mohamed ; Paune, Jaume ; Calderón García, Raquel ; Pitarch Velasco, Aida ; Cebrián, José Luis ; Sánchez Pérez, Isabel ; García Rojo, Marta María ; Bonnin Arias, Cristina ; Sánchez Ramos, Celia ; Gutiérrez Jorrín, Sara Carmen ; Rodríguez Alonso, Xabier ; Laucirica Sáenz, Gorka ; Arranz Márquez, Esther ; Alonso Castellanos, Miriam ; Teus Guezala, Miguel Ángel ; Hernández Verdejo, José Luis ; Mármol Errasti, Esther ; Martín García, Beatriz ; Arriola Villalobos, Pedro ; Gómez de Liaño, Rosario ; Mínguez Caro, N ; Orduña Azcona, Javier ; Navarro Gil, Francisco Javier ; Huete Toral, Fernando ; Rodríguez Pomar, Candela ; Pastrana Robles, Cristina ; Martínez Águila, Alejandro ; Martín Gil, Alba ; Tomé de la Torre, Miguel Ángel | Facultad de Óptica y Optometría (UCM) | 2020Por cuarto año consecutivo los doctorandos de la Facultad de Óptica y Optometría de la Universidad Complutense de Madrid cuentan con un congreso propio organizado por y para ellos, el 4º PhDAY- FOO. Se trata de un congreso gratuito abierto en [...]texto impreso
Carracedo Rodríguez, Juan Gonzalo ; Serramito Blanco, María ; Martín Gil, Alba ; Wang, Zicheng ; Rodríguez Pomar, Candela ; Pintor, Jesús | Wiley | 2017-11Background: The aim was to evaluate the turbidity and thickness of the post-lens tear layer and its effect on visual quality in patients with keratoconus after the beginning of lens wear and before lens removal at the end of eight hours. Methods[...]texto impreso
Pérez de Lara, María Jesús ; Avilés Trigueros, Marcelino ; Guzmán Aránguez, Ana Isabel ; Valiente Soriano, Francisco Javier ; Villa Polo, Pedro de la ; Vidal Sanz, Manuel ; Pintor, Jesús | Elsevier | 2019-05-16Glaucoma is a common cause of visual impairment and blindness, characterized by retinal ganglion cell (RGC) death. The mechanisms that trigger the development of glaucoma remain unknown and have gained significant relevance in the study of this [...]texto impreso
Carpena Torres, Carlos ; Pintor, Jesús ; Huete Toral, Fernando ; Rodríguez Pomar, Candela ; Martínez Águila, Alejandro ; Carracedo Rodríguez, Juan Gonzalo | Taylor & Francis | 2020-07-07Purpose: To evaluate the preclinical efficacy of eye drops based on an extract of Artemia salina on the ocular surface of rabbits. Tear secretion, tear break-up time and corneal staining were measured. Material and methods: A preclinical and sho[...]texto impreso
The aim of this study was to assess the changes of extracellular ATP levels during the progress of Alzheimer's disease by using a murine model of the disease. Retinal nucleotide release was measured from flattened whole-mounts stimulated with 59[...]texto impreso
Melanopsin is a non-image forming photoreceptor known to be present in the retina and it is considered to have light regulated tasks among other functions. In the present work, melanopsin presence in human lens epithelial cells as well as in hum[...]texto impreso
Carracedo Rodríguez, Juan Gonzalo ; Carpena, Carlos ; Concepción, Pablo ; Díaz, Victor ; García-García, Miguel ; Jemnic, Nahla ; Lledó, Victoria Eugenia ; Martín, Marina ; Pastrana, Cristina ; Pelissier, Raquel ; Veselinova, Albena ; Wang, Xiaoyu ; Pintor, Jesús | Spanish General Council of Optometrists | 2016-04-13