| Título: | Response to tocilizumab treatment in Graves’ ophthalmopathy by measuring rectus muscle thickness and chemosis using optical coherence tomography |
| Autores: | Gómez de Liaño, L. de Pablo ; Fernández Vigo, José Ignacio ; Troyano Rivas, J. ; Niño Rueda, Cristina ; Romo López, A. ; Gómez de Liaño, Rosario |
| Tipo de documento: | texto impreso |
| Editorial: | Elsevier - Sociedad Española de Oftalmología, 2018-06-22 |
| Dimensiones: | application/pdf |
| Nota general: | info:eu-repo/semantics/restrictedAccess |
| Idiomas: | |
| Palabras clave: | Estado = Publicado , Materia = Ciencias Biomédicas: Medicina: Diagnóstico por imagen y medicina nuclear , Materia = Ciencias Biomédicas: Medicina: Oftalmología , Materia = Ciencias Biomédicas: Óptica y optometría: Anatomía ocular , Tipo = Artículo |
| Resumen: |
Purpose: To assess the extraocular muscle thickness and chemosis after treatment with tocilizumab in patients with active Graves’ ophthalmopathy by optical coherence tomography. Methods: Case series of five patients with active Graves’ ophthalmopathy (clinical activity score ?4/10) treated with 4 doses of tocilizumab. These patients had been previously treated with corticosteroids with no response. Spectral-domain optical coherence tomography was employed to determine lateral and medial rectus muscle thickness and chemosis before and after 4 doses of tocilizumab given monthly. Scanning was performed at 3 and 9 o’clock (nasal and temporal). Results: The study included four women and one man with a median age of 52 years (range: 38-73). Median Graves’ ophthalmopathy activity duration was 17 months (12-18). Median medial rectus and determine lateral thicknesses pre-treatment were 249 ?m (174-366) and 337 ?m (142-443), respectively. Median chemosis was 409 ?m (290-610). After tocilizumab treatment, median muscle thicknesses reduced to 157 ?m (88-187) and 197 ?m (99-290), respectively (P = .043; Wilcoxon) and chemosis to 59 ?m (0-78). Median clinical activity score decreased from 5 (4-8) to 1 (0-3). Conclusions: A reduction in extraocular muscle thickness and chemosis was observed after treatment with tocilizumab in Graves’ ophthalmopathy patients using an optical coherence tomography, so this technique could be a useful complementary technique to assess the therapeutic responses. |
| En línea: | https://eprints.ucm.es/49439/1/Ni%C3%B1o%20Rueda%20-1-s2.0-S2173579418301075-main.pdf |
Ejemplares
| Estado |
|---|
| ningún ejemplar |
