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Título:
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Changes in Retinal OCT and Their Correlations with Neurological Disability in Early ALS Patients, a Follow-Up Study
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Autores:
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Rojas Lozano, Pilar ;
Hoz Montañana, María Rosa de ;
Ramírez Sebastián, Ana Isabel ;
Ferreras, Antonio ;
García Martín, Elena Salobrar ;
Muñóz Blanco, José L ;
Urcelay Segura, José Luis ;
Salazar Corral, Juan José ;
Ramirez Sebastian, Jose Manuel
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Tipo de documento:
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texto impreso
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Editorial:
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MDPI AG, 2019-12
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Dimensiones:
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application/pdf
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Nota general:
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cc_by
info:eu-repo/semantics/openAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Medicina: Neurociencias
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Materia = Ciencias Biomédicas: Óptica y optometría: Anatomía ocular
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Materia = Ciencias Biomédicas: Óptica y optometría: Técnicas de la imagen
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Tipo = Artículo
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Resumen:
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Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disability. Methods: All patients underwent a comprehensive neurological and ophthalmological examination. A linear mixed analysis and Bonferroni p-value correction were performed, testing four comparisons as follows: Control baseline vs. control follow-up, control baseline vs. ALS baseline, control follow-up vs. ALS follow-up, and ALS baseline vs. ALS follow-up. Results: The mean time from the diagnosis was 10.80 ± 5.5 months. The analysis of the optical coherence tomography (OCT) showed: (1) In ALS baseline vs. control baseline, a macular significantly increased thickness of the inner macular ring temporal and inferior areas; (2) in ALS follow-up vs. ALS baseline, a significant macular thinning in the inner and outer macular ring inferior areas; (3) in ALS follow-up vs. ALS baseline, a significant peripapillary retinal nerve fiber layer (pRNFL) thinning in the superior and inferior quadrants; and (4) ALS patients showed a moderate correlation between some OCT pRNFL parameters and Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) score. Conclusion: The OCT showed retinal changes in patients with motoneuron disease and could serve as a complementary tool for studying ALS.
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En línea:
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https://eprints.ucm.es/58011/1/Salazar%20_brainsci-09-00337.pdf
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