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The article is about the future therapeutic products based on advanced therapies such as gene and cell therapy and tissue engineering or induced pluripotent stem cell technology may offer innumerable potential clinical applicationsfor the treatm[...]texto impreso
Monogenic diseases are ideal candidates for treatment by the emerging advanced therapies, which are capable of correcting alterations in protein expression that result from genetic mutation. In hemophilia A and B such alterations affect the acti[...]texto impreso
In hemophilia, advanced therapies are warranted from a conceptual and methodological standpoint. Current advanced therapy strategies are centered on the use of adeno-associated viral vectors, although problems related to immunogenicity and hepat[...]texto impreso
Current treatment of joint cartilage lesions is based either on conventional techniques (bone marrow stimulation, osteochondral autograft or allograft transplantation) or on newly developed techniques (chondrocyte implantation and those based on[...]texto impreso
Haemophilia is a hereditary X-linked recessive disorder caused by a deficiency of either clotting factor VIII (haemophilia A) or IX (haemophilia B). Conventional treatment is currently based on the use of either plasma derived or recombinant coa[...]texto impreso
There is much to be investigated about the specific characteristics of stem cells and about the efficacy and safety of the new drugs based on this type of cells, both embryonic as adult stem cells, for several therapeutic indications (cardiovasc[...]texto impreso
La obra se estructura en cuatro partes. En la primera se dan conceptos generales sobre qué es la sangre y su función en el organismo. En la segunda parte aborda la enfermedad de la hemofilia, sus causas, tipos, síntomas clínicos y su transmisión[...]texto impreso
Human induced pluripotent stem cells (iPSCs) have revolutionized the stem cell field. These iPSCs from somatic cells have been reprogrammed with the introduction of transcription factors and are capable to differentiate into cells from all three[...]texto impreso
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Olmedillas López, Susana ; García Arranz, Mariano ; García Olmo, Damián ; Liras, Antonio | PeerJ Computer Science | 2016-04-14Background. Hemophilia is a rare recessive X-linked disease characterized by a deficiency of coagulation factor VIII or factor IX. Its current treatment is merely palliative. Advanced therapies are likely to become the treatment of choice for th[...]texto impreso
Serrano, Luis J. ; Cañete, Ana ; García Leal, Tamara ; Tomás Gallardo, Laura ; Flores, Ana I. ; Torre, Paz de la ; Liras, Antonio ; Sánchez, María José | Thieme Publishing | 2018-08The development of new strategies based on cell therapy approaches to correct haemophilia A (HA) requires further insights into new cell populations capable of producing coagulation factor VIII (FVIII) and presenting stable engraftment potential[...]texto impreso
With the eradication of infection by HIV and hepatitis C virus that were common just a few years ago, the most concerning adverse effect resulting from the use of both recombinant and plasma-derived products is the appearance of antibodies (inhi[...]
