| Título: | Design and characterization of an ocular topical liposomal preparation to replenish the lipids of the tear film |
| Autores: | Vicario de la Torre, Marta ; Benítez del Castillo, José Manuel ; Vico Ruiz, Eva ; Guzmán, Manuel ; Heras Polo, Beatriz de las ; Herrero Vanrell, Rocío ; Molina Martínez, Irene Teresa |
| Tipo de documento: | texto impreso |
| Editorial: | Association for Research in Vision and Ophthalmology (ARVO), 2014-12 |
| Dimensiones: | application/pdf |
| Nota general: | info:eu-repo/semantics/openAccess |
| Idiomas: | |
| Palabras clave: | Estado = Publicado , Materia = Ciencias Biomédicas: Farmacia , Materia = Ciencias Biomédicas: Farmacia: Farmacología , Materia = Ciencias Biomédicas: Farmacia: Tecnología farmaceútica , Tipo = Artículo |
| Resumen: |
Purpose: Dry eye (DE) includes a group of diseases related to tear film disorders. Current trends for DE therapy focus on providing lipid components to replace the damaged lipid layer. Formulations that contain aqueous and mucin like compounds may have additional therapeutic benefits for DE patients. The aim of this work was to design and evaluate novel formulations having the potential to become topical treatment for DE. Methods: Unpreserved liposomal formulations composed of phosphatidylcholine (PC), cholesterol, and ? tocopherol (vit E) were prepared by the thin-film hydration technique. Formulations were characterized in terms of liposome size, pH, surface tension, osmolarity, and viscosity. In vitro tolerance assays were performed on macrophage, human corneal and conjunctival cell lines at short and long term exposures. In vivo ocular tolerance was studied after instillation of the formulation. Results: The mean liposome size was less than 1 ?m and surface tension Conclusions: The unpreserved liposomal formulation has suitable properties to be administered by topical ophthalmic route. The liposome-based artificial tear had good in vitro and in vivo tolerance responses. This formulation composed of a combination of liposomes and bioadhesive polymers may be employed successfully as a tear film substitute in DE therapy. |
| En línea: | https://eprints.ucm.es/51774/1/Vicario-Design%20and%20Characterizationi1552-5783-55-12-7839.pdf |
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