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Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Cadena Santoyo, Manuel ; Elvira Hurtado, Lorena ; Salazar Corral, Juan José ; Hoz Montañana, Rosa de ; Ramirez Sebastian, Jose Manuel | Frontiers Media | 2020-09-25Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes degeneration of the lower and upper motor neurons and is the most prevalent motor neuron disease. This disease is characterized by muscle weakness, stiffness, and hyp[...]texto impreso
García Martín, Elena Salobrar ; Hoyas, Irene ; Leal, Mercedes ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Yubero Pancorbo, Raquel ; Gil, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Hindawi Publising Corp. | 2015-06-08Decreased thickness of the retinal nerve fiber layer (RNFL) may reflect retinal neuronal-ganglion cell death. A decrease in the RNFL has been demonstrated in Alzheimer’s disease (AD) in addition to aging by optical coherence tomography (OCT). Tw[...]texto impreso
Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa, de ; García Martín, Elena Salobrar ; Rojas, Pilar ; Fernández Arrabal, José A. ; López Cuenca, Inés ; Rojas López, Blanca ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | IntechOpen | 2018-11The optic nerve (ON) is constituted by the axons of the retinal ganglion cells (RGCs). These axons are distributed in an organized pattern from the soma of the RGC to the lateral geniculated nucleus (where most of the neurons synapse). The key p[...]texto impreso
Gracia Pacheco, Pablo de ; Gallego Collado, Beatriz Isabel ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Salazar Corral, Juan José ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Public Library of Science | 2015-11-18Proliferation of microglial cells has been considered a sign of glial activation and a hallmark of ongoing neurodegenerative diseases. Microglia activation is analyzed in animal models of different eye diseases. Numerous retinal samples are requ[...]texto impreso
Fernández Albarral, José Antonio ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Pinazo Durán, Mª Dolores ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | Medknow Publications | 2020-01-28Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressa[...]texto impreso
Rojas Lozano, Pilar ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; Ferreras, Antonio ; García Martín, Elena Salobrar ; Muñóz Blanco, José L ; Urcelay Segura, José Luis ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI AG | 2019-12Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disabi[...]texto impreso
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Bravo Alcobendas, Noelia ; Zulueta, Joseba ; García Martín, Elena Salobrar ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | International Journal of Medical Students | 2015-09The purpose of this paper is to conduct a review of studies on cystoid macular edema published in the last seven years. Cystoid macular edema is a major cause of loss of visual acuity. It is the final common pathway of many diseases and can be c[...]texto impreso
Ramos Cordero, Primitivo ; Serrano Garijo, Pilar ; Tena-Dávila Mata, Mª Cruz ; Nieto López-Guerrero, Jerónimo ; Romero Chaparro, Rosario ; García Carpio, María del Sol ; Rojos Mateo, Begoña ; Ramirez Sebastian, Jose Manuel ; Triviño Casado, Alberto ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, Blanca ; García Merino, José Ignacio ; Jover Ibarra, José ; Aguirre Martín-Gil, Ramón ; Pinto Fontanillo, José Antonio | Consejería de Sanidad - D. G. de Salud Pública | 2007Este documento, que constituye el nº 8 de la colección Promoción de la salud en las personas mayores, pretende abordar buena parte de los problemas de salud de este colectivo aportando criterios y metodología para la intervención a sus cuidadore[...]texto impreso
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A través de los años, los científicos han indagado sobre el concepto de que "los ojos son el espejo del alma”, en busca de evidencias científicas que determinen si la investigación ocular podría ser útil para la investigación del cerebro y el [...]texto impreso
García Antón, María Teresa ; Salazar Corral, Juan José ; Hoz Montañana, Rosa de ; Rojas López, Blanca ; Ramírez Sebastián, Ana Isabel ; Triviño Casado, Alberto ; Aroca Aguilar, José Daniel ; García Feijoo, Julián ; Escribano, Julio ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2017-04-27Mutations in the CYP1B1 gene are currently the main known genetic cause of primary congenital glaucoma (PCG), a leading cause of blindness in children. Here, we analyze for the first time the CYP1B1 genotype activity and the microscopic and clin[...]texto impreso
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Gallego Collado, Beatriz Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salinas Navarro, Manuel Ángel ; Ortín Martínez, Arturo ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Biomed Central Ltd | 2012-05-12Background Ocular hypertension is a major risk factor for glaucoma, a neurodegenerative disease characterized by an irreversible decrease in ganglion cells and their axons. Macroglial and microglial cells appear to play an important role in the [...]texto impreso
Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Gallego Collado, Beatriz Isabel ; García Martín, Elena Salobrar ; Valiente Soriano, Francisco Javier ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Elsevier | 2015Most studies employing experimental models of unilateral glaucoma have used the normotensive contralateral eye as the normal control. However, some studies have recently reported the activation of the retinal macroglia and microglia in the uninj[...]
