Información del autor
Autor Ramirez Sebastian, Jose Manuel |
Documentos disponibles escritos por este autor (38)
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Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Cadena Santoyo, Manuel ; Elvira Hurtado, Lorena ; Salazar Corral, Juan José ; Hoz Montañana, Rosa de ; Ramirez Sebastian, Jose Manuel | Frontiers Media | 2020-09-25Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes degeneration of the lower and upper motor neurons and is the most prevalent motor neuron disease. This disease is characterized by muscle weakness, stiffness, and hyp[...]texto impreso
García Martín, Elena Salobrar ; Hoyas, Irene ; Leal, Mercedes ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Yubero Pancorbo, Raquel ; Gil, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Hindawi Publising Corp. | 2015-06-08Decreased thickness of the retinal nerve fiber layer (RNFL) may reflect retinal neuronal-ganglion cell death. A decrease in the RNFL has been demonstrated in Alzheimer’s disease (AD) in addition to aging by optical coherence tomography (OCT). Tw[...]texto impreso
Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa, de ; García Martín, Elena Salobrar ; Rojas, Pilar ; Fernández Arrabal, José A. ; López Cuenca, Inés ; Rojas López, Blanca ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | IntechOpen | 2018-11The optic nerve (ON) is constituted by the axons of the retinal ganglion cells (RGCs). These axons are distributed in an organized pattern from the soma of the RGC to the lateral geniculated nucleus (where most of the neurons synapse). The key p[...]texto impreso
Gracia Pacheco, Pablo de ; Gallego Collado, Beatriz Isabel ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Salazar Corral, Juan José ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Public Library of Science | 2015-11-18Proliferation of microglial cells has been considered a sign of glial activation and a hallmark of ongoing neurodegenerative diseases. Microglia activation is analyzed in animal models of different eye diseases. Numerous retinal samples are requ[...]texto impreso
Fernández Albarral, José Antonio ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Pinazo Durán, Mª Dolores ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | Medknow Publications | 2020-01-28Saffron (Crocus sativus L.) has been traditionally used in food preparation and as a medicinal plant. It currently has numerous therapeutic properties attributed to it, such as protection against ischemia, as well as anticonvulsant, antidepressa[...]texto impreso
Rojas Lozano, Pilar ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; Ferreras, Antonio ; García Martín, Elena Salobrar ; Muñóz Blanco, José L ; Urcelay Segura, José Luis ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI AG | 2019-12Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disabi[...]texto impreso
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Bravo Alcobendas, Noelia ; Zulueta, Joseba ; García Martín, Elena Salobrar ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | International Journal of Medical Students | 2015-09The purpose of this paper is to conduct a review of studies on cystoid macular edema published in the last seven years. Cystoid macular edema is a major cause of loss of visual acuity. It is the final common pathway of many diseases and can be c[...]texto impreso
Ramos Cordero, Primitivo ; Serrano Garijo, Pilar ; Tena-Dávila Mata, Mª Cruz ; Nieto López-Guerrero, Jerónimo ; Romero Chaparro, Rosario ; García Carpio, María del Sol ; Rojos Mateo, Begoña ; Ramirez Sebastian, Jose Manuel ; Triviño Casado, Alberto ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, Blanca ; García Merino, José Ignacio ; Jover Ibarra, José ; Aguirre Martín-Gil, Ramón ; Pinto Fontanillo, José Antonio | Consejería de Sanidad - D. G. de Salud Pública | 2007Este documento, que constituye el nº 8 de la colección Promoción de la salud en las personas mayores, pretende abordar buena parte de los problemas de salud de este colectivo aportando criterios y metodología para la intervención a sus cuidadore[...]texto impreso
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A través de los años, los científicos han indagado sobre el concepto de que "los ojos son el espejo del alma”, en busca de evidencias científicas que determinen si la investigación ocular podría ser útil para la investigación del cerebro y el [...]texto impreso
García Antón, María Teresa ; Salazar Corral, Juan José ; Hoz Montañana, Rosa de ; Rojas López, Blanca ; Ramírez Sebastián, Ana Isabel ; Triviño Casado, Alberto ; Aroca Aguilar, José Daniel ; García Feijoo, Julián ; Escribano, Julio ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2017-04-27Mutations in the CYP1B1 gene are currently the main known genetic cause of primary congenital glaucoma (PCG), a leading cause of blindness in children. Here, we analyze for the first time the CYP1B1 genotype activity and the microscopic and clin[...]texto impreso
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Gallego Collado, Beatriz Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salinas Navarro, Manuel Ángel ; Ortín Martínez, Arturo ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Biomed Central Ltd | 2012-05-12Background Ocular hypertension is a major risk factor for glaucoma, a neurodegenerative disease characterized by an irreversible decrease in ganglion cells and their axons. Macroglial and microglial cells appear to play an important role in the [...]texto impreso
Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Gallego Collado, Beatriz Isabel ; García Martín, Elena Salobrar ; Valiente Soriano, Francisco Javier ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Elsevier | 2015Most studies employing experimental models of unilateral glaucoma have used the normotensive contralateral eye as the normal control. However, some studies have recently reported the activation of the retinal macroglia and microglia in the uninj[...]texto impreso
Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ruiz, Emilio ; Tejerina Sánchez, Teresa ; Ramirez Sebastian, Jose Manuel ; Triviño Casado, Alberto | Elsevier | 2006-09-26This study evaluates hypercholesterolemic rabbits, examining the retinal changes in Müller cells and astrocytes as well as their variations after a period of normal blood-cholesterol values induced by a standard diet. New Zealand rabbits were di[...]texto impreso
García Martín, Elena Salobrar ; Rojas López, Blanca ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, Rosa de ; Salazar Corral, Juan José ; Yubero Pancorbo, Raquel ; Gil, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Elsevier / American Academy of Ophthalmology | 2014-03-18Although several postmortem findings in the retina of patients with Alzheimer's disease (AD) are available, new biomarkers for early diagnosis and follow-up of AD are still lacking. It has been postulated that the defects in the retinal nerve fi[...]texto impreso
López Cuenca, Inés ; Hoz Montañana, Rosa de ; García Martín, Elena Salobrar ; Elvira Hurtado, Lorena ; Rojas Lozano, Pilar ; Fernández Albarral, José Antonio ; Barabash, Ana ; Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Ramirez Sebastian, Jose Manuel | MDPI | 2020-06-03In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 y[...]texto impreso
Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; Hoz Montañana, Rosa de ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Rojas Lozano, Pilar ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | Elsevier | 2020Glaucoma is an age-related neurodegenerative disease that begins at the onset of aging. In this disease, there is an involvement of the immune system and therefore of the microglia. The purpose of this study is to evaluate the microglial activat[...]texto impreso
Fernández Albarral, José Antonio ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, Rosa de ; López Villarín, Nerea ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Licastro, Ester ; Inarejos García, Antonio M. ; Almodóvar, Paula ; Pinazo Durán, Mª Dolores ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | MDPI | 2019-08-22Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs). An increase in the intraocular pressure is the principal risk factor for such loss, but controlling this pressure does not always prevent glaucom[...]texto impreso
Fernández Navarro, Judith ; Aldea Mansilla, Pilar ; Hoz Montañana, María Rosa de ; Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Rojas López, Blanca ; Gallego Collado, Beatriz Isabel ; Triviño Casado, Alberto ; Tejerina Sánchez, Teresa ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2016-05-04To evaluate the pleiotropic effects to statins, we analyze the qualitative and quantitative retinal changes in hypercholesterolemic rabbits after a low-dosage statin treatment. For this purpose, New Zealand rabbits were split into three groups: [...]texto impreso
Andrés Guerrero, Vanessa ; Zong, Mengmeng ; Ramsay, Eva ; Rojas López, Blanca ; Sarkhel, Sanjay ; Gallego Collado, Beatriz Isabel ; Hoz Montañana, Rosa de ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel ; Amo, Eva M. del ; Cameron, Neil ; Las Heras Polo, Beatriz de ; Urtti, Arto ; Mihov, George ; Dias, Aylvin ; Herrero Vanrell, Rocío | Elsevier | 2015-08-10Most of the posterior segment diseases are chronic and multifactorial and require long-term intraocular medication. Conventional treatments of these pathologies consist of successive intraocular injections, which are associated with adverse effe[...]texto impreso
García Martín, Elena Salobrar ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Rojas Lozano, Pilar ; López Cuenca, Inés ; Fernández Albarral, José Antonio ; Ramirez Sebastian, Jose Manuel | Codon Publications | 2019-12-20The retina is part of the central nervous system (CNS), and therefore, in Alzheimer’s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed[...]texto impreso
Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Cadena Santoyo, Manuel ; Ferreras Amez, Antonio ; Monsalve Córdova, Blanca ; García Martín, Elena Salobrar ; Muñóz Blanco, José L ; Urcelay Segura, José Luis ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020-01-29Background: This study compared functional and structural visual changes in Friedreich ataxia (FRDA) patients with healthy controls (HC) and correlated these changes with neurological disability. Methods: Eight FRDA Spanish patients and eight HC[...]texto impreso
García Martín, Elena Salobrar ; Méndez Hernández, Carmen D. ; Hoz Montañana, Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; Fernández Arrabal, José A. ; Rojas Lozano, Pilar ; Wang, Surina ; García Feijoo, Julián ; Gil, Pedro ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020In Alzheimer’s disease (AD), vascular changes could be caused by amyloid beta (A?) aggregates replacing the contractile smooth musculature of the arteriole walls. These changes happen in the brain vascular network, but also in the eye, and are r[...]