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Autor Ramirez Sebastian, Jose Manuel |
Documentos disponibles escritos por este autor (38)
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Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ruiz, Emilio ; Tejerina Sánchez, Teresa ; Ramirez Sebastian, Jose Manuel ; Triviño Casado, Alberto | Elsevier | 2006-09-26This study evaluates hypercholesterolemic rabbits, examining the retinal changes in Müller cells and astrocytes as well as their variations after a period of normal blood-cholesterol values induced by a standard diet. New Zealand rabbits were di[...]![]()
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García Martín, Elena Salobrar ; Rojas López, Blanca ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, Rosa de ; Salazar Corral, Juan José ; Yubero Pancorbo, Raquel ; Gil, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Elsevier / American Academy of Ophthalmology | 2014-03-18Although several postmortem findings in the retina of patients with Alzheimer's disease (AD) are available, new biomarkers for early diagnosis and follow-up of AD are still lacking. It has been postulated that the defects in the retinal nerve fi[...]![]()
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López Cuenca, Inés ; Hoz Montañana, Rosa de ; García Martín, Elena Salobrar ; Elvira Hurtado, Lorena ; Rojas Lozano, Pilar ; Fernández Albarral, José Antonio ; Barabash, Ana ; Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Ramirez Sebastian, Jose Manuel | MDPI | 2020-06-03In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 y[...]![]()
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Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; Hoz Montañana, Rosa de ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Rojas Lozano, Pilar ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | Elsevier | 2020Glaucoma is an age-related neurodegenerative disease that begins at the onset of aging. In this disease, there is an involvement of the immune system and therefore of the microglia. The purpose of this study is to evaluate the microglial activat[...]![]()
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Fernández Albarral, José Antonio ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, Rosa de ; López Villarín, Nerea ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Licastro, Ester ; Inarejos García, Antonio M. ; Almodóvar, Paula ; Pinazo Durán, Mª Dolores ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | MDPI | 2019-08-22Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs). An increase in the intraocular pressure is the principal risk factor for such loss, but controlling this pressure does not always prevent glaucom[...]![]()
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Fernández Navarro, Judith ; Aldea Mansilla, Pilar ; Hoz Montañana, María Rosa de ; Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Rojas López, Blanca ; Gallego Collado, Beatriz Isabel ; Triviño Casado, Alberto ; Tejerina Sánchez, Teresa ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2016-05-04To evaluate the pleiotropic effects to statins, we analyze the qualitative and quantitative retinal changes in hypercholesterolemic rabbits after a low-dosage statin treatment. For this purpose, New Zealand rabbits were split into three groups: [...]![]()
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Andrés Guerrero, Vanessa ; Zong, Mengmeng ; Ramsay, Eva ; Rojas López, Blanca ; Sarkhel, Sanjay ; Gallego Collado, Beatriz Isabel ; Hoz Montañana, Rosa de ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel ; Amo, Eva M. del ; Cameron, Neil ; Las Heras Polo, Beatriz de ; Urtti, Arto ; Mihov, George ; Dias, Aylvin ; Herrero Vanrell, Rocío | Elsevier | 2015-08-10Most of the posterior segment diseases are chronic and multifactorial and require long-term intraocular medication. Conventional treatments of these pathologies consist of successive intraocular injections, which are associated with adverse effe[...]![]()
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García Martín, Elena Salobrar ; Hoz Montañana, María Rosa de ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Rojas Lozano, Pilar ; López Cuenca, Inés ; Fernández Albarral, José Antonio ; Ramirez Sebastian, Jose Manuel | Codon Publications | 2019-12-20The retina is part of the central nervous system (CNS), and therefore, in Alzheimer’s disease (AD), retinal and optic nerve degeneration could take place. This degeneration leads to neurofunctional changes that can be detected early and followed[...]![]()
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Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Cadena Santoyo, Manuel ; Ferreras Amez, Antonio ; Monsalve Córdova, Blanca ; García Martín, Elena Salobrar ; Muñóz Blanco, José L ; Urcelay Segura, José Luis ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020-01-29Background: This study compared functional and structural visual changes in Friedreich ataxia (FRDA) patients with healthy controls (HC) and correlated these changes with neurological disability. Methods: Eight FRDA Spanish patients and eight HC[...]![]()
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García Martín, Elena Salobrar ; Méndez Hernández, Carmen D. ; Hoz Montañana, Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; Fernández Arrabal, José A. ; Rojas Lozano, Pilar ; Wang, Surina ; García Feijoo, Julián ; Gil, Pedro ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020In Alzheimer’s disease (AD), vascular changes could be caused by amyloid beta (A?) aggregates replacing the contractile smooth musculature of the arteriole walls. These changes happen in the brain vascular network, but also in the eye, and are r[...]![]()
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García Martín, Elena Salobrar ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Yubero Pancorbo, Raquel ; Gil Gregorio, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Hindawi Publishing Corporation | 2015-05-20Purpose. To analyze in mild Alzheimer's disease (MAD) patients, GDS-4 (Reisberg Scale), whether or not some psychophysical tests (PTs) support OCT macular findings in the same group of MAD patients reported previously. Methods. Twenty-three MAD [...]![]()
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Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Cadena Santoyo, Manuel ; Fernández Arrabal, José A. ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Santos García, Irene ; Lago Femia, Eva de ; Urcelay Segura, José Luis ; Ramirez Sebastian, Jose Manuel ; Hoz Montañana, Rosa de ; Salazar Corral, Juan José | MDPI | 2021-02-07The neurodegenerative disease amyotrophic lateral sclerosis (ALS) affects the spinal cord, brain stem, and cerebral cortex. In this pathology, both neurons and glial cells are affected. However, few studies have analyzed retinal microglia in ALS[...]![]()
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Fernández Arrabal, José A. ; García Martín, Elena Salobrar ; Martínez Páramo, Rebeca ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | Elsevier | 2018-10-28Alzheimer's disease (AD) is a neurodegenerative dementia characterized by the deposition of extracellular ?-amyloid (A?) plaques and the presence of neurofibrillary tangles. Until now, the techniques used to analyze these deposits have been diff[...]![]()
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Hoz Montañana, Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Gallego Collado, Beatriz Isabel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Hindawi Publishing Corporation | 2016-04-14Due to their permanent and close proximity to neurons, glial cells perform essential tasks for the normal physiology of the retina. Astrocytes andM¨uller cells (retinal macroglia) provide physical support to neurons and supplement them with seve[...]![]()
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Fernández Arrabal, José A. ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Marco López, Eva María ; Martín Sánchez, Beatriz ; Flores Salguero, Elena ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Barrios Sabador, Vicente ; Avilés Trigueros, Marcelino ; Valiente Soriano, Francisco Javier ; Miralles de Imperial-Ollero, Juan A. ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel ; López Gallardo, Meritxell ; Ramírez Sebastián, Ana Isabel | MDPI | 2021-02-19Signaling mediated by cytokines and chemokines is involved in glaucoma-associated neuroinflammation and in the damage of retinal ganglion cells (RGCs). Using multiplexed immunoassay and immunohistochemical techniques in a glaucoma mouse model at[...]