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Título:
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Management of corneal neurotrophic ulcers with Cacicol®-RGTA (ReGeneraTing Agent): a case series
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Autores:
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Salazar Quiñones, Liseth ;
Molero Senosiain, Mercedes ;
Aguilar Munoa, Soledad ;
Gegúndez Fernández, José Antonio ;
Díaz Valle, David ;
Muñóz Hernández, Ana María ;
Benítez del Castillo, José Manuel
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Tipo de documento:
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texto impreso
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Editorial:
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Elsevier, 2020-06-17
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Dimensiones:
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application/pdf
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Nota general:
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cc_by_nc_nd
info:eu-repo/semantics/embargoedAccess
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Idiomas:
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Palabras clave:
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Estado = En prensa
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Materia = Ciencias Biomédicas: Medicina: Oftalmología
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Materia = Ciencias Biomédicas: Farmacia: Medicamentos
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Tipo = Artículo
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Resumen:
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Purpose: Neurotrophic corneal ulcers are difficult to treat, and the conventional treatment often results in failure. A new matrix regenerating agent (“ReGeneraTing Agents”), Cacicol® (Laboratoires Théa), has demonstrated good results over the last few years. Therefore, the aim of this study was to evaluate the response to Cacicol® in a series of cases with neurotrophic corneal ulcers. Methods: Retrospective case series looking at 11 patients with corneal ulcers unresponsive to conventional therapy that underwent treatment with Cacicol®. One cycle included 1 drop every two days for 5 days. Results: The range of conventional therapy prior to Cacicol® was 0-91 days. On introducing Cacicol® 82% (9/11) of the cases were cured, and 18% (2/11) failed, requiring an amniotic membrane transplant or penetrating keratoplasty. The healing only required one cycle of Cacicol® in 67% (6/9) of the patients. More than one cycle of Cacicol® was needed in 45% (5/11) patients. One corneal bacterial ulcer responded favourably and one case related to Acanthamoeba did not respond. Most of the patients improved or maintained their visual acuity. Conclusion: Cacicol® was a useful therapy in a high number of difficult neurotrophic corneal ulcers, including corneal infections. Some cases may require more than one cycle of Cacicol® or used as first-line treatment in order to achieve the desired result.
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En línea:
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https://eprints.ucm.es/id/eprint/61733/1/Gegundez_2020_1-s2.0-S2173579420301031-main.pdf
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