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Título:
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Neuroprotective role of sphingosine-1-phosphate in L-BMAA treated neuroblastoma cells (SH-SY5Y)
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Autores:
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Muñoz Sáez, Emma ;
Munck García, Estefanía de ;
Arahuetes Portero, Rosa María ;
Vicente, Francisca ;
Ortiz López, Francisco Javier ;
Cantizani, Juan ;
Gómez Miguel, Begoña
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Tipo de documento:
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texto impreso
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Editorial:
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Elsevier, 2015-04-23
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Dimensiones:
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application/pdf
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Nota general:
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info:eu-repo/semantics/restrictedAccess
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Idiomas:
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Palabras clave:
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Estado = Publicado
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Materia = Ciencias Biomédicas: Biología
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Materia = Ciencias Biomédicas: Biología: Biología molecular
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Tipo = Artículo
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Resumen:
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Sphingosine-1-phosphate (S1P) is a bioactive lipid which regulates proliferation, cell migration, survival and differentiation by specific receptors activation. We studied its effects on L-BMAA treated neuroblastoma cells (SH-SY5Y), an amino acid that can trigger neurodegenerative diseases such as amyotrophic lateral sclerosis/Parkinson dementia complex (ALS/PDC). We found that S1P protects from necrosis and prevents the GSK3 increasing as long as the PI3K/AKT pathway is active. Moreover, GSK3 inhibition protects against neuronal death caused by L-BMAA.
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En línea:
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https://eprints.ucm.es/43232/1/Miguel.%202015.%20Neuroprotective%20role%20of%20sphingosine%201%20phosphate%20in%20L%20BMAA%20treated%20neuroblastoma%20cells%20%28SH-SY5Y%29.pdf
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