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Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Cadena Santoyo, Manuel ; Elvira Hurtado, Lorena ; Salazar Corral, Juan José ; Hoz Montañana, Rosa de ; Ramirez Sebastian, Jose Manuel | Frontiers Media | 2020-09-25Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes degeneration of the lower and upper motor neurons and is the most prevalent motor neuron disease. This disease is characterized by muscle weakness, stiffness, and hyp[...]texto impreso
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Se ha estudiado la morfología y distribución de la infracción coloidea en el conejo albino. Mediante tecnicas argenticas e inmunodetenciones de la proteína gfa y neurofilamentos en montajes planos de coroides. Se encuentran dos tipos de fibras n[...]texto impreso
García Antón, María Teresa ; Salazar Corral, Juan José ; Hoz Montañana, Rosa de ; Rojas López, Blanca ; Ramírez Sebastián, Ana Isabel ; Triviño Casado, Alberto ; Aroca Aguilar, José Daniel ; García Feijoo, Julián ; Escribano, Julio ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2017-04-27Mutations in the CYP1B1 gene are currently the main known genetic cause of primary congenital glaucoma (PCG), a leading cause of blindness in children. Here, we analyze for the first time the CYP1B1 genotype activity and the microscopic and clin[...]texto impreso
García Martín, Elena Salobrar ; Rojas López, Blanca ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, Rosa de ; Salazar Corral, Juan José ; Yubero Pancorbo, Raquel ; Gil, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Elsevier / American Academy of Ophthalmology | 2014-03-18Although several postmortem findings in the retina of patients with Alzheimer's disease (AD) are available, new biomarkers for early diagnosis and follow-up of AD are still lacking. It has been postulated that the defects in the retinal nerve fi[...]texto impreso
López Cuenca, Inés ; Hoz Montañana, Rosa de ; García Martín, Elena Salobrar ; Elvira Hurtado, Lorena ; Rojas Lozano, Pilar ; Fernández Albarral, José Antonio ; Barabash, Ana ; Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Ramirez Sebastian, Jose Manuel | MDPI | 2020-06-03In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 y[...]texto impreso
Ramírez Sebastián, Ana Isabel ; Fernández Albarral, José Antonio ; Hoz Montañana, Rosa de ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Rojas Lozano, Pilar ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | Elsevier | 2020Glaucoma is an age-related neurodegenerative disease that begins at the onset of aging. In this disease, there is an involvement of the immune system and therefore of the microglia. The purpose of this study is to evaluate the microglial activat[...]texto impreso
Fernández Albarral, José Antonio ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, Rosa de ; López Villarín, Nerea ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Licastro, Ester ; Inarejos García, Antonio M. ; Almodóvar, Paula ; Pinazo Durán, Mª Dolores ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | MDPI | 2019-08-22Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs). An increase in the intraocular pressure is the principal risk factor for such loss, but controlling this pressure does not always prevent glaucom[...]texto impreso
Andrés Guerrero, Vanessa ; Zong, Mengmeng ; Ramsay, Eva ; Rojas López, Blanca ; Sarkhel, Sanjay ; Gallego Collado, Beatriz Isabel ; Hoz Montañana, Rosa de ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel ; Amo, Eva M. del ; Cameron, Neil ; Las Heras Polo, Beatriz de ; Urtti, Arto ; Mihov, George ; Dias, Aylvin ; Herrero Vanrell, Rocío | Elsevier | 2015-08-10Most of the posterior segment diseases are chronic and multifactorial and require long-term intraocular medication. Conventional treatments of these pathologies consist of successive intraocular injections, which are associated with adverse effe[...]texto impreso
García Martín, Elena Salobrar ; Méndez Hernández, Carmen D. ; Hoz Montañana, Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; Fernández Arrabal, José A. ; Rojas Lozano, Pilar ; Wang, Surina ; García Feijoo, Julián ; Gil, Pedro ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020In Alzheimer’s disease (AD), vascular changes could be caused by amyloid beta (A?) aggregates replacing the contractile smooth musculature of the arteriole walls. These changes happen in the brain vascular network, but also in the eye, and are r[...]texto impreso
Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Cadena Santoyo, Manuel ; Fernández Arrabal, José A. ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Santos García, Irene ; Lago Femia, Eva de ; Urcelay Segura, José Luis ; Ramirez Sebastian, Jose Manuel ; Hoz Montañana, Rosa de ; Salazar Corral, Juan José | MDPI | 2021-02-07The neurodegenerative disease amyotrophic lateral sclerosis (ALS) affects the spinal cord, brain stem, and cerebral cortex. In this pathology, both neurons and glial cells are affected. However, few studies have analyzed retinal microglia in ALS[...]texto impreso
Hoz Montañana, Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Gallego Collado, Beatriz Isabel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Hindawi Publishing Corporation | 2016-04-14Due to their permanent and close proximity to neurons, glial cells perform essential tasks for the normal physiology of the retina. Astrocytes andM¨uller cells (retinal macroglia) provide physical support to neurons and supplement them with seve[...]texto impreso
López Cuenca, Inés ; Hoz Montañana, Rosa de ; García Martín, Elena Salobrar ; Rojas López, Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Viguera Editores S.L. | 2017-06-01Introducción. El situs inversus del nervio óptico es una anomalía congénita caracterizada por la emergencia de los vasos de la retina en dirección nasal en lugar de temporal. Es causado por una anómala inserción del tallo óptico en la vesícula ó[...]texto impreso
García Martín, Elena Salobrar ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, Rosa de ; Rojas, Pilar ; Salazar Corral, Juan José ; Rojas López, Blanca ; Yubero Pancorbo, Raquel ; Gil, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Intech | 2016-09-28Over the last few decades, the importance of ophthalmic examination in neurodegenerative diseases of the CNS has reportedly increased. The retina is an extension of the CNS and thus should not be surprising to find abnormal results in both the t[...]
