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Sánchez Bretaño, Aída ; Gueguen, Marie-M. ; Cano-Nicolau, Joel ; Kah, Olivier ; Alonso Gómez, Ángel Luis ; Delgado Saavedra, María Jesús ; Isorna Alonso, Esther | Taylor & Francis | 2015-07-14The functional organization of the circadian system and the location of the main circadian oscillators vary through phylogeny. Present study investigates by in situ hybridization the anatomical location of the clock gene gPer1b in forebrain and [...]texto impreso
Blanco Imperiali, Ayelén M. ; Sánchez Bretaño, Aída ; Delgado Saavedra, María Jesús ; Valenciano González, Ana Isabel | Wiley Periodicals | 2016Ghrelin O-acyltransferase (GOAT) is the enzyme responsible for acylation of ghrelin, a gut-brain hormone with important roles in many physiological functions in vertebrates. Many aspects of GOAT remain to be elucidated, especially in fish, and p[...]texto impreso
Blanco Imperiali, Ayelén M. ; Cortés, Raul ; Bertucci, Juan Ignacio ; Sánchez, Elisa ; Valenciano González, Ana Isabel ; Cerdá-Reverter, José Miguel ; Delgado Saavedra, María Jesús | Springer | 2020-02Ghrelin (GRL) is a gut-brain hormone with a role in a wide variety of physiological functions in mammals and fish, which points out the ghrelinergic system as a key element for the appropriate biological functioning of the organism. However, man[...]texto impreso
Blanco Imperiali, Ayelén M. ; Gómez Boronat, Miguel ; Alonso Gómez, Ángel Luis ; Yufa, Roman ; Unniappan, Suraj ; Delgado Saavedra, María Jesús ; Valenciano González, Ana Isabel | Public Library of Science | 2017-02-08Ghrelin is the only known hormone posttranslationally modified with an acylation. This modification is crucial for most of ghrelin’s physiological effects and is catalyzed by the polytopic enzyme ghrelin O-acyltransferase (GOAT). The aim of this[...]texto impreso
Gómez-Boronat, Miguel ; Isorna Alonso, Esther ; Armirotti, Andrea ; Delgado Saavedra, María Jesús ; Piomelli, Danielle ; Pedro Ormeño, Nuria de | Frontiers Media | 2019-05-07N-acylethanolamines (NAEs) are a family of endogenous lipid signaling molecules that are involved in regulation of energy homeostasis in vertebrates with a putative role on circadian system. The aim of this work was to study the existence of dai[...]texto impreso
Blanco Imperiali, Ayelén M. ; Gómez-Boronat, Miguel ; Madera, Diego ; Valenciano González, Ana Isabel ; Alonso Gómez, Ángel Luis ; Delgado Saavedra, María Jesús | American Physiological Society | 2018-02Nocturnin (NOC) is a unique deadenylase with robust rhythmic expression involved in the regulation of metabolic processes in mammals. Currently, the possible presence of NOC in fish is unknown. This report aimed to identify NOC in a fish model, [...]texto impreso
Gómez-Boronat, Miguel ; Isorna Alonso, Esther ; Conde-Sieira, Marta ; Delgado Saavedra, María Jesús ; Soengas, José L. ; Pedro Ormeño, Nuria de | Elsevier | 2020-01The objective of this study was to investigate the role of palmitoylethanolamide (PEA) in the regulation of energy homeostasis in goldfish (Carassius auratus). We examined the effects of acute or chronic intraperitoneal treatment with PEA (20 ?g[...]texto impreso
Blanco Imperiali, Ayelén M. ; Bertucci, Juan I. ; Ramesh, Naresh ; Delgado Saavedra, María Jesús ; Valenciano González, Ana Isabel ; Unniappan, Suraj | Springer Nature | 2017-03-24Glucose homeostasis is an important biological process that involves a variety of regulatory mechanisms. This study aimed to determine whether ghrelin, a multifunctional gut-brain hormone, modulates intestinal glucose transport in goldfish (Cara[...]texto impreso
Sánchez Bretaño, Aída ; Blanco Imperiali, Ayelén M. ; Alonso Gómez, Ángel Luis ; Delgado Saavedra, María Jesús ; Kah, Olivier ; Isorna Alonso, Esther | The Company of Biologists | 2017The liver is the most important link between the circadian system and metabolism. As a food-entrainable oscillator, the hepatic clock needs to be entrained by food-related signals. The objective of the present study was to investigate the possib[...]texto impreso
Blanco Imperiali, Ayelén M. ; Bertucci, Juan I. ; Sánchez Bretaño, Aída ; Delgado Saavedra, María Jesús ; Valenciano González, Ana Isabel ; Unniappan, Suraj | Elsevier | 2017-02-15Ghrelin, a multifunctional gut-brain hormone, is involved in the regulation of gastric functions in mammals. This study aimed to determine whether ghrelin modulates digestive enzymes in goldfish (Carassius auratus). Immunofluorescence microscopy[...]texto impreso
Delgado Saavedra, María Jesús ; Cerdá Reverter, José M. ; Soengas, José L. | Frontiers Media | 2017-06The regulation of food intake in fish is a complex process carried out through several different mechanisms in the central nervous system (CNS) with hypothalamus being the main regulatory center. As in mammals, a complex hypothalamic circuit inc[...]texto impreso
Nisembaum, Laura Gabriela ; Besseau, Laurence ; Paulin, CharleHubert s- ; Charpantier, Alice ; Martin, Patrick ; Magnanou, Elodie ; Fuentes, Michael ; Delgado Saavedra, María Jesús ; Falcón, Jack | Oxford University Press | 2015-12Photoperiod plays an essential role in the synchronization ofmetabolism, physiology, and behavior to the cyclic variations of the environment. In vertebrates, information is relayed by the pineal cells and translated into the nocturnal productio[...]texto impreso
Isorna Alonso, Esther ; Pedro Ormeño, Nuria de ; Valenciano González, Ana Isabel ; Alonso Gómez, Ángel Luis ; Delgado Saavedra, María Jesús | Bioscientifica | 2017-03The circadian system is responsible for the temporal organisation of physiological functions which, in part, involves daily cycles of hormonal activity. In this review, we analyse the interplay between the circadian and endocrine systems in fish[...]texto impreso
Sánchez Bretaño, Aída ; Callejo, María ; Montero, Marta ; Alonso Gómez, Ángel L. ; Delgado Saavedra, María Jesús ; Isorna Alonso, Esther | Springer Link | 2016Glucocorticoids have been recently proposed as input signals of circadian system, although the underlying molecular mechanism remains unclear. This work investigates the role of glucocorticoids as modulators of clock genes expression in the live[...]texto impreso
Blanco, Ayelén M. ; Gómez Boronat, Miguel ; Redondo, I. ; Valenciano González, Ana Isabel ; Delgado Saavedra, María Jesús | Springer Link | 2016The periprandial profile and effects of short- (7 days) and long-term (30 days) fasting on the ghrelinergic system were studied in goldfish (Carassius auratus). Plasma levels of acyl-ghrelin, desacyl-ghrelin, and ghrelin O-acyl transferase (GOAT[...]
