Información del autor
Documentos disponibles escritos por este autor (15)
Añadir el resultado a su cesta Hacer una sugerencia Refinar búsqueda
texto impreso
Rodríguez Peña, José Manuel ; Diez-Muñiz, Sonia ; Bermejo, Clara ; Nombela, César ; Arroyo, Javier | Elsevier | 2013-10-04Yeast adaptation to conditions in which cell wall integrity is compromised mainly relies on the cell wall integrity (CWI) mitogen-activated protein kinase (MAPK) pathway. Zymolyase, a mixture of cell wall-digesting enzymes, triggers a peculiar s[...]texto impreso
Reales Calderón, José Antonio ; Sylvester, Marc ; Strijbis, Karin ; Jensen, Ole N. ; Nombela, César ; Molero, Gloria ; Gil, Concha | Elsevier | 2013-07-05Macrophages play a pivotal role in the prevention of Candida albicans infections. Yeast recognition and phagocytosis by macrophages is mediated by Pattern Recognition Receptors (PRRs) that initiate downstream signal transduction cascades by prot[...]texto impreso
Vialás, Vital ; Perumal, Palani ; Gutierrez, Dolores ; Ximénez-Embún, Pilar ; Nombela, César ; Gil, Concha ; Chaffin, W. LaJean | http://onlinelibrary.wiley.com/doi/10.1002/pmic.201100588/abstract | 2012-08We used a brief trypsin treatment followed by peptide separation and identification using nano-LC followed by off-line MS/MS to identify the surface proteins on live Candida albicans organisms growing in biofilms and planktonic yeast cells and h[...]texto impreso
Sanz, A. Belén ; García, Raúl ; Rodríguez-Peña, José Manuel ; Diez-Muñiz, Sonia ; Nombela, César ; Peterson, Craig L. ; Arroyo, Javier | 2012-05-23In Saccharomyces cerevisiae, the transcriptional program triggered by cell wall stress is coordinated by Slt2/Mpk1, the mitogen-activated protein kinase (MAPK) of the cell wall integrity (CWI) pathway, and is mostly mediated by the transcription[...]texto impreso
Invasive Candidiasis (IC) poses a major public health problem worldwide. Despite the introduction of new antifungal agents and changes in clinical practices, its morbidity and mortality rates and healthcare costs remain persistently high. This i[...]texto impreso
Relloso, Miguel ; Aragoneses-Fenoll, Laura ; Lasarte, Sandra ; Bourgeois, Christelle ; Romera, Gema ; Kuchler, Karl ; Corbí, Ángel L. ; Muñoz-Fernández, M. Angeles ; Nombela, César ; Rodríguez-Fernández, José L. ; Díez-Orejas, Rosalia | Society for Leukocyte Biology | 2012-01Candida albicans is a commensal opportunistic pathogen that is also a member of gastrointestinal and reproductive tract microbiota. Exogenous factors, such as oral contraceptives, hormone replacement therapy, and estradiol, may affect susceptibi[...]texto impreso
Serrano Ruiz-Calderón, José Miguel ; Nombela, César ; Postigo Solana, Elena ; ABellan Salort, Jose ; Lopez Timoneda, Francisco ; Prensa Sepulveda, Lucía | 2008-09In view of the intense pressures being exerted on Spanish public opinion to induce it to consent to the legalization of assisted suicide and euthanasia, it is necessary to defend the dignity of natural death as the end of every human life. The [...]texto impreso
García Sanchez, Raul ; Botet, Javier ; Rodríguez Peña, José Manuel ; Bermejo, Clara ; Ribas, Juan Carlos ; Revuelta, José Luis ; Nombela, César ; Arroyo, Javier | BioMed Central | 2015-09-05BACKGROUND The fungal cell wall forms a compact network whose integrity is essential for cell morphology and viability. Thus, fungal cells have evolved mechanisms to elicit adequate adaptive responses when cell wall integrity (CWI) is compromise[...]texto impreso
Gil Bona, Ana ; Lla Palacios, Arancha ; Parra Giraldo, Claudia Marcela ; Vivando, F. ; Nombela, César ; Monteoliva Díaz, Lucía ; Gil, Concha | ACS | 2015Different signal transduction pathways mediated by MAP kinases have been described in Candida albicans. These pathways sense different stimuli and, therefore, elaborate specific responses. Hog1 was identified as the MAPK that is primarily involv[...]texto impreso
Invasive candidiasis (IC) adds significantly to the morbidity and mortality of non-neutropenic patients if not diagnosed and treated early. To uncover serologic biomarkers that alone or in combination could reliably detect IC in this population,[...]texto impreso
García, Raúl ; Pulido, Verónica ; Orellana Muñoz, Sara ; Nombela, César ; Vázquez de Aldana, Carlos R. ; Rodríguez Peña, José Manuel ; Arroyo, Javier | Nature Research | 2019-02-28Post-transcriptional control of mRNA is a key event in the regulation of gene expression. From yeast to human cells, P-bodies are cytoplasmic RNA-protein aggregates that play an essential role in this process, particularly under stress condition[...]texto impreso
Sanz Santamaría, Ana Belén ; García, Raúl ; Rodríguez Peña, José Manuel ; Nombela, César ; Arroyo Nombela, Francisco Javier | Elsevier | 2018-11The regulation of gene expression through the cell wall integrity (CWI) pathway in yeast is mainly coordinated by the MAPK Slt2 and the transcription factor Rlm1. In this work, we elucidate a new role for Slt2 as a part of the transcriptional ac[...]texto impreso
Blanco, Noelia ; Sanz, Ana Belén ; Rodríguez Peña, José Manuel ; Nombela, César ; Farkaš, Vladimír ; Hurtado Guerrero, Ramón ; Arroyo, Javier | Wiley | 2015-02Covalent cross-links between chitin and glucan at the yeast cell wall are created by the transglycosylase activity of redundant proteins Crh1 and Crh2, with cleavage of ?-1,4 linkages of the chitin backbone and transfer of the generated molecule[...]texto impreso
Reales Calderón, José Antonio ; Martínez Solano, Laura ; Martinez Gomariz, Montserrat ; Nombela, César ; Molero, Gloria ; Gil, Concha | Elsevier | 2012-08In previous proteomic studies on the response of murine macrophages against Candida albicans, many differentially expressed proteins involved in processes like inflammation, cytoskeletal rearrangement, stress response and metabolism were identif[...]texto impreso
Baquero, Fernando ; Nombela, César | European Society of Clinical Microbiology and Infectious Diseases | 2012The human organism is a complex structure composed of cells belonging to all three domains of life on Earth, Eukarya, Bacteria and Archaea, as well as their viruses. Bacterial cells of more than a thousand taxonomic units are condensed in a part[...]
