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Rodríguez Peña, José Manuel ; Diez-Muñiz, Sonia ; Bermejo, Clara ; Nombela, César ; Arroyo, Javier | Elsevier | 2013-10-04Yeast adaptation to conditions in which cell wall integrity is compromised mainly relies on the cell wall integrity (CWI) mitogen-activated protein kinase (MAPK) pathway. Zymolyase, a mixture of cell wall-digesting enzymes, triggers a peculiar s[...]texto impreso
Sanz, A. Belén ; García, Raúl ; Rodríguez-Peña, José Manuel ; Diez-Muñiz, Sonia ; Nombela, César ; Peterson, Craig L. ; Arroyo, Javier | 2012-05-23In Saccharomyces cerevisiae, the transcriptional program triggered by cell wall stress is coordinated by Slt2/Mpk1, the mitogen-activated protein kinase (MAPK) of the cell wall integrity (CWI) pathway, and is mostly mediated by the transcription[...]texto impreso
Blanco, Noelia ; Reidy, Michael ; Arroyo, Javier ; Cabib, Enrico | 2012-10-17Previous work has shown that, in cla4? cells of budding yeast, where septin ring organization is compromised, the chitin ring at the mother-daughter neck becomes essential for prevention of neck widening and for cytokinesis. Here, we show that i[...]texto impreso
García Sanchez, Raul ; Botet, Javier ; Rodríguez Peña, José Manuel ; Bermejo, Clara ; Ribas, Juan Carlos ; Revuelta, José Luis ; Nombela, César ; Arroyo, Javier | BioMed Central | 2015-09-05BACKGROUND The fungal cell wall forms a compact network whose integrity is essential for cell morphology and viability. Thus, fungal cells have evolved mechanisms to elicit adequate adaptive responses when cell wall integrity (CWI) is compromise[...]texto impreso
MARQ: an online tool to mine GEO for experiments with similar or opposite gene expression signatures
Vázquez, Miguel ; Nogales Cadenas, Rubén ; Arroyo, Javier ; Botias, Pedro ; García, Raúl ; Carazo, José M. ; Tirado Fernández, Francisco ; Pascual Montano, Alberto ; Carmona Saez, Pedro | Oxford Univ Press | 2010-07Medical imaging has become an absolutely essential diagnostic tool for clinical practices; at present, pathologies can be detected with an earliness never before known. Its use has not only been relegated to the field of radiology but also, incr[...]texto impreso
Fang, Wenxia ; Sanz Santamaría, Ana Belén ; Bartual, Sergio Galan ; Wang, Bin ; Ferenbach, Andrew T. ; Farkaš, Vladimír ; Hurtado Guerrero, Ramón ; Arroyo, Javier ; Van Aalten, Daan M. F. | Nature Research | 2019-04-10Fungal cell wall synthesis is achieved by a balance of glycosyltransferase, hydrolase and transglycosylase activities. Transglycosylases strengthen the cell wall by forming a rigid network of crosslinks through mechanisms that remain to be explo[...]texto impreso
Zelante, Teresa ; Iannitti, Rossana G. ; De Luca, Antonella ; Arroyo, Javier ; Blanco, Noelia ; Servillo, Giuseppe ; Sanglard, Dominique ; Reichard, Utz ; Palmer, Glen E. ; Latgè, Jean-Paul ; Puccetti, Paolo ; Romani, Luigina | Nature Publishing Group | 2012-02-21Infections by opportunistic fungi have traditionally been viewed as the gross result of a pathogenic automatism, which makes a weakened host more vulnerable to microbial insults. However, fungal sensing of a host's immune environment might rende[...]texto impreso
García, Raúl ; Pulido, Verónica ; Orellana Muñoz, Sara ; Nombela, César ; Vázquez de Aldana, Carlos R. ; Rodríguez Peña, José Manuel ; Arroyo, Javier | Nature Research | 2019-02-28Post-transcriptional control of mRNA is a key event in the regulation of gene expression. From yeast to human cells, P-bodies are cytoplasmic RNA-protein aggregates that play an essential role in this process, particularly under stress condition[...]texto impreso
Blanco, Noelia ; Sanz, Ana Belén ; Rodríguez Peña, José Manuel ; Nombela, César ; Farkaš, Vladimír ; Hurtado Guerrero, Ramón ; Arroyo, Javier | Wiley | 2015-02Covalent cross-links between chitin and glucan at the yeast cell wall are created by the transglycosylase activity of redundant proteins Crh1 and Crh2, with cleavage of ?-1,4 linkages of the chitin backbone and transfer of the generated molecule[...]texto impreso
Chauvin, David ; Hust, Michael ; Schütte, Mark ; Chesnay, Adélaïde ; Parent, Christelle ; Moreira, Gustavo Marçal Schmidt Garcia ; Arroyo, Javier ; Sanz Santamaría, Ana Belén ; Pugnière, Martine ; Martineau, Pierre ; Chandenier, Jacques ; Heuzé-Vourc'h, Nathalie ; Desoubeaux, Guillaume ; Parentani, R. | Frontiers Media | 2019-03-26is an airborne opportunistic fungal pathogen responsible for severe infections. Among them, invasive pulmonary aspergillosis has become a major concern as mortality rates exceed 50% in immunocompromised hosts. In parallel, allergic bronchopulmon[...]texto impreso
Chauvin, David ; Hust, Michael ; Schütte, Mark ; Chesnay, Adélaïde ; Parent, Christelle ; Moreira, Gustavo Marçal Schmidt Garcia ; Arroyo, Javier ; Sanz, Ana Belén ; Pugnière, Martine ; Martineau, Pierre ; Chandenier, Jacques ; Heuzé-Vourc'h, Nathalie ; Desoubeaux, Guillaume | Frontiers Media | 2019-03-26Aspergillus fumigatus is an airborne opportunistic fungal pathogen responsible for severe infections. Among them, invasive pulmonary aspergillosis has become a major concern as mortality rates exceed 50% in immunocompromised hosts. In parallel, [...]
