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Autor Sacristán Reviriego, Almudena |
Documentos disponibles escritos por este autor (3)
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Sacristán Reviriego, Almudena ; Madrid, Marisa ; Cansado, José ; Martín, Humberto ; Molina, María | Public Library of Science | 2014-01-22Dual-specificity MAPK phosphatases (MKPs) are essential for the negative regulation of MAPK pathways. Similar to other MAPK-interacting proteins, most MKPs bind MAPKs through specific docking domains known as D-motifs. However, we found that the[...]texto impreso
texto impreso
The lack of signaling through MAPK pathways leads to a defective cellular response to the corresponding stimulus, but an improper hyperactivation of these routes results in deleterious effects as well. Protein phosphorylation is an activating mo[...]