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Sacristán Reviriego, Almudena ; Madrid, Marisa ; Cansado, José ; Martín, Humberto ; Molina, María | Public Library of Science | 2014-01-22Dual-specificity MAPK phosphatases (MKPs) are essential for the negative regulation of MAPK pathways. Similar to other MAPK-interacting proteins, most MKPs bind MAPKs through specific docking domains known as D-motifs. However, we found that the[...]texto impreso
Martín, Humberto ; Shales, Michael ; Fernández-Piñar, Pablo ; Wei, Ping ; Molina, María ; Fiedler, Dorothea ; Shokat, Kevan M. ; Beltrao, Pedro ; Lim, Wendell ; Krogan, Nevan J. | EMBO Press | 2015-04-17Genetic interaction screens have been applied with great success in several organisms to study gene function and the genetic architecture of the cell. However, most studies have been performed under optimal growth conditions even though many fun[...]texto impreso
Rodríguez Escudero, Isabel ; Fernández Acero, Teresa ; Cid, Víctor J. ; Molina, María | Nature Research | 2018-05-16The Akt protein kinase is the main transducer of phosphatidylinositol-3,4,5-trisphosphate (PtdIns3,4,5P) signaling in higher eukaryotes, controlling cell growth, motility, proliferation and survival. By co-expression of mammalian class I phospha[...]texto impreso
Coronas Serna, Julia María ; Fernández Acero, Teresa ; Molina, María ; Cid, Víctor J. | Shared Science Publishers | 2018-11-12Phosphatidylinositol 3-kinase (PI3K) is a key regulator of phosphoinositide-dependent signaling in mammalian cells and its dysfunction is related to multiple syndromes, including cancer. By heterologous expression in , we have developed a humani[...]texto impreso
The lack of signaling through MAPK pathways leads to a defective cellular response to the corresponding stimulus, but an improper hyperactivation of these routes results in deleterious effects as well. Protein phosphorylation is an activating mo[...]texto impreso
Hernández Haro, Carolina ; Llopis, Silvia ; Molina, María ; Monteoliva Díaz, Lucía ; Gil, Concha | Elsevier | 2015-01-01Saccharomyces cerevisiae is considered a safe microorganism widely used as a dietary supplement. However, in the latest decades several cases of S. cerevisiae infections have been reported. Recent studies in a murine model of systemic infection [...]texto impreso
Llopis, Silvia ; Hernández Haro, Carolina ; Monteoliva Díaz, Lucía ; Querol, Amparo ; Molina, María ; Fernández Espinar, María T. | Public Library of Science | 2014-05-30Saccharomyces cerevisiae plays a beneficial role in health because of its intrinsic nutritional value and bio-functional properties, which is why it is also used as a dietary supplement. However, the perception that S. cerevisiae is harmless has[...]texto impreso
Mingo, Janire ; Rodríguez Escudero, Isabel ; Luna, Sandra ; Fernández Acero, Teresa ; Amo, Laura ; Jonasson, Amy R ; Zori, Roberto T ; López, José I ; Molina, María ; Cid, Víctor J. ; Pulido, Rafael | Springer Nature | 2018-04-30The PTEN gene encodes a master regulator protein that exerts essential functions both in the cytoplasm and in the nucleus. PTEN is mutated in the germline of both patients with heterogeneous tumor syndromic diseases, categorized as PTEN hamartom[...]texto impreso
Mascaraque, Victoria ; Hernaez, Maria Luisa ; Jiménez-Sánchez, María ; Hansen, Rasmus ; Gil, Concha ; Martín, Humberto ; Cid, Víctor J. ; Molina, María | 2013-03The cell wall integrity (CWI) pathway of the model organism Saccharomyces cerevisiae has been thoroughly studied as a paradigm of the mitogen-activated protein kinase (MAPK) pathway. It consists of a classic MAPK module comprising the Bck1 MAPK [...]texto impreso
Rodríguez Escudero, María ; Cid, Víctor J. ; Molina, María ; Schulze Luehrmann, Jan ; Lührmann, Anja ; Rodríguez Escudero, Isabel | 2016-01-28Coxiella burnetii is a Gram-negative obligate parasitic bacterium that causes the disease Q-fever in humans. To establish its intracellular niche, it utilizes the Icm/Dot type IVB secretion system (T4BSS) to inject protein effectors into the hos[...]texto impreso
Fernández-Piñar, Pablo ; Alemán, Ainel ; Sondek, John ; Dohlman, Henrik G. ; Molina, María ; Martín, Humberto | 2012-09-26Intracellular survival of Salmonella relies on the activity of proteins translocated into the host cell by type III secretion systems (T3SS). The protein kinase activity of the T3SS effector SteC is required for F-actin remodeling in host cells,[...]texto impreso
Fernández Acero, Teresa ; Rodríguez Escudero, Isabel ; Molina, María ; Cid, Víctor J. | Elsevier | 2015-08-07Phosphatidylinositol (4,5)-bisphosphate [PtdIns(4,5)P2] is essential for recognition of the plasma membrane inner leaf by protein complexes. We expressed mammalian class I phosphoinositide 3-kinase (PI3K) in Saccharomyces cerevisiae to eliminate[...]texto impreso
Pulido, Rafael ; Baker, Suzanne J. ; Barata, Joao T. ; Carracedo, Arkaitz ; Cid, Víctor J. ; Chin-Sang, Ian D. ; Davé, Vrushank ; Hertog, Jeroen den ; Devreotes, Peter ; Eickholt, Britta J. ; Eng, Charis ; Furnari, Frank B. ; Georgescu, María Magdalena ; Gericke, Arne ; Hopkins, Benjamin ; Jiang, Xeujun ; Lee, Seung Rock ; Lösche, Mathias ; Malaney, Prerna ; Matias Guiu, Xavier ; Molina, María ; Pandolfi, Pier Paolo ; Parsons, Ramon ; Pinton, Paolo ; Rivas, Carmen ; Rocha, Rafael M. ; Rodríguez, Manuel S. ; Ross, Alonzo H. ; Serrano, Manuel ; Stambolic, Vuk ; Stiles, Bangyan ; Suzuki, Akira ; Tan, Seong Seng ; Tonks, Nicholas K. ; Trotman, Lloyd C. ; Wolff, Nicolas ; Woscholski, Rudiger ; Wu, Hong ; Leslie, Nicholas R. | American Association for the Advancement of Science | 2014-07-01The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTE[...]texto impreso
Fernández Acero, Teresa ; Rodríguez Escudero, Isabel ; Vicente, Francisca ; Monteiro, Maria Cândida ; Tormo, José R. ; Cantizani, Juan ; Molina, María ; Cid, Víctor J. | 2012-06-15The phosphatidylinositol 3-kinase (PI3K) pathway couples receptor-mediated signaling to essential cellular functions by generating the lipid second messenger phosphatidylinositol-3,4,5-trisphosphate. This pathway is implicated in multiple aspect[...]texto impreso
Rodríguez Escudero, Isabel ; Fernández Acero, Teresa ; Bravo, Ignacio ; Leslie, Nicholas R. ; Pulido, Rafael ; Molina, María ; Cid, Víctor J. | Elsevier | 2015-05-01The PTEN phosphoinositide 3-phosphatase is a tumor suppressor commonly targeted by pathologic missense mutations. Subject to multiple complex layers of regulation, its capital role in cancer relies on its counteracting function of class I phosph[...]
