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Ruiz Calvo, Andrea ; Bajo-Grañeras, Raquel ; Maroto, Irene B. ; Zian, Debora ; Grabner, Gernot F. ; García-Taboada, Elena ; Resel, Eva ; Zechner, Rudolf ; Zimmermann, Robert ; Ortega-Gutiérrez, Silvia ; Galve Roperh, Ismael ; Bellocchio, Luigi ; Guzmán, Manuel | Elsevier | 2019-05-15Cannabinoids exert neuroprotection in a wide array of preclinical models. A number of these studies has focused on cannabinoid CB1 receptors in striatal medium spiny neurons (MSNs) and the most characteristic MSN-degenerative disease, Huntington[...]texto impreso
Bravo Ferrer, Isbel ; Cuartero Desviat, María Isabel ; Zarruk, Juan G. ; Pradillo, Jesús M. ; Hurtado Moreno, Olivia ; Romera, Victor G. ; Díaz Alonso, Javier ; García Segura, Juan Manuel ; Guzmán, Manuel ; Lizasoaín, Ignacio ; Galve Roperh, Ismael ; Moro, María A. | American Heart Association | 2017-01Background and Purpose—Stroke is a leading cause of adult disability characterized by physical, cognitive, and emotional disturbances. Unfortunately, pharmacological options are scarce. The cannabinoid type-2 receptor (CB2R) is neuroprotective i[...]texto impreso
Díaz Alonso, Javier ; Aguado, Tania ; Salas Quiroga, Adán de ; Ortega, Zaira ; Guzmán, Manuel ; Galve Roperh, Ismael | Oxford University Press | 2015-09The CB1 cannabinoid receptor regulates cortical progenitor proliferation during embryonic development, but the molecular mechanism of this action remains unknown. Here, we report that CB1-deficient mouse embryos show premature cell cycle exit, d[...]texto impreso
García Rincón, Daniel ; Díaz Alonso, Javier ; Paraíso Luna, Juan ; Otega, Zaira ; Aguareles, José ; Salas Quiroga, Adán de ; Jou, Cristina ; Prada, Inmaculada de ; Martínez Cerdeño, Verónica ; Aronica, Eleonora ; Guzmán, Manuel ; Pérez-Jiménez, María Ángeles ; Galve Roperh, Ismael | Frontiers Media | 2019-01Alterations of the PI3K/Akt/mammalian target of rapamycin complex 1 (mTORC1) signaling pathway are causally involved in a subset of malformations of cortical development (MCDs) ranging from focal cortical dysplasia (FCD) to hemimegalencephaly an[...]texto impreso
Vicario de la Torre, Marta ; Benítez del Castillo, José Manuel ; Vico Ruiz, Eva ; Guzmán, Manuel ; Heras Polo, Beatriz de las ; Herrero Vanrell, Rocío ; Molina Martínez, Irene Teresa | Association for Research in Vision and Ophthalmology (ARVO) | 2014-12Purpose: Dry eye (DE) includes a group of diseases related to tear film disorders. Current trends for DE therapy focus on providing lipid components to replace the damaged lipid layer. Formulations that contain aqueous and mucin like compounds m[...]texto impreso
Hernández Tiedra, Sonia ; Fabriàs, Gemma ; Dávila, David ; Salanueva, Iñigo J. ; Casas, Josefina ; Montes, L.Ruth ; Antón, Zuriñe ; GarcíaTaboada, Elena ; Salazar Roa, María ; Lorente Pérez, Mar ; Nylandsted, Jesper ; Armstrong, Jane ; López Valero, Israel ; McKee, Christopher S. ; Serrano Puebla, Ana ; García López, Roberto ; González Martínez, José ; Abad, José L. ; Kentaro, Hanada ; Boya, Patricia ; Goñi, Félix ; Guzmán, Manuel ; Lovat, Penny ; Jäättelä, Marja ; Alonso, Alicia ; Velasco, Guillermo | Taylor & Francis | 2016-09-16Autophagy is considered primarily a cell survival process, although it can also lead to cell death. However, the factors that dictate the shift between these 2 opposite outcomes remain largely unknown. In this work, we used D9 -tetrahydrocannabi[...]texto impreso
Salas Quiroga, Adán de ; García-Rincón, Daniel ; Gómez-Domínguez, Daniel ; Valero, Manuel ; Simón-Sánchez, Samuel ; Paraíso-Luna, Juan ; Aguareles, José ; Pujadas, Mitona ; Muguruza, Carolina ; Callado, Luis F. ; Lutz, Beat ; Guzmán, Manuel ; Menéndez de la Prida, Liset ; Galve-Roperh, Manuel | Springer Nature | 2020-01-26Prenatal exposure to ?9 -tetrahydrocannabinol (THC), the most prominent active constituent of cannabis, alters neurodevelopmental plasticity with a long-term functional impact on adult offspring. Specifically, THC affects the development of pyra[...]texto impreso
Moreno-Delgado, David ; Puigdellívol, Mar ; Moreno, Moreno ; Rodríguez-Ruiz, Mar ; Botta, Joaquín ; Gasperini, Paola ; Chiarlone, Anna ; Howell, Lesley A. ; Scarselli, Marco ; Casadó, Vicent ; Cortés, Antoni ; Ferré, Sergi ; Guzmán, Manuel ; Lluís, Carmen ; Alberch, Jordi ; Canela, Enric I. ; Ginés, Silvia ; McCormick, Peter J. | eLife Sciences Publications | 2020-06-09Early Huntington’s disease (HD) include over-activation of dopamine D1 receptors (D1R), producing an imbalance in dopaminergic neurotransmission and cell death. To reduce D1R over-activation, we present a strategy based on targeting complexes of[...]texto impreso
Aguareles, José ; Paraíso Luna, Juan ; Palomares, Belén ; Bajo-Grañeras, Raquel ; Navarrete, Carmen ; Ruiz-Calvo, Andrea ; García Rincón, Daniel ; García-Taboada, Elena ; Guzmán, Manuel ; Muñoz, Eduardo ; Galve Roperh, Ismael | BMC | 2019-03-08Background: The administration of certain cannabinoids provides neuroprotection in models of neurodegenerative diseases by acting through various cellular and molecular mechanisms. Many cannabinoid actions in the nervous system are mediated by C[...]texto impreso
Salas Quiroga, Adán de ; Díaz Alonso, Javier ; García-Rincón, Daniel ; Remmers, Floortje ; Vega, David ; Gómez Cañas, María ; Lutz, Beat ; Guzmán, Manuel ; Galve Roperh, Ismael | National Academy of Sciences | 2015-11The CB1 cannabinoid receptor, the main target of ?9 -tetrahydrocannabinol (THC), the most prominent psychoactive compound of marijuana, plays a crucial regulatory role in brain development as evidenced by the neurodevelopmental consequences of i[...]texto impreso
Blasco-Benito, Sandra ; Moreno Gordaliza, Estefanía ; Seijo-Vila, Marta ; Tundidor, Isabel ; Andradas Arias, Clara ; Caffarel, María M. ; Caro-Villalobos, Miriam ; Urigüen, Leyre ; Diez-Alarcia, Rebeca ; Moreno-Bueno, Gema ; Hernández, Lucia ; Manso Sánchez, Luis Manuel ; Homar-Ruano, Patricia ; McCormick, Peter J. ; Bibic, Lucka ; Bernadó-Morales, Cristina ; Arribas, Joaquín ; Canals, Meritxell ; Casadó, Vicent ; Canela, Enric I. ; Guzmán, Manuel ; Pérez-Gómez, Eduardo ; Sánchez, Cristina | National Academy of Sciences (USA) | 2019-02-26Although human epidermal growth factor receptor 2 (HER2)- targeted therapies have dramatically improved the clinical outcome of HER2-positive breast cancer patients, innate and acquired resistance remains an important clinical challenge. New the[...]
