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Mela Rivas, Virginia ; Hernández, Oskarina ; Hunsche, Caroline ; Díaz, Francisca ; Chowen, Julie A. ; Fuente del Rey, Mónica de la | Elsevier | 2017-10-15The importance of the neonatal leptin surge in rodents in neurodevelopmental processes has aroused curiosity in its implication in other physiological systems. Given the role of leptin in neuro-immune interactions, we hypothesized that the neona[...]texto impreso
Hunsche, Caroline ; Hernández, Oskarina ; Gheorghe, Alina ; Díaz, Ligia Esperanza ; Marcos, Ascensión ; Fuente del Rey, Mónica de la | Springer Link | 2017-02-23Purpose: Obesity is associated with impaired immune defences and chronic low levels of inflammation and oxidation. In addition, this condition may lead to premature aging. The aim of the study was to evaluate the effects of a nutritional supplem[...]texto impreso
Hunsche, Caroline ; Martínez de Toda Cabeza, Irene ; Fuente del Rey, Mónica de la | Elsevier | 2019-05The aim of the present study was to investigate whether the late onset of diet-induced obesity (DIO) in middle-aged mice affected behavioral, immunological and oxidative stress parameters as well as life span of male and female mice. Also, it wa[...]texto impreso
Hunsche, Caroline ; Hernández, Oskarina ; Fuente del Rey, Mónica de la | The Gerontological Society of America | 2016Obesity and aging share an impaired immune system and oxidative and inflammatory stress. Therefore, the hypothesis of obesity as a possible model of premature immunosenescence has been proposed. In this study, we investigated whether adult obese[...]texto impreso
The homeostatic systems, such as the nervous and immune systems, show deterioration in aging as a consequence of the agerelated oxidative-infammatory stress establishment. The supplementation with fermented milk containing probiotic bacteria cou[...]texto impreso
En el envejecimiento tiene lugar un deterioro funcional progresivo de todos los sistemas fisiológicos del organismo, especialmente de los reguladores, el sistema nervioso, el endocrino y el inmunitario, lo que conlleva la pérdida de homeostasis [...]texto impreso
Oxidative stress and immunosenescence in spleen of obese mice can be reversed by 2-hydroxyoleic acid
Gheorghe, Alina ; Pérez de Heredia, Fátima ; Hunsche, Caroline ; Redondo, Noemí ; Díaz, Ligia Esperanza ; Hernández, Oskarina ; Marcos, Ascensión ; Fuente del Rey, Mónica de la | The Physiological Society | 2017-05-01New Findings: What is the central question of this study? Evidence is growing for the link between obesity, immune dysfunction and oxidative stress, but it is still not known how the properties and functions of the spleen and splenic leucocytes [...]texto impreso
Hunsche, Caroline ; Martínez de Toda Cabeza, Irene ; Hernández, Oskarina ; Jiménez, Beatriz ; Díaz, Ligia Esperanza ; Marcos, Ascensión ; Fuente del Rey, Mónica de la | Taylor & Francis | 2020-08-04Obesity and its related diseases have been associated with oxidative stress. Thus, the search for nutritional strategies to ameliorate oxidative stress in obese individuals seems important. We hypothesized that the supplementation with monounsat[...]
