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Martínez de Toda Cabeza, Irene ; Miguélez, Lara ; Vida, Carmen ; Carro, Eva ; Fuente del Rey, Mónica de la | IOS Press | 2019-09-03Oxidative stress plays an essential and early role in the pathophysiology of Alzheimer’s disease (AD). Alterations in the redox state in AD and in mild cognitive impairment (MCI) patients appear in the brain and at peripheral level. Given that i[...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; Sanz San Miguel, Luis ; Fuente del Rey, Mónica de la | Hindawi | 2019-06-02According to the oxidative-inflammatory theory of aging, there is a link between the function, the oxidative-inflammatory stress state of immune cells, and longevity. However, it is unknown which immune cell parameters can predict lifespan and i[...]texto impreso
Martínez de Toda Cabeza, Irene ; Miguélez, Lara ; Siboni, León ; Vida, Carmen ; Fuente del Rey, Mónica de la | Springer | 2019-08-08Chronic stress situations lead to an impairment of immune response and higher oxidative and inflammatory stress, which are important underlying mechanisms of the ageing process. However, given that the physiological stress response depends on th[...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; Ortega, Eduardo ; Fuente del Rey, Mónica de la | Elsevier | 2016-11Under stressful conditions, the expression of the chaperone Hsp70 is induced, which acts as a cellular defense mechanism. The impairment in this induction has been related to aging, whereas an increased expression has been related to longevity. [...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; García-Salmones, Marta ; Alonso-Fernández, Patricia ; Fuente del Rey, Mónica de la | Oxford University Press | 2019-10-20Several parameters of immune function, oxidative, and inflammatory stresses have been proposed as markers of health and predictors of longevity and mortality. However, it is unknown if any of these parameters can be used as predictors of surviva[...]texto impreso
Martínez de Toda Cabeza, Irene ; Maté, Ianire ; Vida, Carmen ; Cruces, Julia ; Fuente del Rey, Mónica de la | Aging | 2016Chronological age is not a good indicator of how each individual ages and thus how to maintain good health. Due to the long lifespan in humans and the consequent difficulty of carrying out longitudinal studies, finding valid biomarkers of the bi[...]texto impreso
Hunsche, Caroline ; Martínez de Toda Cabeza, Irene ; Fuente del Rey, Mónica de la | Elsevier | 2019-05The aim of the present study was to investigate whether the late onset of diet-induced obesity (DIO) in middle-aged mice affected behavioral, immunological and oxidative stress parameters as well as life span of male and female mice. Also, it wa[...]texto impreso
Vida, Carmen ; Martínez de Toda Cabeza, Irene ; Garrido Tarrio, Antonio ; Caro, Eva ; Molina, José Antonio ; Fuente del Rey, Mónica de la | Frontiers Media | 2018-01Since aging is considered the most risk factor for sporadic Alzheimer’s Disease (AD), the age-related impairment of the immune system (immunosenescence), based on a chronic oxidative-inflammatory stress situation, could play a key role in the de[...]texto impreso
El envejecimiento puede definirse como un proceso universal en el que se produce toda una serie de cambios biológicos, y que se caracteriza por una disminución progresiva y generalizada de la función del organismo y por una menor capacidad para [...]texto impreso
Ardura, Juan A. ; Portal Núñez, Sergio ; Castelbón Calvo, Irantzu ; Martínez de Toda Cabeza, Irene ; Fuente del Rey, Mónica de la ; Esbrit, Pedro | Wiley Online Library | 2017Oxidative damage is an important contributor to the morphological and functional changes in osteoporotic bone. Aging increases the levels of reactive oxygen species (ROS) that cause oxidative stress and induce osteoblast apoptosis. ROS modify se[...]texto impreso
Martínez de Toda Cabeza, Irene ; Vida, Carmen ; Garrido Tarrio, Antonio ; Fuente del Rey, Mónica de la | Oxford University Press | 2019-02-11Oxidative stress has been reported to increase with aging and although several agerelated changes in redox parameters have been described, none of them have been verified as markers of the rate of aging and lifespan. Therefore, antioxidant (cata[...]texto impreso
Vida, Carmen ; Martínez de Toda Cabeza, Irene ; Cruces, Julia ; Garrido Tarrio, Antonio ; González Sánchez, Mónica ; Fuente del Rey, Mónica de la | Elsevier | 2017The age-related changes in the immune functions (immunosenescence) may be mediated by an increase of oxidative stress and damage affecting leukocytes. Although the “oxidation-inflammation” theory of aging proposes that phagocytes are the main im[...]texto impreso
The heat-shock protein 70 (HSPA1A or Hsp70) acts as a cellular defense mechanism its expression being induced under stressful conditions. Aging has been related to an impairment in this induction. However, an extended longevity has been associat[...]texto impreso
Hunsche, Caroline ; Martínez de Toda Cabeza, Irene ; Hernández, Oskarina ; Jiménez, Beatriz ; Díaz, Ligia Esperanza ; Marcos, Ascensión ; Fuente del Rey, Mónica de la | Taylor & Francis | 2020-08-04Obesity and its related diseases have been associated with oxidative stress. Thus, the search for nutritional strategies to ameliorate oxidative stress in obese individuals seems important. We hypothesized that the supplementation with monounsat[...]texto impreso
Díaz del Cerro, Estefanía ; Vida, Carmen ; Martínez de Toda Cabeza, Irene ; Félix, Judith ; Fuente del Rey, Mónica de la | BMC | 2020-11-23Background: The immune system, as a homeostatic system, is an excellent marker of health and has also been proposed as an indicator of the rate of aging. The base of the age-related changes in the immune system, “immunosenescence”, is oxidative-[...]
