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Yang, Hailin ; Kim, Sung-Kwon ; Kim, Mikyung ; Reche, Pedro A ; Morehead, Tiara J ; Damon, Inger K ; Welsh, Raymond M ; Reinherz, Ellis L | American Society for Clinical Investigation | 2005The EGF-like domain of smallpox growth factor (SPGF) targets human ErbB-1, inducing tyrosine phosphorylation of certain host cellular substrates via activation of the receptor's kinase domain and thereby facilitating viral replication. Given the[...]texto impreso
Kim, Mikyung ; Yang, Hailin ; Kim, Sung-Kwon ; Reche, Pedro A ; Tirabassi, Rebecca S ; Hussey, Rebecca E ; Chishti, Yasmin ; Rheinwald, James G ; Morehead, Tiara J ; Zech, Tobias ; Damon, Inger K ; Welsh, Raymond M ; Reinherz, Ellis L | American Society for Biochemistry and Molecular Biology | 2004Variola, the causative agent of smallpox, is a highly infectious double-stranded DNA virus of the orthopox genus that replicates within the cytoplasm of infected cells. For unknown reasons prominent skin manifestations, including "pox," mark the[...]
