Información del autor
Autor Reche, Pedro A |
Documentos disponibles escritos por este autor (43)
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The transport of peptides to the endoplasmic reticulum by the transporter associated with antigen processing (TAP) is a necessary step towards determining CD8 T cell epitopes. In this work, we have studied the predictive performance of support v[...]![]()
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Bhasin, Manoj ; Reinherz, Ellis L ; Reche, Pedro A | 2006Histones are DNA-binding proteins found in the chromatin of all eukaryotic cells. They are highly conserved and can be grouped into five major classes: H1/H5, H2A, H2B, H3, and H4. Two copies of H2A, H2B, H3, and H4 bind to about 160 base pairs [...]![]()
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Martínez Naves, Eduardo ; Lafuente Duarte, Esther ; Reche, Pedro A | Federation of European Biochemical Societies | 2011Functional characterization of proteins belonging to the MHC I superfamily involves knowing their cognate ligands, which can be peptides, lipids or none. However, the experimental identification of these ligands is not an easy task and generally[...]![]()
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Reductive acetylation of the lipoyl domain (E2plip) of the dihydrolipoyl acetyltransferase component of the pyruvate dehydrogenase multienzyme complex of Escherichia coli is catalysed specifically by its partner pyruvate decarboxylase (E1p), and[...]![]()
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In this report,we present 15 patients with histological and immunopathologically proven pemphigus vulgaris (PV). After a mean of 80 months since the onset of disease, when evaluated serologically, they had antibodies typical of PV and pemphigoid[...]![]()
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Biotin-dependent enzymes contain a biotinyl-lysine residue in a conserved sequence motif, MKM, located in a surface hairpin turn in one of the two beta-sheets that make up the domain. A sub-gene encoding the 82-residue C-terminal biotinyl domain[...]![]()
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Major histocompatibility complex class I (MHCI) and class II (MHCII) molecules display peptides on antigen-presenting cell surfaces for subsequent T-cell recognition. Within the human population, allelic variation among the classical MHCI and II[...]![]()
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The lipoyl domains of the dihydrolipoyl acyltransferase (E2p, E2o) components of the pyruvate and 2-oxoglutarate dehydrogenase multienzyme complexes are specifically recognised by their cognate 2-oxo acid decarboxylase (E1p, E1o). A prominent su[...]![]()
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The post-translational attachment of biotin and lipoic acid to specific lysine residues displayed in protruding beta-turns in homologous biotinyl and lipoyl domains of their parent enzymes is catalysed by two different ligases. We have expressed[...]![]()
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Glowacki, Gustavo ; Braren, Rickmer ; Firner, Kathrin ; Nissen, Marion ; Kühl, Maren ; Reche, Pedro A ; Bazan, Fernando ; Cetkovic-Cvrlje, Marina ; Leiter, Edward ; Haag, Friedrich ; Koch-Nolte, Friedrich | 2002ADP-ribosyltransferases including toxins secreted by Vibrio cholera, Pseudomonas aerurginosa, and other pathogenic bacteria inactivate the function of human target proteins by attaching ADP-ribose onto a critical amino acid residue. Cross-specie[...]![]()
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García Fuentes, Luis ; Reche, Pedro A ; López Mayorga, O ; Santi, D V ; González-Pacanowska, D. ; Barón, C | Wiley InterScience | 1995The binding of 5-fluoro-2'-deoxyuridine 5'-monophosphate (FdUMP) to Lactobacillus casei recombinant thymidylate synthase has been studied by isothermal titration microcalorimetry at pH 7.1 over the temperature range 16-35 degrees C. Calorimetric[...]![]()
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Sheikh, Qamar M ; Gatherer, Derek ; Reche, Pedro A ; Flower, Darren R | Oxford University Pres | 2016-07Motivation: Influenza A viral heterogeneity remains a significant threat due to unpredictable antigenic drift in seasonal influenza and antigenic shifts caused by the emergence of novel subtypes. Annual review of multivalent influenza vaccines t[...]