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ADP-ribosyltransferases (ADPRTs) form an interesting class of enzymes with well-established roles as potent bacterial toxins and metabolic regulators. ADPRTs catalyze the transfer of the ADP-ribose moiety from NAD(+) onto specific substrates inc[...]texto impreso
Yang, Hailin ; Kim, Sung-Kwon ; Kim, Mikyung ; Reche, Pedro A ; Morehead, Tiara J ; Damon, Inger K ; Welsh, Raymond M ; Reinherz, Ellis L | American Society for Clinical Investigation | 2005The EGF-like domain of smallpox growth factor (SPGF) targets human ErbB-1, inducing tyrosine phosphorylation of certain host cellular substrates via activation of the receptor's kinase domain and thereby facilitating viral replication. Given the[...]texto impreso
Kim, Mikyung ; Yang, Hailin ; Kim, Sung-Kwon ; Reche, Pedro A ; Tirabassi, Rebecca S ; Hussey, Rebecca E ; Chishti, Yasmin ; Rheinwald, James G ; Morehead, Tiara J ; Zech, Tobias ; Damon, Inger K ; Welsh, Raymond M ; Reinherz, Ellis L | American Society for Biochemistry and Molecular Biology | 2004Variola, the causative agent of smallpox, is a highly infectious double-stranded DNA virus of the orthopox genus that replicates within the cytoplasm of infected cells. For unknown reasons prominent skin manifestations, including "pox," mark the[...]texto impreso
Reche, Pedro A ; Arrebola, R ; Olmo, A ; Santi, D V ; González-Pacanowska, D. ; Ruiz Pérez, Luis Miguel | Elsevier | 1994We have cloned, sequenced and expressed the Trypanosoma cruzi gene encoding the bifunctional protein dihydrofolate reductase-thymidylate synthase (DHFR-TS). The strategy followed for the isolation of positive clones from a genomic library was ba[...]texto impreso
Proteasomes play a central role in the major histocompatibility class I (MHCI) antigen processing pathway. They conduct the proteolytic degradation of proteins in the cytosol, generating the C-terminus of CD8 T cell epitopes and MHCI-peptide lig[...]texto impreso
Identification of peptides that can bind to major histocompatibility complex (MHC) molecules is important for anticipation of T-cell epitopes and for the design of epitope-based vaccines. Population coverage of epitope vaccines is, however, comp[...]texto impreso
Moody, A M ; Chui, D ; Reche, Pedro A ; Priatel, J J ; Marth, J D ; Reinherz, Ellis L | 2001The functional consequences of glycan structural changes associated with cellular differentiation are ill defined. Herein, we investigate the role of glycan adducts to the O-glycosylated polypeptide stalk tethering the CD8alphabeta coreceptor to[...]texto impreso
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Reche, Pedro A ; Keskin, Derin B ; Hussey, Rebecca E ; Ancuta, Petronela ; Gabuzda, Dana ; Reinherz, Ellis L | BioMed Central | 2006Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural constraints that ma[...]texto impreso
We introduced previously an on-line resource, RANKPEP that uses position specific scoring matrices (PSSMs) or profiles for the prediction of peptide-MHC class I (MHCI) binding as a basis for CD8 T-cell epitope identification. Here, using PSSMs t[...]texto impreso
Reche, Pedro A ; Zhang, Hong ; Glutting, John-Paul ; Reinherz, Ellis L | Oxford University Press | 2005EPIMHC is a relational database of MHC-binding peptides and T cell epitopes that are observed in real proteins. Currently, the database contains 4867 distinct peptide sequences from various sources, including 84 tumor-associated antigens. The EP[...]texto impreso
Reche, Pedro A ; Arrebola, R ; Santi, D V ; González-Pacanowska, D. ; Ruiz Pérez, Luis Miguel | Elsevier | 1995We have cloned and expressed in Escherichia coli a 702-base pair gene coding for the dihydrofolate reductase (DHFR) domain of the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Trypanosoma cruzi. The DHFR domain was pur[...]texto impreso
Zhong, Weimin ; Reche, Pedro A ; Lai, Char-Chang ; Reinhold, Bruce ; Reinherz, Ellis L | American Society for Biochemistry and Molecular Biology | 2003A genome-wide search using major histocompatibility complex (MHC) class I binding and proteosome cleavage site algorithms identified 101 influenza A PR8 virus-derived peptides as potential epitopes for CD8+ T cell recognition in the H-2b mouse. [...]texto impreso
The lipoyl domains of 2-oxo acid dehydrogenase multienzyme complexes and the biotinyl domains of biotin-dependent enzymes have homologous structures, but the target lysine residue in each domain is correctly selected for posttranslational modifi[...]texto impreso
Soumelis, Vassili ; Reche, Pedro A ; Kanzler, Holger ; Yuan, Wei ; Edward, Gina ; Homey, Bernhart ; Gilliet, Michel ; Ho, Steve ; Antonenko, Svetlana ; Lauerma, Annti ; Smith, Kathleen ; Gorman, Daniel ; Zurawski, Sandra M. ; Abrams, Jon ; Menon, Satish ; McClanahan, Terri ; Waal-Malefyt, Rene de ; Bazan, Fernando ; Kastelein, Robert A. ; Liu, Yong-Jun | Nature Publishing Group | 2002Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T(H)2)-type allergic inflammation is not known. We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c(+) dendritic cells [...]
