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Autor Reche, Pedro A |
Documentos disponibles escritos por este autor (43)
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ADP-ribosyltransferases (ADPRTs) form an interesting class of enzymes with well-established roles as potent bacterial toxins and metabolic regulators. ADPRTs catalyze the transfer of the ADP-ribose moiety from NAD(+) onto specific substrates inc[...]![]()
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Yang, Hailin ; Kim, Sung-Kwon ; Kim, Mikyung ; Reche, Pedro A ; Morehead, Tiara J ; Damon, Inger K ; Welsh, Raymond M ; Reinherz, Ellis L | American Society for Clinical Investigation | 2005The EGF-like domain of smallpox growth factor (SPGF) targets human ErbB-1, inducing tyrosine phosphorylation of certain host cellular substrates via activation of the receptor's kinase domain and thereby facilitating viral replication. Given the[...]![]()
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Kim, Mikyung ; Yang, Hailin ; Kim, Sung-Kwon ; Reche, Pedro A ; Tirabassi, Rebecca S ; Hussey, Rebecca E ; Chishti, Yasmin ; Rheinwald, James G ; Morehead, Tiara J ; Zech, Tobias ; Damon, Inger K ; Welsh, Raymond M ; Reinherz, Ellis L | American Society for Biochemistry and Molecular Biology | 2004Variola, the causative agent of smallpox, is a highly infectious double-stranded DNA virus of the orthopox genus that replicates within the cytoplasm of infected cells. For unknown reasons prominent skin manifestations, including "pox," mark the[...]![]()
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Reche, Pedro A ; Arrebola, R ; Olmo, A ; Santi, D V ; González-Pacanowska, D. ; Ruiz Pérez, Luis Miguel | Elsevier | 1994We have cloned, sequenced and expressed the Trypanosoma cruzi gene encoding the bifunctional protein dihydrofolate reductase-thymidylate synthase (DHFR-TS). The strategy followed for the isolation of positive clones from a genomic library was ba[...]![]()
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Proteasomes play a central role in the major histocompatibility class I (MHCI) antigen processing pathway. They conduct the proteolytic degradation of proteins in the cytosol, generating the C-terminus of CD8 T cell epitopes and MHCI-peptide lig[...]![]()
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Identification of peptides that can bind to major histocompatibility complex (MHC) molecules is important for anticipation of T-cell epitopes and for the design of epitope-based vaccines. Population coverage of epitope vaccines is, however, comp[...]![]()
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Moody, A M ; Chui, D ; Reche, Pedro A ; Priatel, J J ; Marth, J D ; Reinherz, Ellis L | 2001The functional consequences of glycan structural changes associated with cellular differentiation are ill defined. Herein, we investigate the role of glycan adducts to the O-glycosylated polypeptide stalk tethering the CD8alphabeta coreceptor to[...]![]()
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Reche, Pedro A ; Keskin, Derin B ; Hussey, Rebecca E ; Ancuta, Petronela ; Gabuzda, Dana ; Reinherz, Ellis L | BioMed Central | 2006Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural constraints that ma[...]![]()
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We introduced previously an on-line resource, RANKPEP that uses position specific scoring matrices (PSSMs) or profiles for the prediction of peptide-MHC class I (MHCI) binding as a basis for CD8 T-cell epitope identification. Here, using PSSMs t[...]![]()
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Reche, Pedro A ; Zhang, Hong ; Glutting, John-Paul ; Reinherz, Ellis L | Oxford University Press | 2005EPIMHC is a relational database of MHC-binding peptides and T cell epitopes that are observed in real proteins. Currently, the database contains 4867 distinct peptide sequences from various sources, including 84 tumor-associated antigens. The EP[...]![]()
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Reche, Pedro A ; Arrebola, R ; Santi, D V ; González-Pacanowska, D. ; Ruiz Pérez, Luis Miguel | Elsevier | 1995We have cloned and expressed in Escherichia coli a 702-base pair gene coding for the dihydrofolate reductase (DHFR) domain of the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) from Trypanosoma cruzi. The DHFR domain was pur[...]![]()
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Zhong, Weimin ; Reche, Pedro A ; Lai, Char-Chang ; Reinhold, Bruce ; Reinherz, Ellis L | American Society for Biochemistry and Molecular Biology | 2003A genome-wide search using major histocompatibility complex (MHC) class I binding and proteosome cleavage site algorithms identified 101 influenza A PR8 virus-derived peptides as potential epitopes for CD8+ T cell recognition in the H-2b mouse. [...]![]()
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The lipoyl domains of 2-oxo acid dehydrogenase multienzyme complexes and the biotinyl domains of biotin-dependent enzymes have homologous structures, but the target lysine residue in each domain is correctly selected for posttranslational modifi[...]![]()
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Soumelis, Vassili ; Reche, Pedro A ; Kanzler, Holger ; Yuan, Wei ; Edward, Gina ; Homey, Bernhart ; Gilliet, Michel ; Ho, Steve ; Antonenko, Svetlana ; Lauerma, Annti ; Smith, Kathleen ; Gorman, Daniel ; Zurawski, Sandra M. ; Abrams, Jon ; Menon, Satish ; McClanahan, Terri ; Waal-Malefyt, Rene de ; Bazan, Fernando ; Kastelein, Robert A. ; Liu, Yong-Jun | Nature Publishing Group | 2002Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T(H)2)-type allergic inflammation is not known. We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c(+) dendritic cells [...]![]()
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Reche, Pedro A ; Soumelis, Vassili ; Gorman, D M ; Clifford, T ; Liu, MR ; Travis, M ; Zurawski, Sandra M. ; Johnston, J ; Liu, Yong-Jun ; Spits, H ; Waal-Malefyt, Rene de ; Kastelein, Robert A. ; Bazan, Fernando | The American Association of Immunologists | 2001The sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal [...]![]()
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Otto, Helge ; Reche, Pedro A ; Bazan, Fernando ; Dittmar, Katharina ; Haag, Friedrich ; Koch-Nolte, Friedrich | 2005BACKGROUND: ADP-ribosylation is an enzyme-catalyzed posttranslational protein modification in which mono(ADP-ribosyl)transferases (mARTs) and poly(ADP-ribosyl)transferases (pARTs) transfer the ADP-ribose moiety from NAD onto specific amino acid [...]![]()
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Immunoinformatics is an emerging new field that benefits from computational analyses and tools that facilitate the understanding of the immune system. A large number of immunoinformatics resources such as immune-related databases and analysis so[...]![]()
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Diez Rivero, Carmen ; García Boronat, María ; Reche, Pedro A | Biomedical Informatics Publishing Group | 2008Immunoinformatics is an emerging new field that benefits from computational analyses and tools that facilitate the understanding of the immune system. A large number of immunoinformatics resources such as immune-related databases and analysis so[...]![]()
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Arrebola, R ; Olmo, A ; Reche, Pedro A ; Garvey, Edward P. ; Santi, D V ; Ruiz Pérez, Luis Miguel ; González-Pacanowska, D. | American Society for Biochemistry and Molecular Biology | 1994-04-08The MTX-resistant Leishmania major promastigote cell line D7BR1000 displays extrachromosomal amplified R-region DNA, which contains the gene for dihydrofolate reductase-thymidylate synthase (DHFR-TS) (Garvey, E. P., and Santi, D. V. (1986) Scien[...]![]()
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Arrebola, R ; Olmo, A ; Reche, Pedro A ; Garvey, Edward P. ; Santi, D V ; Ruiz Pérez, Luis Miguel ; González-Pacanowska, D. | 1994The MTX-resistant Leishmania major promastigote cell line D7BR1000 displays extrachromosomal amplified R-region DNA, which contains the gene for dihydrofolate reductase-thymidylate synthase (DHFR-TS) (Garvey, E. P., and Santi, D. V. (1986) Scien[...]![]()
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Reche, Pedro A | 2000Biotin and lipoic acid moieties are the covalently attached coenzyme cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions. Attachment of these moieties to the biotinyl- and lipoyl-dependent enzymes is post-t[...]![]()
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Fiorini, Emma ; Reche, Pedro A | 2002Negative selection eliminates thymocytes bearing autoreactive T cell receptors (TCR) via an apoptotic mechanism. We have cloned an inhibitor of NF-kappa B, I kappa BNS, which is rapidly expressed upon TCR-triggered but not dexamethasone- or gamm[...]![]()
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Fridkis-Hareli, Masha ; Reche, Pedro A ; Reinherz, Ellis L | 2004During development, thymocytes carrying TCRs mediating low-affinity interactions with MHC-bound self-peptides are positively selected for export into the mature peripheral T lymphocyte pool. Thus, exogenous administration of certain altered pept[...]![]()
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Reche, Pedro A ; Reinherz, Ellis L | 2005Prediction of peptide binding to major histocompatibility complex (MHC) molecules is a basis for anticipating T-cell epitopes, as well as epitope discovery-driven vaccine development. In the human, MHC molecules are known as human leukocyte anti[...]