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Autor Reche, Pedro A |
Documentos disponibles escritos por este autor (43)
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Reche, Pedro A ; Soumelis, Vassili ; Gorman, D M ; Clifford, T ; Liu, MR ; Travis, M ; Zurawski, Sandra M. ; Johnston, J ; Liu, Yong-Jun ; Spits, H ; Waal-Malefyt, Rene de ; Kastelein, Robert A. ; Bazan, Fernando | The American Association of Immunologists | 2001The sequence of a novel hemopoietic cytokine was discovered in a computational screen of genomic databases, and its homology to mouse thymic stromal lymphopoietin (TSLP) suggests that it is the human orthologue. Human TSLP is proposed to signal [...]texto impreso
Otto, Helge ; Reche, Pedro A ; Bazan, Fernando ; Dittmar, Katharina ; Haag, Friedrich ; Koch-Nolte, Friedrich | 2005BACKGROUND: ADP-ribosylation is an enzyme-catalyzed posttranslational protein modification in which mono(ADP-ribosyl)transferases (mARTs) and poly(ADP-ribosyl)transferases (pARTs) transfer the ADP-ribose moiety from NAD onto specific amino acid [...]texto impreso
Immunoinformatics is an emerging new field that benefits from computational analyses and tools that facilitate the understanding of the immune system. A large number of immunoinformatics resources such as immune-related databases and analysis so[...]texto impreso
Diez Rivero, Carmen ; García Boronat, María ; Reche, Pedro A | Biomedical Informatics Publishing Group | 2008Immunoinformatics is an emerging new field that benefits from computational analyses and tools that facilitate the understanding of the immune system. A large number of immunoinformatics resources such as immune-related databases and analysis so[...]texto impreso
Arrebola, R ; Olmo, A ; Reche, Pedro A ; Garvey, Edward P. ; Santi, D V ; Ruiz Pérez, Luis Miguel ; González-Pacanowska, D. | American Society for Biochemistry and Molecular Biology | 1994-04-08The MTX-resistant Leishmania major promastigote cell line D7BR1000 displays extrachromosomal amplified R-region DNA, which contains the gene for dihydrofolate reductase-thymidylate synthase (DHFR-TS) (Garvey, E. P., and Santi, D. V. (1986) Scien[...]texto impreso
Arrebola, R ; Olmo, A ; Reche, Pedro A ; Garvey, Edward P. ; Santi, D V ; Ruiz Pérez, Luis Miguel ; González-Pacanowska, D. | 1994The MTX-resistant Leishmania major promastigote cell line D7BR1000 displays extrachromosomal amplified R-region DNA, which contains the gene for dihydrofolate reductase-thymidylate synthase (DHFR-TS) (Garvey, E. P., and Santi, D. V. (1986) Scien[...]texto impreso
Reche, Pedro A | 2000Biotin and lipoic acid moieties are the covalently attached coenzyme cofactors of several multicomponent enzyme complexes that catalyze key metabolic reactions. Attachment of these moieties to the biotinyl- and lipoyl-dependent enzymes is post-t[...]texto impreso
Fiorini, Emma ; Reche, Pedro A | 2002Negative selection eliminates thymocytes bearing autoreactive T cell receptors (TCR) via an apoptotic mechanism. We have cloned an inhibitor of NF-kappa B, I kappa BNS, which is rapidly expressed upon TCR-triggered but not dexamethasone- or gamm[...]texto impreso
Fridkis-Hareli, Masha ; Reche, Pedro A ; Reinherz, Ellis L | 2004During development, thymocytes carrying TCRs mediating low-affinity interactions with MHC-bound self-peptides are positively selected for export into the mature peripheral T lymphocyte pool. Thus, exogenous administration of certain altered pept[...]texto impreso
Reche, Pedro A ; Reinherz, Ellis L | 2005Prediction of peptide binding to major histocompatibility complex (MHC) molecules is a basis for anticipating T-cell epitopes, as well as epitope discovery-driven vaccine development. In the human, MHC molecules are known as human leukocyte anti[...]texto impreso
DNA methylation plays a key role in the regulation of gene expression. The most common type of DNA modification consists of the methylation of cytosine in the CpG dinucleotide. At the present time, there is no method available for the prediction[...]texto impreso
Peptides that bind to a given major histocompatibility complex (MHC) molecule share sequence similarity. Therefore, a position specific scoring matrix (PSSM) or profile derived from a set of peptides known to bind to a specific MHC molecule woul[...]texto impreso
T cell immune responses are driven by the recognition of peptide antigens (T cell epitopes) that are bound to major histocompatibility complex (MHC) molecules. T cell epitope immunogenicity is thus contingent on several events, including appropr[...]texto impreso
Reche, Pedro A ; Reinherz, Ellis L | 2007Prediction of peptide binding to major histocompatibility complex (MHC) molecules is a basis for anticipating T-cell epitopes. Peptides that bind to a given MHC molecule are related by sequence similarity. Therefore, a position-specific scoring [...]texto impreso
García Boronat, María ; Díez Rivero, Carmen M. ; Reinherz, Ellis L ; Reche, Pedro A | Oxford University Press | 2008We have developed PVS (Protein Variability Server), a web-based tool that uses several variability metrics to compute the absolute site variability in multiple protein-sequence alignments (MSAs). The variability is then assigned to a user-select[...]