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Villanueva Romero, Raúl ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; González Álvaro, Isidoro ; Rodríguez Frade, José Miguel ; Mellado, Mario ; Martínez, Carmen ; Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina | Nature Research | 2019-05-14Vasoactive Intestinal Peptide (VIP) is an important immunomodulator of CD4+ cells in normal and pathological conditions, which exerts its anti-infammatory and immunomodulatory actions through VPAC receptors, VPAC1 and VPAC2. Only a decrease in t[...]texto impreso
Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina ; Carrión Caballo, Mar ; Pérez García, Selene ; Villanueva Romero, Raúl ; González Álvaro, Isidoro ; Gutiérrez Cañas, Irene ; Lamana, Amalia ; Martínez, Carmen | Frontiers Media | 2019-10-22The axis comprised by the Vasoactive Intestinal Peptide (VIP) and its G protein-coupled receptors (GPCRs), VPAC1, and VPAC2, belong to the B1 family and signal through Gs or Gq proteins. VPAC receptors seem to preferentially interact with Gs in [...]texto impreso
Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; Juarranz Moratilla, Yasmina ; Lamana Domínguez, Amalia ; López Redondo, Jesús María ; Morona Arribas, Ruth ; Muñoz Céspedes, Alberto ; Ortega Moreno, Álvaro Dario ; Pérez García, Selene ; Pérez Gomáriz, Rosa María | 2020-07-01La clase invertida o clase al revés, también conocida por el anglicismo flipped classroom, es una metodología docente en la que, como su nombre indica, se invierten los procesos que clásicamente tienen lugar dentro y fuera del aula. De manera qu[...]texto impreso
Martínez, Carmen ; Juarranz Moratilla, Yasmina ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Villanueva Romero, Raúl ; Castro Moreno, David ; Lamana, Amalia ; Mellado, Mario ; González Álvaro, Isidoro ; Gomáriz, Rosa P. | MDPI | 2019-12-20The neuroendocrine and immune systems are coordinated to maintain the homeostasis of the organism, generating bidirectional communication through shared mediators and receptors. Vasoactive intestinal peptide (VIP) is the paradigm of an endogenou[...]texto impreso
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Morona Arribas, Ruth ; González Gallegos, Agustín ; Gutiérrez Cañas, Irene ; García-Ceca Hernández, José Javier ; López Redondo, Jesús María ; Alfaro Sánchez, David ; Muñiz Hernando, Enriqueta ; Carrión Caballo, Mar ; Moreno García, Nerea ; Pérez García, Selene ; Pérez Gomáriz, Rosa María | 2018-05-31Histoteca digital para que los alumnos puedan consultar un material gráfico actualizado y concreto, similar a lo que observan en el microscopio cuando realizan sus prácticas de Organografía de la asignatura de “Organografía microscópica” del Gra[...]texto impreso
Pérez García, Selene ; Carrión Caballo, Mar ; Gutiérrez-Cañas, Irene ; Villanueva-Romero, Raúl ; Castro Moreno, David ; Martínez, Carmen ; González-Álvaro, Isidoro ; Blanco, Francisco J. ; Juarranz Moratilla, Yasmina ; Gomáriz, Rosa P. | MDPI | 2019-12-22The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical[...]texto impreso
Carrión Caballo, Mar ; Frommer, Klaus W. ; Pérez García, Selene ; Müller-Ladner, Ulf ; Gomáriz, Rosa P. ; Neumann, Elena | MDPI | 2019-08-22Rheumatic diseases encompass a diverse group of chronic disorders that commonly affect musculoskeletal structures. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common, leading to considerable functional limitations and irre[...]texto impreso
Villanueva Romero, Raúl ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Seoane Valiño, Iria V. ; Martínez, Carmen ; Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina | Hindawi | 2018Genetic background, epigenetic modifications, and environmental factors trigger autoimmune response in rheumatoid arthritis (RA). Several pathogenic infections have been related to the onset of RA and may cause an inadequate immunological tolera[...]texto impreso
Jimeno Lumeras, Rebeca Gema ; Pérez Gomáriz, Rosa Mª ; Garín, Marina ; Gutiérrez Cañas, Irene ; González Álvaro, Isidoro ; Carrión Caballo, Mar ; Galindo, María ; Leceta Martínez, Javier ; Juarranz Moratilla, Yasmina | Springer | 2015Our aim is to study the behavior of memory Th cells (Th17, Th17/1, and Th1 profiles) from early rheumatoid arthritis (eRA) patients after their in vitro activation/expansion to provide information about its contribution to RA chronicity. Moreove[...]texto impreso
Carrión Caballo, Mar ; Ramos-Levi, A. M. ; Valiño Seoane, Iria ; Martínez Hernández, R. ; Serrano-Somavilla, A. ; Castro Vázquez, David ; Juarranz Moratilla, Yasmina ; González Álvaro, I. ; Gomáriz, Rosa P. ; Marazuela, Mónica | Nature Research | 2020-08-03Vasoactive intestinal peptide (VIP) is a neuropeptide with potent immunoregulatory properties. Reduced serum VIP levels and alterations in VIP receptors/signaling on immune cells have been associated with diferent infammatory/autoimmune diseases[...]texto impreso
Jimeno Lumeras, Rebeca Gema ; Leceta Martínez, Javier ; Martínez, Carmen ; Gutiérrez-Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Garín, Marina ; Mellado, Mario ; Pérez Gomáriz, Rosa María ; Juarranz Moratilla, Yasmina | Springer | 2014-11The cytokine microenvironment modulates CD4 T cell differentiation causing the shift of naïve CD4 T cells into different cell subsets. This process is also regulated by modulators such as VIP, a neuropeptide with known immunomodulatory propertie[...]texto impreso
Pérez García, Selene ; Carrión Caballo, Mar ; Gutiérrez Cañas, Irene ; González Álvaro, Isidoro ; Pérez Gomáriz, Rosa María ; Juarranz Moratilla, Yasmina | John Willey | 2016-04ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family is known to play an important role in the pathogenesis of osteoarthritis (OA), working on aggrecan degradation or altering the integrity of extracellular matrix (ECM)[...]texto impreso
Carrión Caballo, Mar ; Pérez García, Selene ; Martínez, Carmen ; Juarranz Moratilla, Yasmina ; Estrada Capetillo, Lizbeth ; Puig-Kröger, Amaya ; Pérez Gomáriz, Rosa María ; Gutiérrez Cañas, Irene | 2016-12This study tested the hypothesis that vasoactive intestinal peptide (VIP) is able to modify the macrophage inflammatory profile, thus supporting its therapeutic role in autoimmune diseases. Macrophages are innate immune cells that display a vari[...]texto impreso
Pérez García, Selene ; Carrión Caballo, Mar ; Villanueva Romero, Raúl ; Hermida Gómez, Tamara ; Fernández Moreno, Mercedes ; Mellado, Mario ; Blanco, Francisco J. ; Juarranz Moratilla, Yasmina ; Gomáriz, Rosa P. | Wiley Open Acces | 2019Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the inhibition of metalloproteinases, might be because of their constitutive expres? sion in homeostasis, together with their network complexity. The knowledge o[...]
