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Villanueva Romero, Raúl ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; González Álvaro, Isidoro ; Rodríguez Frade, José Miguel ; Mellado, Mario ; Martínez, Carmen ; Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina | Nature Research | 2019-05-14Vasoactive Intestinal Peptide (VIP) is an important immunomodulator of CD4+ cells in normal and pathological conditions, which exerts its anti-infammatory and immunomodulatory actions through VPAC receptors, VPAC1 and VPAC2. Only a decrease in t[...]texto impreso
Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina ; Carrión Caballo, Mar ; Pérez García, Selene ; Villanueva Romero, Raúl ; González Álvaro, Isidoro ; Gutiérrez Cañas, Irene ; Lamana, Amalia ; Martínez, Carmen | Frontiers Media | 2019-10-22The axis comprised by the Vasoactive Intestinal Peptide (VIP) and its G protein-coupled receptors (GPCRs), VPAC1, and VPAC2, belong to the B1 family and signal through Gs or Gq proteins. VPAC receptors seem to preferentially interact with Gs in [...]texto impreso
Martínez, Carmen ; Juarranz Moratilla, Yasmina ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Villanueva Romero, Raúl ; Castro Moreno, David ; Lamana, Amalia ; Mellado, Mario ; González Álvaro, Isidoro ; Gomáriz, Rosa P. | MDPI | 2019-12-20The neuroendocrine and immune systems are coordinated to maintain the homeostasis of the organism, generating bidirectional communication through shared mediators and receptors. Vasoactive intestinal peptide (VIP) is the paradigm of an endogenou[...]texto impreso
Lamana, Amalia ; Villares, Ricardo ; Seoane Valiño, Iria V. ; Andrés, Nuria ; Lucas, Pilar ; Emery, Paul ; Vital, Edward M. ; Triguero-Martínez, Ana ; Márquez, Ana ; Ortiz, Ana M. ; Maxime, Robin ; Martínez, Carmen ; Martín, Javier ; Gomáriz, Rosa P. ; Ponchel, Frederique ; González-Álvaro, Isidoro ; Mellado, Mario | Frontiers Media | 2020-06-26Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by an autoimmune response in the joints and an exacerbation of cytokine responses. A minority of patients with RA experience spontaneous remission, but most will show mode[...]texto impreso
Pérez García, Selene ; Carrión Caballo, Mar ; Gutiérrez-Cañas, Irene ; Villanueva-Romero, Raúl ; Castro Moreno, David ; Martínez, Carmen ; González-Álvaro, Isidoro ; Blanco, Francisco J. ; Juarranz Moratilla, Yasmina ; Gomáriz, Rosa P. | MDPI | 2019-12-22The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical[...]texto impreso
Jimeno, Rebeca ; Leceta Martínez, Javier ; Garín, Marina ; Ortiz, Ana M. ; Mellado, Mario ; Rodríguez Frade, José Miguel ; Martínez, Carmen ; Pérez García, Selene ; Pérez Gomáriz, Rosa María ; Juarranz Moratilla, Yasmina | The Society for Leukocyte Biology. | 2015-08Several studies in humans indicate the implication of Th17 cells in RA. Therapies targeting their pathogenicity, as well as their plasticity to the Th17/1 phenotype, could ameliorate the progression of the pathology. The neuroendocrine environme[...]texto impreso
Villanueva Romero, Raúl ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Seoane Valiño, Iria V. ; Martínez, Carmen ; Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina | Hindawi | 2018Genetic background, epigenetic modifications, and environmental factors trigger autoimmune response in rheumatoid arthritis (RA). Several pathogenic infections have been related to the onset of RA and may cause an inadequate immunological tolera[...]texto impreso
Seoane Valiño, Iria V. ; Martínez, Carmen ; Garcia-Vicuña, Rosario ; Ortiz, Ana M. ; Juarranz Moratilla, Yasmina ; Talayero, Vanessa C. ; González-Álvaro, Isidoro ; Gomáriz, Rosa P. ; Lamana, Amalia | Nature Publishing Group | 2018-02-01We previously reported that early arthritis (EA) patients with low vasoactive intestinal peptide (VIP) serum levels demonstrate a worse clinical disease course. In this study, we analysed whether variants in the VIP gene correlated with its seru[...]texto impreso
Valiño Seoane, Iria ; Tomero, Eva ; Martínez, Carmen ; Garcia-Vicuña, Rosario ; Juarranz Moratilla, Yasmina ; Lamana, Amalia ; Ocón, Elena ; Ortiz, Ana M. ; Gómez-León, Nieves ; González-Álvaro, Isidoro ; Pérez-Gomáriz, Rosa | Springer | 2015-02Spondyloarthritis (SpA) is a family of inflammatory diseases sharing clinical, genetic, and radiological features. While crucial for tailoring early interventions, validated prognostic biomarkers are scarce in SpA. We analyze the correlation bet[...]texto impreso
Jimeno Lumeras, Rebeca Gema ; Leceta Martínez, Javier ; Martínez, Carmen ; Gutiérrez-Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Garín, Marina ; Mellado, Mario ; Pérez Gomáriz, Rosa María ; Juarranz Moratilla, Yasmina | Springer | 2014-11The cytokine microenvironment modulates CD4 T cell differentiation causing the shift of naïve CD4 T cells into different cell subsets. This process is also regulated by modulators such as VIP, a neuropeptide with known immunomodulatory propertie[...]texto impreso
Carrión Caballo, Mar ; Pérez García, Selene ; Martínez, Carmen ; Juarranz Moratilla, Yasmina ; Estrada Capetillo, Lizbeth ; Puig-Kröger, Amaya ; Pérez Gomáriz, Rosa María ; Gutiérrez Cañas, Irene | 2016-12This study tested the hypothesis that vasoactive intestinal peptide (VIP) is able to modify the macrophage inflammatory profile, thus supporting its therapeutic role in autoimmune diseases. Macrophages are innate immune cells that display a vari[...]
