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Villanueva Romero, Raúl ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; González Álvaro, Isidoro ; Rodríguez Frade, José Miguel ; Mellado, Mario ; Martínez, Carmen ; Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina | Nature Research | 2019-05-14Vasoactive Intestinal Peptide (VIP) is an important immunomodulator of CD4+ cells in normal and pathological conditions, which exerts its anti-infammatory and immunomodulatory actions through VPAC receptors, VPAC1 and VPAC2. Only a decrease in t[...]texto impreso
Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina ; Carrión Caballo, Mar ; Pérez García, Selene ; Villanueva Romero, Raúl ; González Álvaro, Isidoro ; Gutiérrez Cañas, Irene ; Lamana, Amalia ; Martínez, Carmen | Frontiers Media | 2019-10-22The axis comprised by the Vasoactive Intestinal Peptide (VIP) and its G protein-coupled receptors (GPCRs), VPAC1, and VPAC2, belong to the B1 family and signal through Gs or Gq proteins. VPAC receptors seem to preferentially interact with Gs in [...]texto impreso
González Álvaro, I. ; Ortiz, A. Mª. ; Valiño Seoane, Iria ; García Vicuña, Rosario ; Martínez, C. ; Gomáriz, Rosa P. | Bentham Science Publishers | 2015The heterogeneous nature of rheumatoid arthritis (RA) complicates early recognition and treatment. In recent years, a growing body of evidence has demonstrated that intervention during the window of opportunity can improve the response to treatm[...]texto impreso
Martínez, Carmen ; Juarranz Moratilla, Yasmina ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Villanueva Romero, Raúl ; Castro Moreno, David ; Lamana, Amalia ; Mellado, Mario ; González Álvaro, Isidoro ; Gomáriz, Rosa P. | MDPI | 2019-12-20The neuroendocrine and immune systems are coordinated to maintain the homeostasis of the organism, generating bidirectional communication through shared mediators and receptors. Vasoactive intestinal peptide (VIP) is the paradigm of an endogenou[...]texto impreso
Lamana, Amalia ; Villares, Ricardo ; Seoane Valiño, Iria V. ; Andrés, Nuria ; Lucas, Pilar ; Emery, Paul ; Vital, Edward M. ; Triguero-Martínez, Ana ; Márquez, Ana ; Ortiz, Ana M. ; Maxime, Robin ; Martínez, Carmen ; Martín, Javier ; Gomáriz, Rosa P. ; Ponchel, Frederique ; González-Álvaro, Isidoro ; Mellado, Mario | Frontiers Media | 2020-06-26Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by an autoimmune response in the joints and an exacerbation of cytokine responses. A minority of patients with RA experience spontaneous remission, but most will show mode[...]texto impreso
Villares, Ricardo ; Criado, Gabriel ; Juarranz Moratilla, Yasmina ; López Santalla, Mercedes ; García-Cuesta, Eva María ; Rodríguez Frade, José Miguel ; Leceta Martínez, Javier ; Lucas, Pilar ; Pablos, José L. ; Martínez-A., Carlos ; Garin, Marina I. ; Gomáriz, Rosa P. ; Mellado, Mario | Frontiers Media | 2018-05-25Evidence indicates an intimate connection between the neuroendocrine and the immune systems. A number of in vitro and in vivo studies have demonstrated growth hormone (GH) involvement in immune regulation. The GH receptor is expressed by several[...]texto impreso
Pérez García, Selene ; Carrión Caballo, Mar ; Gutiérrez-Cañas, Irene ; Villanueva-Romero, Raúl ; Castro Moreno, David ; Martínez, Carmen ; González-Álvaro, Isidoro ; Blanco, Francisco J. ; Juarranz Moratilla, Yasmina ; Gomáriz, Rosa P. | MDPI | 2019-12-22The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical[...]texto impreso
Carrión Caballo, Mar ; Frommer, Klaus W. ; Pérez García, Selene ; Müller-Ladner, Ulf ; Gomáriz, Rosa P. ; Neumann, Elena | MDPI | 2019-08-22Rheumatic diseases encompass a diverse group of chronic disorders that commonly affect musculoskeletal structures. Osteoarthritis (OA) and rheumatoid arthritis (RA) are the two most common, leading to considerable functional limitations and irre[...]texto impreso
Villanueva Romero, Raúl ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Seoane Valiño, Iria V. ; Martínez, Carmen ; Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina | Hindawi | 2018Genetic background, epigenetic modifications, and environmental factors trigger autoimmune response in rheumatoid arthritis (RA). Several pathogenic infections have been related to the onset of RA and may cause an inadequate immunological tolera[...]texto impreso
D’Agostino, Gianluca ; García-Cuesta, Eva María ; Gomáriz, Rosa P. ; Rodríguez-Frade, José Miguel ; Mellado, Mario | Elsevier | 2020-03-05The chemokines receptor family are membrane-expressed class A-specific seven-transmembrane receptors linked to G proteins. Through interaction with the corresponding ligands, the chemokines, they induce a wide variety of cellular responses inclu[...]texto impreso
Carrión Caballo, Mar ; Ramos-Levi, A. M. ; Valiño Seoane, Iria ; Martínez Hernández, R. ; Serrano-Somavilla, A. ; Castro Vázquez, David ; Juarranz Moratilla, Yasmina ; González Álvaro, I. ; Gomáriz, Rosa P. ; Marazuela, Mónica | Nature Research | 2020-08-03Vasoactive intestinal peptide (VIP) is a neuropeptide with potent immunoregulatory properties. Reduced serum VIP levels and alterations in VIP receptors/signaling on immune cells have been associated with diferent infammatory/autoimmune diseases[...]texto impreso
Seoane Valiño, Iria V. ; Martínez, Carmen ; Garcia-Vicuña, Rosario ; Ortiz, Ana M. ; Juarranz Moratilla, Yasmina ; Talayero, Vanessa C. ; González-Álvaro, Isidoro ; Gomáriz, Rosa P. ; Lamana, Amalia | Nature Publishing Group | 2018-02-01We previously reported that early arthritis (EA) patients with low vasoactive intestinal peptide (VIP) serum levels demonstrate a worse clinical disease course. In this study, we analysed whether variants in the VIP gene correlated with its seru[...]texto impreso
Pérez García, Selene ; Carrión Caballo, Mar ; Villanueva Romero, Raúl ; Hermida Gómez, Tamara ; Fernández Moreno, Mercedes ; Mellado, Mario ; Blanco, Francisco J. ; Juarranz Moratilla, Yasmina ; Gomáriz, Rosa P. | Wiley Open Acces | 2019Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the inhibition of metalloproteinases, might be because of their constitutive expres? sion in homeostasis, together with their network complexity. The knowledge o[...]
