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García-Segura, Luis Miguel ; Veiga, Sergio ; Sierra, Amanda ; Melcangi, Roberto C. ; Azcoitia Elías, Iñigo | Elsevier | 2003-09Estradiol, in addition to its participation in neuroendocrine regulation and sexual behavior, has neuroprotective properties. Different types of brain injury induce the expression of the enzyme aromatase in reactive astroglia. This enzyme cataly[...]texto impreso
Estradiol biosynthesis is catalyzed by the enzyme aromatase, the product of the CYP19A1 gene. Aromatase is expressed in the brain, where it is involved not only in the control of neuroendocrine events and reproduction, but also in the regulation[...]texto impreso
Azcoitia Elías, Iñigo ; García-Caceres, Cristina ; Lagunas, Natalia ; Calmarza-Font, Isabel ; Diz Chaves, Yolanda ; García Segura, Luis Miguel ; Vaquedano, Eva ; Frago, Laura M. ; Argente, Jesús ; Chowen, Julie A. | Elsevier | 2010-11Stress during pregnancy can impair biological and behavioral responses in the adult offspring and some of these effects are associated with structural changes in specific brain regions. Furthermore, these outcomes can vary according to strain, g[...]texto impreso
Azcoitia Elías, Iñigo ; Arévalo, María Ángeles ; Santos Galindo, María ; Acaz Fonseca, Estefanía ; García Segura, Luis Miguel | Academic Press Inc Elsevier Science | 2013-02Astrocytes and microglia respond to central nervous system (CNS) injury with changes in morphology, proliferation, migration and expression of inflammatory regulators. This phenomenon is known as reactive gliosis. Activation of astrocytes and mi[...]texto impreso
Cermenati, Gaia ; Audano, Matteo ; Giatti, Silvia ; Carozzi, Valentina ; Porretta Serapiglia, Carla ; Pettinato, Emanuela ; Ferri, Cinzia ; D'Antonio, Maurizio ; De Fabiani, Emma ; Crestani, Maurizio ; Scuranti, Samuele ; Sáez, Enrique ; Azcoitia Elías, Iñigo ; Calavetti, Guido ; García Segura, Luis Miguel ; Melcangi, Roberto C. ; Caruso, Donatella ; Mitro, Nico | Science Direct | 2015-04-07Myelin is a membrane characterized by high lipid content to facilitate impulse propagation. Changes in myelin fatty acid (FA) composition have been associated with peripheral neuropathy, but the specific role of peripheral nerve FA synthesis in [...]texto impreso
Estradiol, either from peripheral or central origin, activates multiple molecular neuroprotective and neuroreparative responses that, being mediated by estrogen receptors or by estrogen receptor independent mechanisms, are initiated at the membr[...]texto impreso
In addition to be an ovarian hormone, estradiol is a neurosteroid synthesized by neural cells. The brain is a steroidogenic tissue that metabolizes testosterone to estradiol. The last step in the synthesis of estradiol is catalyzed by the enzyme[...]texto impreso
Mitro, Nico ; Cermenati, Gaia ; Brioschi, Elizabetta ; Abbiati, Federico ; Audano, Matteo ; Giatti, Silvia ; Crestani, Maurizio ; De Fabiani, Emma ; Azcoitia Elías, Iñigo ; García-Segura, Luis Miguel ; Caruso, Donatella ; Melcangi, Roberto C. | Elsevier | 2014-09Diabetic peripheral neuropathy causes a decrease in the levels of dihydroprogesterone and 5- androstane-3,17-diol (3-diol) in the peripheral nerves. These two neuroactive steroids exert protective effects, by mechanisms that still remain elusive[...]texto impreso
Azcoitia Elías, Iñigo ; Arévalo, María Ángeles ; De Nicola, Alejandro F. ; García Segura, Luis Miguel | Elsevier | 2011-12Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine estrogens. Our understa[...]texto impreso
Acaz Fonseca, Estefanía ; Ortiz Rodriguez, Ana ; Azcoitia Elías, Iñigo ; García-Segura, Luis Miguel ; Arévalo, María Ángeles | Springer | 2019-04-03In the nervous system, Notch pathway has a prominent role in the control of neuronal morphology and in the determination of the astrocyte fate. However, the role of Notch in morphological astrocyte plasticity is unknown. Here, we have explored t[...]texto impreso
Yanguas Casás, Natalia ; Crespo Castrillo, Andrea ; Ceballos, María L. de ; Chowen, Julie A. ; Azcoitia Elías, Iñigo ; Arévalo, María Ángeles ; García Segura, Luis Miguel | Wiley | 2018-03Sex differences in the incidence, clinical manifestation, disease course, and prognosis of neurological diseases, such as autism spectrum disorders or Alzheimer’s disease, have been reported. Obesity has been postulated as a risk factor for cogn[...]texto impreso
Arévalo, María Ángeles ; Azcoitia Elías, Iñigo ; González Burgos, Ignacio ; García Segura, Luis Miguel | Science Direct | 2015-08Estradiol participates in the regulation of the function and plasticity of synaptic circuits in key cognitive brain regions, such as the prefrontal cortex and the hippocampus. The mechanisms elicited by estradiol are mediated by the regulation o[...]texto impreso
Mecha Rodríguez, Miriam ; Yanguas Casás, Natalia ; Feliú Martínez, Ana ; Mestre, L. ; Carrillo-Salinas, F. ; Azcoitia Elías, Iñigo ; Yong, V. W. ; Guaza Rodríguez, Carmen | Elsevier | 2019Remyelination is an endogenous process by which functional recovery of damaged neurons is achieved by reinstating the myelin sheath around axons. Remyelination has been documented in multiple sclerosis (MS) lesions and experimental models, altho[...]texto impreso
Arévalo, María Ángeles ; Azcoitia Elías, Iñigo ; García Segura, Luis Miguel | Macmillan Publishers | 2015-01Hormones regulate homeostasis by communicating through the bloodstream to the body’s organs, including the brain. As homeostatic regulators of brain function, some hormones exert neuroprotective actions. This is the case for the ovarian hormone [...]texto impreso
Crespo Castrillo, Andrea ; Yanguas Casás, Natalia ; Arévalo, María Ángeles ; Azcoitia Elías, Iñigo ; Barreto, George E. ; García Segura, Luis Miguel | Humana Press | 2018-03-26Previous studies have shown that estradiol reduces reactive gliosis after a stab wound injury in the cerebral cortex. Since the therapeutic use of estradiol is limited by its peripheral hormonal effects, it is of interest to determine whether sy[...]
