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López Rodríguez, Ana Belén ; Siopi, Eleni ; Finn, David P. ; Marchand-Leroux, Catherine ; García Segura, Luis Miguel ; Jafarian-Tehrani, Mehrnaz ; Viveros, María Paz | Oxford Open | 2015-01Traumatic brain injury (TBI) and its consequences represent one of the leading causes of death in young adults. This lesion mediates glial activation and the release of harmful molecules and causes brain edema, axonal injury, and functional impa[...]texto impreso
López Rodríguez, Ana Belén ; Mela Rivas, Virginia ; Acaz Fonseca, Estefanía ; García Segura, Luis Miguel ; Viveros, María Paz | Elsevier | 2016-05Background and purpose The rates for traumatic brain injury (TBI) have risen in the last decade. Studies in animal models and clinical trials have not yet resulted in an effective treatment for TBI. Leptin, a 16 kDa peptidic hormone is mainly kn[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Viveros, María Paz ; García Segura, Luis Miguel | Public Library of Sciences (PLOS) | 2015-06-03Traumatic brain injury (TBI) incidence rises during adolescence because during this critical neurodevelopmental period some risky behaviors increase. The purpose of this study was to assess the contribution of cannabinoid receptors (CB1 and CB2)[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Giatti, Silvia ; Caruso, Donatella ; Viveros, María Paz ; Melcangi, Roberto C. ; García Segura, Luis Miguel | Elsevier | 2015-06Traumatic brain injury (TBI) is an important cause of disability in humans. Neuroactive steroids, such as progesterone and dehydroepiandrosterone (DHEA), are neuroprotective in TBI models. However in order to design potential neuroprotective str[...]texto impreso
Developmental Sex Differences in the Metabolism of Cardiolipin in Mouse Cerebral Cortex Mitochondria
Acaz Fonseca, Estefanía ; Ortiz Rodriguez, Ana ; López Rodríguez, Ana Belén ; García Segura, Luis Miguel ; Astiz, Mariana | Springer Nature | 2017-03-06Cardiolipin (CL) is a mitochondrial-specific phospholipid. CL content and acyl chain composition are crucial for energy production. Given that estradiol induces CL synthesis in neurons, we aimed to assess CL metabolism in the cerebral cortex (CC[...]texto impreso
Estradiol biosynthesis is catalyzed by the enzyme aromatase, the product of the CYP19A1 gene. Aromatase is expressed in the brain, where it is involved not only in the control of neuroendocrine events and reproduction, but also in the regulation[...]texto impreso
Azcoitia Elías, Iñigo ; García-Caceres, Cristina ; Lagunas, Natalia ; Calmarza-Font, Isabel ; Diz Chaves, Yolanda ; García Segura, Luis Miguel ; Vaquedano, Eva ; Frago, Laura M. ; Argente, Jesús ; Chowen, Julie A. | Elsevier | 2010-11Stress during pregnancy can impair biological and behavioral responses in the adult offspring and some of these effects are associated with structural changes in specific brain regions. Furthermore, these outcomes can vary according to strain, g[...]texto impreso
Azcoitia Elías, Iñigo ; Arévalo, María Ángeles ; Santos Galindo, María ; Acaz Fonseca, Estefanía ; García Segura, Luis Miguel | Academic Press Inc Elsevier Science | 2013-02Astrocytes and microglia respond to central nervous system (CNS) injury with changes in morphology, proliferation, migration and expression of inflammatory regulators. This phenomenon is known as reactive gliosis. Activation of astrocytes and mi[...]texto impreso
Cermenati, Gaia ; Audano, Matteo ; Giatti, Silvia ; Carozzi, Valentina ; Porretta Serapiglia, Carla ; Pettinato, Emanuela ; Ferri, Cinzia ; D'Antonio, Maurizio ; De Fabiani, Emma ; Crestani, Maurizio ; Scuranti, Samuele ; Sáez, Enrique ; Azcoitia Elías, Iñigo ; Calavetti, Guido ; García Segura, Luis Miguel ; Melcangi, Roberto C. ; Caruso, Donatella ; Mitro, Nico | Science Direct | 2015-04-07Myelin is a membrane characterized by high lipid content to facilitate impulse propagation. Changes in myelin fatty acid (FA) composition have been associated with peripheral neuropathy, but the specific role of peripheral nerve FA synthesis in [...]texto impreso
Estradiol, either from peripheral or central origin, activates multiple molecular neuroprotective and neuroreparative responses that, being mediated by estrogen receptors or by estrogen receptor independent mechanisms, are initiated at the membr[...]texto impreso
In addition to be an ovarian hormone, estradiol is a neurosteroid synthesized by neural cells. The brain is a steroidogenic tissue that metabolizes testosterone to estradiol. The last step in the synthesis of estradiol is catalyzed by the enzyme[...]texto impreso
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Azcoitia Elías, Iñigo ; Arévalo, María Ángeles ; De Nicola, Alejandro F. ; García Segura, Luis Miguel | Elsevier | 2011-12Results from animal experiments showing that estradiol is neuroprotective were challenged 10 years ago by findings indicating an increased risk of dementia and stroke in women over 65 years of age taking conjugated equine estrogens. Our understa[...]texto impreso
López Rodríguez, Ana Belén ; Acaz Fonseca, Estefanía ; Spezzano, Roberto ; Giatti, Silvia ; Caruso, Donatella ; Viveros, María Paz ; Melcangi, Roberto C. ; García Segura, Luis Miguel | Endocrine Society | 2016The incidence of traumatic brain injuries (TBIs) in humans has rapidly increased in the last ten years. The most common causes are falls and car accidents. Approximately 80 000-90 000 persons per year will suffer some permanent disability as a r[...]texto impreso
Yanguas Casás, Natalia ; Crespo Castrillo, Andrea ; Ceballos, María L. de ; Chowen, Julie A. ; Azcoitia Elías, Iñigo ; Arévalo, María Ángeles ; García Segura, Luis Miguel | Wiley | 2018-03Sex differences in the incidence, clinical manifestation, disease course, and prognosis of neurological diseases, such as autism spectrum disorders or Alzheimer’s disease, have been reported. Obesity has been postulated as a risk factor for cogn[...]
