Información del autor
Autor Pérez de Lara, María Jesús |
Documentos disponibles escritos por este autor (25)
![](./images/expand_all.gif)
![](./images/collapse_all.gif)
![Selecciones disponibles](./images/orderby_az.gif)
![]()
texto impreso
Awad Alkozi, Hanan ; Navarro, Gemma ; Aguinaga, David ; Reyes-Resina, Irene ; Sánchez Naves, Juan ; Pérez de Lara, María Jesús ; Franco, Rafael ; Pintor, Jesús | The British Pharmacological Society / Wiley-Blackwell | 2020-01-04Background and Purpose: Often, glaucoma courses with elevated eye hydrostatic pression, which is regulated by endogenous melatonin. Via ?1?adrenoceptor activation, phenylephrine increases cytoplasmic [Ca2+] that is detrimental in glaucoma. The a[...]![]()
texto impreso
Yadav, Monika ; Schiavone, Nicola ; Guzmán Aránguez, Ana Isabel ; Giansanti, Fabrizio ; Papucci, Laura ; Pérez de Lara, María Jesús ; Singh, Mandeep ; Kaur, Indu Pal | Springer Verlag | 2020-04-08Statins, widely prescribed for cardiovascular diseases, are also being eyed for management of age-related macular degeneration (AMD). Poor bioavailability and blood-aqueous barrier may however limit significant ocular concentration of statins fo[...]![]()
texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Spanish General Council of Optometrists | 2017-11Purpose/aim: Glaucoma consists of a group of progressive optic neuropathies that are characterized by degeneration of the optic nerve and irreversible visual filed loss. Elevated intraocular pressure is the only proven treatable risk factor and [...]![]()
texto impreso
Yadav, Monika ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Singh, Mandeep ; Singh, Joga ; Kaur, Indu Pal | Elsevier | 2019-05-10Primary treatment for glaucoma relies on chronic instillation (daily) of intraocular pressure (IOP) lowering eye drops. Present study tends to develop and assess a novel sustained release bimatoprost loaded nanovesicular (BMT-NV) - thermosensit[...]![]()
texto impreso
El glaucoma es una de las causas más comunes de discapacidad visual y una de las enfermedades neurodegenerativas oculares más frecuentes de pérdida irreversible de visión. La afectación originada en la retina se caracteriza por la degeneración d[...]![]()
texto impreso
Martínez Águila, Alejandro ; Fonseca Vázquez, Begoña ; Pérez de Lara, María Jesús ; Miras Portugal, María Teresa ; Gómez Villafuertes, María Rosa ; Carracedo Rodríguez, Juan Gonzalo ; Pintor, Jesús | 2020-07-29Purpose: The objective of this study was to evaluate the changes in the melatoninergic receptors of DBA/2J and C57BL/6J mice with the development of glaucoma. DBA/2J mice are widely used to study the physiopathology of glaucoma due to the simila[...]![]()
texto impreso
Fonseca Vázquez, Begoña ; Martínez Águila, Alejandro ; Pérez de Lara, María Jesús ; Miras Portugal, María Teresa ; Gómez Villafuertes, María Rosa ; Pintor, Jesús | Frontiers Media | 2017-10-10Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal mode[...]![]()
texto impreso
Fonseca, Begoña ; Martínez Águila, Alejandro ; Pérez de Lara, María Jesús ; Pintor, Jesús | Springer | 2016-11Glaucoma is a neurodegenerative disease that produces blindness. The main factor associated with this disease is an abnormally elevated intraocular pressure (IOP). To date, some attempts have been made to demonstrate the role of nucleotides modu[...]![]()
texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Elsevier | 2015-05The effect of the dinucleotide P1, P4-Di (adenosine-5') tetraphosphate (Ap4A) in improving adrenergic anti-glaucomatous delivery by modifying the tight junction proteins of the corneal epithelium was evaluated. Stratified human corneal epithelia[...]![]()
texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | The British Pharmacological Society / Wiley-Blackwell | 2015-02BACKGROUND AND PURPOSE: Here, we have studied the effects of the dinucleotide P1, P4-Di (adenosine-5?) tetraphosphate (Ap4A) on corneal barrier function conferred by the tight junction (TJ) proteins and its possible involvement in ocular drug de[...]![]()
texto impreso
Martínez Águila, Alejandro ; Fonseca, Begoña ; Pérez de Lara, María Jesús ; Pintor Just, Jesús | American Society for Pharmacology and Experimental Therapeutics (ASPET) | 2016-05Melatonin is a neurohormone that is produced not only by the pineal gland but also by several ocular structures. One of the main physiologic roles of melatonin is the reduction of intraocular pressure (IOP). Using both control C57BL/6J and glauc[...]![]()
texto impreso
Alkozi, Hanan Awad ; Sánchez Naves, Juan ; Pérez de Lara, María Jesús ; Carracedo Rodríguez, Juan Gonzalo ; Fonseca, Begoña ; Martínez Águila, Alejandro ; Pintor, Jesús | John Wiley & Sons Ltd. | 2016-09-06Purpose: To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma. Methods : A total of 37 eyes of 37 patients who underwent ca[...]![]()
texto impreso
Pérez de Lara, María Jesús ; Guzmán Aránguez, Ana Isabel ; Gómez Villafuertes, María Rosa ; Gualix, Javier ; Miras Portugal, María Teresa ; Pintor, Jesús | Springer | 2018-06-08The pathogenesis of glaucoma involves numerous intracellular mechanisms including the purinergic system contribution. Furthermore, the presence and release of nucleotides and dinucleotides during the glaucomatous damage and the maintenance of de[...]![]()
texto impreso
Pérez de Lara, María Jesús ; Guzmán Aránguez, Ana Isabel ; Villa, Pedro, de la ; Díaz Hernández, Juan Ignacio ; Miras Portugal, María Teresa ; Pintor, Jesús | 2015-09-06Purpose: To study retinal extracellular ATP levels and to assess the changes in the vesicular nucleotide transporter (VNUT) expression in a murine model of glaucoma during the development of the disease. Methods: Retinas were obtained from glauc[...]![]()
texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Taylor & Francis | 2016-09Purpose: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears. Methods: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples[...]![]()
texto impreso
Melatonin is a substance synthesized in the pineal gland as well as in other organs. This substance is involved in many ocular functions, giving its synthesis in numerous eye structures. Melatonin is synthesized from serotonin through two enzyme[...]![]()
texto impreso
Colligris, Pade ; Pérez de Lara, María Jesús ; Colligris, Basilio ; Pintor, Jesús | Hindawi | 2018-07-30Dementia, including Alzheimer’s disease (AD), is a major disorder, leading to several ocular manifestations amongst the elderly population. These visual disorders may be due to retinal nerve degenerative changes, including nerve fibre layer thin[...]![]()
texto impreso
Carpena Torres, Carlos ; Pintor, Jesús ; Pérez de Lara, María Jesús ; Huete Toral, Fernando ; Crooke, Almudena ; Pastrana, Cristina ; Carracedo Rodríguez, Juan Gonzalo | Hindawi Publishing Corporation | 2020-05-30Purpose. To optimize a rabbit dry eye model induced by topical instillation of benzalkonium chloride (BAC), reduce the days of instillation of the original model by increasing the concentration of BAC from 0.1% to 0.2%. Materials and Methods. [...]![]()
texto impreso
Carpena Torres, Carlos ; Pintor, Jesús ; Pérez de Lara, María Jesús ; Toral, Fernando ; Crooke, Almudena ; Pastrana, Cristina ; Carracedo Rodríguez, Juan Gonzalo ; Cayuela López, Ana ; Sorzano Sánchez, Óscar ; Charbel, Carla ; Garzón Jiménez, Nuria ; Carballo Álvarez, Jesús ; Diz Arias, Elena ; Fernández Jiménez, Elena ; Peral Cerdá, Assumpta ; Gómez Pedrero, José Antonio ; Durán Prieto, Elena ; López Alonso, José Manuel ; Fernández Torres, Miguel Ángel ; Guzmán Aránguez, Ana Isabel ; Gómez Manzanares, Ángela ; Vázquez Moliní, Daniel ; Martínez Antón, Juan Carlos ; Bernárdez Vilaboa, Ricardo ; Mayorga Pinilla, Santiago ; Álvarez Fernández-Balbuena, Antonio ; Benítez, AntoJ. ; El Youssfi, Asmae Igalla ; León Álvarez, Alejandro ; Palomo Álvarez, Catalina ; LLedó Mayans, Victoria Eugenia ; Awad Alkozi, Hanan ; Sánchez Naves, Juan ; Martínez Alberquilla, Irene ; García Montero, María ; Ruiz Alcocer, Javier ; Madrid Costa, David ; Martínez Florentín, Gema ; Papas, Eric B. ; Medrano Muñoz, Sandra Milena ; Molina, Nancy ; Jurado, Sandra ; Oliveiros López, Juan ; Platero Alvarado, Nadiuska Cristine ; Garrido Mercado, Rafaela ; Pérez Garmendia, Carlos ; Antona Peñalba, Beatriz ; Barrio de Santos, Ana Rosa ; González Pérez, Mariano ; Pérez Garmendia, Carlos ; Serramito Blanco, María ; Privado Aroco, Ana ; Almalki, Wael ; Bodas Romero, Julia ; Ouzzani, Mohamed ; Paune, Jaume ; Calderón García, Raquel ; Pitarch Velasco, Aida ; Cebrián, José Luis ; Sánchez Pérez, Isabel ; García Rojo, Marta María ; Bonnin Arias, Cristina ; Sánchez Ramos, Celia ; Gutiérrez Jorrín, Sara Carmen ; Rodríguez Alonso, Xabier ; Laucirica Sáenz, Gorka ; Arranz Márquez, Esther ; Alonso Castellanos, Miriam ; Teus Guezala, Miguel Ángel ; Hernández Verdejo, José Luis ; Mármol Errasti, Esther ; Martín García, Beatriz ; Arriola Villalobos, Pedro ; Gómez de Liaño, Rosario ; Mínguez Caro, N ; Orduña Azcona, Javier ; Navarro Gil, Francisco Javier ; Huete Toral, Fernando ; Rodríguez Pomar, Candela ; Pastrana Robles, Cristina ; Martínez Águila, Alejandro ; Martín Gil, Alba ; Tomé de la Torre, Miguel Ángel | Facultad de Óptica y Optometría (UCM) | 2020Por cuarto año consecutivo los doctorandos de la Facultad de Óptica y Optometría de la Universidad Complutense de Madrid cuentan con un congreso propio organizado por y para ellos, el 4º PhDAY- FOO. Se trata de un congreso gratuito abierto en [...]![]()
texto impreso
Pérez de Lara, María Jesús ; Avilés Trigueros, Marcelino ; Guzmán Aránguez, Ana Isabel ; Valiente Soriano, Francisco Javier ; Villa Polo, Pedro de la ; Vidal Sanz, Manuel ; Pintor, Jesús | Elsevier | 2019-05-16Glaucoma is a common cause of visual impairment and blindness, characterized by retinal ganglion cell (RGC) death. The mechanisms that trigger the development of glaucoma remain unknown and have gained significant relevance in the study of this [...]![]()
texto impreso
The aim of this study was to assess the changes of extracellular ATP levels during the progress of Alzheimer's disease by using a murine model of the disease. Retinal nucleotide release was measured from flattened whole-mounts stimulated with 59[...]![]()
texto impreso
Melanopsin is a non-image forming photoreceptor known to be present in the retina and it is considered to have light regulated tasks among other functions. In the present work, melanopsin presence in human lens epithelial cells as well as in hum[...]![]()
texto impreso
Yadav, Monika ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Singh, Mandeep ; Singh, Joga ; Pal Kaur, Indu | Elsevier | 2019-08In vitro cytotoxicity and in vivo acute and 7 days repeat-dose ocular toxicity studies, were conducted in rabbits, in accordance with the Organisation for Economic Co-operation and Development (OECD) guidelines, for bimatoprost loaded nanovesicu[...]![]()
texto impreso
Fernández Arroyo, Salvador ; Huete Toral, Fernando ; Pérez de Lara, María Jesús ; Cádiz Gurrea, María de la Luz ; Legeai Mallet, Laurence ; Micol, Vicente ; Segura Carretero, Antonio ; Joven, Jorge ; Pintor, Jesús | Taylor & Francis | 2015-10-05Background: Imbalances in the functional binding of fibroblast growth factors (FGFs) to their receptors (FGFRs) have consequences for cell proliferation and differentiation that in chondrocytes may lead to degraded cartilage. The toxic, proinfla[...]![]()
texto impreso
Alkozi, Hanan Awad ; Pérez de Lara, María Jesús ; Sánchez Naves, Juan ; Pintor, Jesús | MDPI | 2017-04Melatonin is a molecule which has gained a great deal of interest in many areas of science; its synthesis was classically known to be in the pineal gland. However, many organs synthesize melatonin, such as several ocular structures. Melatonin is[...]