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Awad Alkozi, Hanan ; Navarro, Gemma ; Aguinaga, David ; Reyes-Resina, Irene ; Sánchez Naves, Juan ; Pérez de Lara, María Jesús ; Franco, Rafael ; Pintor, Jesús | The British Pharmacological Society / Wiley-Blackwell | 2020-01-04Background and Purpose: Often, glaucoma courses with elevated eye hydrostatic pression, which is regulated by endogenous melatonin. Via ?1?adrenoceptor activation, phenylephrine increases cytoplasmic [Ca2+] that is detrimental in glaucoma. The a[...]texto impreso
Yadav, Monika ; Schiavone, Nicola ; Guzmán Aránguez, Ana Isabel ; Giansanti, Fabrizio ; Papucci, Laura ; Pérez de Lara, María Jesús ; Singh, Mandeep ; Kaur, Indu Pal | Springer Verlag | 2020-04-08Statins, widely prescribed for cardiovascular diseases, are also being eyed for management of age-related macular degeneration (AMD). Poor bioavailability and blood-aqueous barrier may however limit significant ocular concentration of statins fo[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Spanish General Council of Optometrists | 2017-11Purpose/aim: Glaucoma consists of a group of progressive optic neuropathies that are characterized by degeneration of the optic nerve and irreversible visual filed loss. Elevated intraocular pressure is the only proven treatable risk factor and [...]texto impreso
Yadav, Monika ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Singh, Mandeep ; Singh, Joga ; Kaur, Indu Pal | Elsevier | 2019-05-10Primary treatment for glaucoma relies on chronic instillation (daily) of intraocular pressure (IOP) lowering eye drops. Present study tends to develop and assess a novel sustained release bimatoprost loaded nanovesicular (BMT-NV) - thermosensit[...]texto impreso
El glaucoma es una de las causas más comunes de discapacidad visual y una de las enfermedades neurodegenerativas oculares más frecuentes de pérdida irreversible de visión. La afectación originada en la retina se caracteriza por la degeneración d[...]texto impreso
Martínez Águila, Alejandro ; Fonseca Vázquez, Begoña ; Pérez de Lara, María Jesús ; Miras Portugal, María Teresa ; Gómez Villafuertes, María Rosa ; Carracedo Rodríguez, Juan Gonzalo ; Pintor, Jesús | 2020-07-29Purpose: The objective of this study was to evaluate the changes in the melatoninergic receptors of DBA/2J and C57BL/6J mice with the development of glaucoma. DBA/2J mice are widely used to study the physiopathology of glaucoma due to the simila[...]texto impreso
Fonseca Vázquez, Begoña ; Martínez Águila, Alejandro ; Pérez de Lara, María Jesús ; Miras Portugal, María Teresa ; Gómez Villafuertes, María Rosa ; Pintor, Jesús | Frontiers Media | 2017-10-10Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal mode[...]texto impreso
Fonseca, Begoña ; Martínez Águila, Alejandro ; Pérez de Lara, María Jesús ; Pintor, Jesús | Springer | 2016-11Glaucoma is a neurodegenerative disease that produces blindness. The main factor associated with this disease is an abnormally elevated intraocular pressure (IOP). To date, some attempts have been made to demonstrate the role of nucleotides modu[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Elsevier | 2015-05The effect of the dinucleotide P1, P4-Di (adenosine-5') tetraphosphate (Ap4A) in improving adrenergic anti-glaucomatous delivery by modifying the tight junction proteins of the corneal epithelium was evaluated. Stratified human corneal epithelia[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | The British Pharmacological Society / Wiley-Blackwell | 2015-02BACKGROUND AND PURPOSE: Here, we have studied the effects of the dinucleotide P1, P4-Di (adenosine-5?) tetraphosphate (Ap4A) on corneal barrier function conferred by the tight junction (TJ) proteins and its possible involvement in ocular drug de[...]texto impreso
Martínez Águila, Alejandro ; Fonseca, Begoña ; Pérez de Lara, María Jesús ; Pintor Just, Jesús | American Society for Pharmacology and Experimental Therapeutics (ASPET) | 2016-05Melatonin is a neurohormone that is produced not only by the pineal gland but also by several ocular structures. One of the main physiologic roles of melatonin is the reduction of intraocular pressure (IOP). Using both control C57BL/6J and glauc[...]texto impreso
Alkozi, Hanan Awad ; Sánchez Naves, Juan ; Pérez de Lara, María Jesús ; Carracedo Rodríguez, Juan Gonzalo ; Fonseca, Begoña ; Martínez Águila, Alejandro ; Pintor, Jesús | John Wiley & Sons Ltd. | 2016-09-06Purpose: To study the levels of melatonin in the aqueous humour of normotensive and hypertensive intraocular pressure (IOP) patients and to compare them to an animal model of glaucoma. Methods : A total of 37 eyes of 37 patients who underwent ca[...]texto impreso
Pérez de Lara, María Jesús ; Guzmán Aránguez, Ana Isabel ; Gómez Villafuertes, María Rosa ; Gualix, Javier ; Miras Portugal, María Teresa ; Pintor, Jesús | Springer | 2018-06-08The pathogenesis of glaucoma involves numerous intracellular mechanisms including the purinergic system contribution. Furthermore, the presence and release of nucleotides and dinucleotides during the glaucomatous damage and the maintenance of de[...]texto impreso
Pérez de Lara, María Jesús ; Guzmán Aránguez, Ana Isabel ; Villa, Pedro, de la ; Díaz Hernández, Juan Ignacio ; Miras Portugal, María Teresa ; Pintor, Jesús | 2015-09-06Purpose: To study retinal extracellular ATP levels and to assess the changes in the vesicular nucleotide transporter (VNUT) expression in a murine model of glaucoma during the development of the disease. Methods: Retinas were obtained from glauc[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Taylor & Francis | 2016-09Purpose: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears. Methods: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples[...]
