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Yadav, Monika ; Schiavone, Nicola ; Guzmán Aránguez, Ana Isabel ; Giansanti, Fabrizio ; Papucci, Laura ; Pérez de Lara, María Jesús ; Singh, Mandeep ; Kaur, Indu Pal | Springer Verlag | 2020-04-08Statins, widely prescribed for cardiovascular diseases, are also being eyed for management of age-related macular degeneration (AMD). Poor bioavailability and blood-aqueous barrier may however limit significant ocular concentration of statins fo[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Spanish General Council of Optometrists | 2017-11Purpose/aim: Glaucoma consists of a group of progressive optic neuropathies that are characterized by degeneration of the optic nerve and irreversible visual filed loss. Elevated intraocular pressure is the only proven treatable risk factor and [...]texto impreso
Yadav, Monika ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Singh, Mandeep ; Singh, Joga ; Kaur, Indu Pal | Elsevier | 2019-05-10Primary treatment for glaucoma relies on chronic instillation (daily) of intraocular pressure (IOP) lowering eye drops. Present study tends to develop and assess a novel sustained release bimatoprost loaded nanovesicular (BMT-NV) - thermosensit[...]texto impreso
Mediero Muñoz, Aránzazu ; Guzmán Aránguez, Ana Isabel ; Crooke, Almudena ; Peral Cerdá, Assumpta ; Pintor, Jesús | The Association for Research in Vision and Ophthalmology, Inc. | 2008-11Purpose. To investigate the role of ERK1/2 and RhoA/ROCK intracellular pathways in the modification of corneal re-epithelialization when stimulated by the diadenosine polyphosphates Ap4A and Ap3A. Methods. In wounded confluent SIRC (Statens Seru[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Elsevier | 2015-05The effect of the dinucleotide P1, P4-Di (adenosine-5') tetraphosphate (Ap4A) in improving adrenergic anti-glaucomatous delivery by modifying the tight junction proteins of the corneal epithelium was evaluated. Stratified human corneal epithelia[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | The British Pharmacological Society / Wiley-Blackwell | 2015-02BACKGROUND AND PURPOSE: Here, we have studied the effects of the dinucleotide P1, P4-Di (adenosine-5?) tetraphosphate (Ap4A) on corneal barrier function conferred by the tight junction (TJ) proteins and its possible involvement in ocular drug de[...]texto impreso
Guzmán Aránguez, Ana Isabel ; Fonseca, Begoña ; Carracedo Rodríguez, Juan Gonzalo ; Martín Gil, Alba ; Martínez Águila, Alejandro ; Pintor, Jesús | Contact Lens Association of Ophthalmologists | 2016-09Dry eye disease affects a substantial segment of the word population with increasing frequency. It is a multifactorial disease of the ocular surface and tear film, which causes ocular discomfort, visual disturbances, and tear instability with po[...]texto impreso
Crooke, Almudena ; Guzmán Aránguez, Ana Isabel ; Mediero Muñoz, Aránzazu ; Alarma-Estrany, Pilar ; Carracedo Rodríguez, Juan Gonzalo ; Pelaez, Teresa ; Peral Cerdá, Assumpta ; Pintor, Jesús | Taylor & Francis | 2015-01Purpose: We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. Methods: New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the c[...]texto impreso
Garranzo Asensio, María ; San Segundo Acosta, Pablo ; Povés Francés, Carmen ; Fernández Aceñero, María Jesús ; Martínez Useros, Javier ; Montero Calle, Ana ; Solís Fernández, Guillermo ; Sánchez Martínez, Mari Cruz ; Rodríguez, Nuria ; Cerón, María Ángeles ; Fernández Díez, Servando ; Domínguez Muñóz, Gemma ; Ríos, Vivian de los ; Peláez García, Alberto, Alberto ; Guzmán Aránguez, Ana Isabel ; Barderas, Rodrigo | Elsevier | 2020-03-01Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer related death worldwide. Its diagnosis at early stages would significantly improve the survival of CRC patients. The humoral immune response has been [...]texto impreso
Garranzo Asensio, María ; San Segundo Acosta, Pablo ; Povés Francés, Carmen ; Fernández Aceñero, María Jesús ; Martínez Useros, Javier ; Montero Calle, Ana ; Solís Fernández, Guillermo ; Sánchez Martínez, Maricruz ; Rodríguez Salas, Nuria ; Cerón, María Ángeles ; Fernández Díez, Servando ; Domínguez Muñóz, Gemma ; Ríos, Vivian de los ; Peláez García, Alberto, Alberto ; Guzmán Aránguez, Ana Isabel ; Barderas Manchado, Rodrigo | Elsevier | 2020-03Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer related death worldwide. Its diagnosis at early stages would significantly improve the survival of CRC patients. The humoral immune response has been [...]texto impreso
Guzmán Aránguez, Ana Isabel ; Calvo del Bosque, Patricia ; Ropero Berzal, Inés ; Pintor, Jesús | Mary Ann Liebert | 2014-11-06Purpose: Treatment with topical eye drops for long-standing ocular diseases like allergy can induce detrimental side effects. The purpose of this study was to investigate in vitro cytotoxicity of commercially preserved and unpreserved anti-aller[...]texto impreso
Pérez de Lara, María Jesús ; Guzmán Aránguez, Ana Isabel ; Gómez Villafuertes, María Rosa ; Gualix, Javier ; Miras Portugal, María Teresa ; Pintor, Jesús | Springer | 2018-06-08The pathogenesis of glaucoma involves numerous intracellular mechanisms including the purinergic system contribution. Furthermore, the presence and release of nucleotides and dinucleotides during the glaucomatous damage and the maintenance of de[...]texto impreso
Pérez de Lara, María Jesús ; Guzmán Aránguez, Ana Isabel ; Villa, Pedro, de la ; Díaz Hernández, Juan Ignacio ; Miras Portugal, María Teresa ; Pintor, Jesús | 2015-09-06Purpose: To study retinal extracellular ATP levels and to assess the changes in the vesicular nucleotide transporter (VNUT) expression in a murine model of glaucoma during the development of the disease. Methods: Retinas were obtained from glauc[...]texto impreso
Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Pérez de Lara, María Jesús ; Pintor, Jesús | Taylor & Francis | 2016-09Purpose: This study was undertaken to determine the effect of the topical application of diadenosine tetraphosphate on lactoferrin levels in rabbit tears. Methods: Diadenosine tetraphosphate was topically instilled in a single-dose, tear samples[...]texto impreso
Pelaez, Teresa ; Mediero Muñoz, Aránzazu ; Alarma-Estrany, Pilar ; Loma Lozano, Patricia ; Guzmán Aránguez, Ana Isabel ; Crooke, Almudena ; Kolligris, Basilio ; Peral Cerdá, Assumpta ; Pintor, Jesús | Real Academia Nacional de Farmacia | 2007The research on the effect of melatonin on intraocular pressure (IOP) is reviewed from the hystorical point of view of our laboratory. The original idea of melatonin modulating intraocular pressure has been improved by using selective compounds[...]
