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Granier, Sophie A ; Hidalgo, Laura ; San Millán, Álvaro ; Escudero, José Antonio ; Gutiérrez, Belén ; Brisabois, Anne ; González Zorn, Bruno | American Society for Microbiology | 2011-11The 16S rRNA methyltransferase ArmA is a worldwide emerging determinant that confers high-level resistance to most clinically relevant aminoglycosides. We report here the identification and characterization of a multidrug-resistant Salmonella en[...]texto impreso
Hidalgo, Laura ; Hopkins, Katie L ; Wareham, David W ; Gutiérrez, Belén ; González Zorn, Bruno | American Society for Microbiology | 2012-09Aminoglycosides and beta-lactams are used for the treatment of a wide range of infections due to both Gram-negative and Gram-positive. An emerging aminoglycoside resistance mechanism, methylation of the aminoacyl site of the 16S rRNA, confers [...]texto impreso
El patógeno de rumiantes Listeria ivanovii se diferencia de Listeria monocytogenes en que produce una fuerte hemolisis bizonal y una característica reacción de hemolisis cooperativa (tipo CAMP) en forma de pala con Rhodococcus equi. Hemos clonad[...]texto impreso
Delgado Blas, José Francisco ; Martínez Ovejero, Cristina ; Abadia Patiño, Lorena ; González Zorn, Bruno | American Society for Microbiology | 2016-10We studied the presence of the mobile colistin resistance gene mcr-1 in human, animal, and environmental Enterobacteriaceae samples from Cumana, Venezuela, that were collected in 2015. The mcr-1 gene was detected in 2/93 Escherichia coli isolate[...]texto impreso
Antimicrobial resistance is a major health problem. After decades of research, numerous difficulties in tackling resistance have emerged, from the paucity of new antimicrobials to the inefficient contingency plans to reduce the use of antimicrob[...]texto impreso
Valderrama, María José ; González Zorn, Bruno ; Calvo de Pablo, Pilar ; Díez Orejas, Rosalía ; Fernández Acero, Teresa ; Gil-Serna, Jessica ; Juan, Lucía de ; Martín Brieva, Humberto ; Molina Martín, María ; Navarro García, Federico ; Patiño, Belén ; Pla Alonso, Jesús ; Prieto, Daniel ; Rodríguez Fernández, Carmina ; Román González, Elvira ; Sanz Santamaría, Ana Belén ; Silóniz, María Isabel de ; Suárez, Mónica ; Vázquez, Covadonga ; Jiménez Cid, Víctor | Oxford University Press | 2018-09-01The Small World Initiative (SWI) and Tiny Earth are a consolidated and successful education programs rooted in the USA that tackle the antibiotic crisis by a crowdsourcing strategy. Based on active learning, it challenges young students to disco[...]texto impreso
Gutiérrez, Belén ; Escudero, José Antonio ; San Millán, Álvaro ; Hidalgo, Laura ; Carrilero Aguado, Laura ; Martínez Ovejero, Cristina ; Santos López, Alfonso ; Thomas López, Daniel ; González Zorn, Bruno | American Society for Microbiology | 2012-05Arm/Rmt methyltransferases have emerged recently in pathogenic bacteria as enzymes that confer high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the G1405 residue in the 16S rRNA (like ArmA and RmtA to -E). In pro[...]texto impreso
Escudero, José Antonio ; San Millán, Álvaro ; Gutiérrez, Belén ; Hidalgo, Laura ; La Ragione, Roberto M ; AbuOun, Manal ; Galimand, Marc ; Ferrándiz, María José ; Domínguez Rodríguez, Lucas ; de la Campa, Adela G ; González Zorn, Bruno | American Society for Microbiology | 2011-12Streptococcus suis is an emerging zoonotic pathogen. With the lack of an effective vaccine, antibiotics remain the main tool to fight infections caused by this pathogen. We have previously observed a reserpine-sensitive fluoroquinolone (FQ) effl[...]texto impreso
San Millán, Álvaro ; Garcia Cobos, Silvia ; Escudero, José Antonio ; Hidalgo, Laura ; Gutiérrez, Belén ; Carrilero Aguado, Laura ; Campos, José ; González Zorn, Bruno | American Society for Microbiology | 2010-04Plasmid pB1000 is a mobilizable replicon bearing the bla(ROB-1) beta-lactamase gene that we have recently described in Haemophilus parasuis and Pasteurella multocida animal isolates. Here we report the presence of pB1000 and a derivative plasmid[...]texto impreso
Hidalgo, Laura ; Gutiérrez, Belén ; Martínez Ovejero, Cristina ; Carrilero Aguado, Laura ; Matrat, Stephanie ; Saba, Courage K S ; Santos López, Alfonso ; Thomas López, Daniel ; Hoefer, Andreas ; Suárez Rodríguez, Mónica ; Santurde Sánchez, Gloria ; Martín Espada, Carmen ; González Zorn, Bruno | American Society for Microbiology | 2013-09Seven Klebsiella pneumoniae isolates from dogs and cats in Spain were found to be highly resistant to aminoglycosides, and ArmA methyltransferase was responsible for this phenotype. All isolates were typed by multilocus sequence typing (MLST) as[...]texto impreso
Gómez-Lucía y Duato , María Esperanza ; Gibello Prieto , Alicia ; Cutuli Simón , María Teresa ; Blanco Gutiérrez, María del Mar ; Fernández-Garayzabal Fernández , José Francis ; Aranaz Martín , Alicia ; Blanco Cancelo , José Luis ; García Sánchez, Marta Eulalia ; González Zorn, Bruno | Editorial Complutense | 2007Para el Proyecto de Innovación Educativa se ha realizado un CD como complemento a las prácticas de la Licenciatura de Veterinaria que tienen un componente microbiológico. Incluye aspectos fundamentales del ejercicio profesional (Toma de Muestras[...]texto impreso
Rigottier-Gois, Lionel ; Alberti, Adriana ; Houel, Armel ; Taly, Jean-François ; Palcy, Philippe ; Manson, Janet ; Pinto, Daniela ; Matos, Renata C ; Carrilero Aguado, Laura ; Montero Serra, Natalia ; Tariq, Muhammad ; Karsens, Harma ; Repp, Christian ; Kropec, Andrea ; Budin-Verneuil, Aurélie ; Benachour, Abdellah ; Sauvageot, Nicolas ; Bizzini, Alain ; Gilmore, Michael S ; Bessières, Philippe ; Kok, Jan ; Huebner, Johannes ; Lopes, Fatima ; González Zorn, Bruno ; Hartke, Axel ; Serror, Pascale | Public Library Science | 2011Spread of antibiotic resistance among bacteria responsible for nosocomial and community-acquired infections urges for novel therapeutic or prophylactic targets and for innovative pathogen-specific antibacterial compounds. Major challenges are po[...]texto impreso
Jiménez Cid, Víctor ; Calvo de Pablo, Pilar ; Román González, Elvira ; Patiño Álvarez, Aurora Belén ; González Zorn, Bruno ; Gómez-Luz Centelles, María Luisa ; Molina Martín, María ; Martín Brieva, Humberto ; Escudero García-Calderón, José Antonio ; Pavón Vergés, Mónica ; Rodríguez Fernández, Carmina ; Díaz del Toro, Silvia ; Rodríguez Escudero, Isabel ; Vázquez Estévez, Covadonga ; Bezos Garrido, Javier ; Álvarez Sánchez, Julio ; Amaro Torres, Francisco ; Suárez Rodríguez, Mónica ; Gil Serna, Jéssica ; Fernández-Acero Bascones, Teresa ; Sanz Santamaría, Ana Belén ; González Rubio, Gema ; Jiménez Gutiérrez, Elena ; Coronas Serna, Julia María ; Valenti Sanguino, Marta ; del Val Oriza, Elba ; Sellers Moya, Ángela ; Prieto, Alicia ; Arias, Patricia ; Sastre Vergara, Lucía | Proyecto ApS UCM | 2020-09-30MicroMundo es un proyecto de Ciencia Ciudadana basado en aprendizaje activo, en el que estudiantes de ESO y Bachillerato, objeto del servicio, coordinados por equipos de estudiantes universitarios, objeto del aprendizaje, desarrollan un proyecto[...]texto impreso
Søndergaard, Annette ; San Millán, Álvaro ; Santos López, Alfonso ; Nielsen, Signe M ; González Zorn, Bruno ; Nørskov-Lauritsen, Niels | American Society for Microbiology | 2012-09TEM-1 is the dominant ?-lactamase of Haemophilus influenzae and can be located on small plasmids. Three distinct plasmids with sizes from 4,304 to 5,646 nucleotides (nt) were characterized: pA1606, pA1209, and pPN223. In addition to TEM-1 and a [...]texto impreso
San Millán, Álvaro ; Escudero, José Antonio ; Gutiérrez, Belén ; Hidalgo, Laura ; Garcia, Nerea ; Llagostera, Montserrat ; Domínguez Rodríguez, Lucas ; González Zorn, Bruno | American Society for Microbiology | 2009-08In most gram-negative bacteria, acquired multiresistance is conferred by large plasmids compiling numerous antimicrobial resistance genes. Here, we show an evolutionary alternative strategy used by Pasteurella multocida to become resistant to mu[...]
