| Título: | Preclinical Development of Artificial Tears Based on an Extract of Artemia Salina Containing Dinucleotides in Rabbits |
| Autores: | Carpena Torres, Carlos ; Pintor, Jesús ; Huete Toral, Fernando ; Rodríguez Pomar, Candela ; Martínez Águila, Alejandro ; Carracedo Rodríguez, Juan Gonzalo |
| Tipo de documento: | texto impreso |
| Editorial: | Taylor & Francis, 2020-07-07 |
| Dimensiones: | application/pdf |
| Nota general: | info:eu-repo/semantics/restrictedAccess |
| Idiomas: | |
| Palabras clave: | Estado = Publicado , Materia = Ciencias Biomédicas: Medicina: Oftalmología , Materia = Ciencias Biomédicas: Óptica y optometría: Anatomía ocular , Tipo = Artículo |
| Resumen: |
Purpose: To evaluate the preclinical efficacy of eye drops based on an extract of Artemia salina on the ocular surface of rabbits. Tear secretion, tear break-up time and corneal staining were measured. Material and methods: A preclinical and short-term prospective study was performed. Twenty New Zealand white rabbits were divided into five groups, with four rabbits per group, each receiving a different concentration of Artemia salina. In each rabbit, an extract of Artemia salina (2%, 4%, 6%, 8% or 10%) was randomly instilled in one eye and saline solution (negative control) in the other eye. Tear secretion, tear break-up time and corneal staining were measured before and after the instillation of five drops per eye (one drop per hour) on the same day. Results: In tear secretion, there was an increase of 43.88 ± 6.73% with 4% Artemia salina in comparison with its baseline measurement (P = .049). The rest of the groups did not show differences (P ? 0.05). For tear break-up time, none of the groups showed differences (P ? 0.05), while for corneal staining score, there was an improvement of 0.88 ± 0.83 with 4% Artemia salina (P = .038) and a deterioration of 0.50 ± 0.83 with control solution (P = .008). Conclusions: Short-term instillation of eye drops with 4% Artemia salina produced both stimulation of tear secretion and a slight improvement of physiological corneal staining. Besides, all the doses of up to 10% Artemia salina did not produce undesirable side effects on the ocular surface. Therefore, these eye drops are presented as a possible new treatment for dry eye due to their secretagogue properties and ocular surface regeneration. |
| En línea: | https://eprints.ucm.es/id/eprint/61734/1/Carracedo_2020_Preclinical%20Development%20of%20Artificial%20Tears%20Based%20on%20an%20Extract%20of%20Artemia%20Salina%20Containing%20Dinucleotides%20in%20Rabbits.pdf |
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