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Montes-Casado, María ; Sanvicente, Adrián ; Casarrubios Molina, Laura ; Feito Castellano, María José ; Rojo, J.M. ; Vallet Regí, María ; Arcos Navarrete, Daniel ; Portoles, Pilar ; Portolés Pérez, María Teresa | MDPI | 2020-11-05Mesoporous bioactive glass nanospheres (NanoMBGs) have high potential for clinicalapplications. However, the impact of nanoparticles on the immune system needs to be addressed. In this study, the biocompatibility of SiO2-CaO NanoMBGs was evalua[...]texto impreso
Feito Castellano, María José ; Díez-Orejas, Rosalia ; Cicuendez, Monica ; Casarrubios, Laura ; Rojo, José María ; Portolés Pérez, María Teresa | Elsevier | 2019-04-01Macrophages play a key role in nanoparticle removal and are primarily responsible for their uptake and trafficking in vivo. Due to their functional plasticity, macrophages display a spectrum of phenotypes between two extremes indentified as pro-[...]texto impreso
Matesanz Sancho, María Concepción ; Feito Castellano, María José ; Oñaderra Sánchez, Mercedes ; Ramirez Santillán, Cecilia ; Casa, Carmen da ; Arcos Navarrete, Daniel ; Vallet Regí, María ; Rojo, José María ; Portolés Pérez, María Teresa | Elsevier | 2014-02-15Hypothesis: Synthetic hydroxyapatite (HA) and Si substituted hydroxyapatite (SiHA) are calcium phosphate ceramics currently used in the field of dentistry and orthopaedic surgery. The preparation of both biomaterials as polycrystalline solid pie[...]texto impreso
Cicuendez, Monica ; Portoles, Pilar ; Montes Casado, María ; Izquierdo-Barba, Isabel ; Vallet Regí, María ; Portolés Pérez, María Teresa | Royal Society of Chemistry | 2014-06-14The interaction of new nanocomposite mesoporous glass/hydroxyapatite (MGHA) scaffolds with immune cells involved in both innate and acquired immunity has been studied in vitro as an essential aspect of their biocompatibility assessment. Since th[...]texto impreso
Feito Castellano, María José ; Serrano, M. C. ; Oñaderra Sánchez, Mercedes ; Matesanz Sancho, María Concepción ; Sánchez Salcedo, Sandra ; Arcos Navarrete, Daniel ; Vallet Regí, María ; Portolés Pérez, María Teresa | Royal Society of Chemistry | 2016-09-21Vascular endothelial growth factor (VEGF) plays an essential role in angiogenesis and vascular homeostasis. Endothelial progenitor cells (EPCs) are primitive bone marrow cells participating in neovascularization and revascularization processes, [...]texto impreso
Gómez-Cerezo, Natividad ; Casarrubios, L. ; Morales, I. ; Feito Castellano, María José ; Vallet Regí, María ; Arcos Navarrete, Daniel ; Portolés Pérez, María Teresa | Elsevier | 2018-10-15A mesoporous bioactive glass (MBG) of molar composition 75SiO2-20CaO-5P2O5 (MBG-75S) has been synthetized as a potential bioceramic for bone regeneration purposes. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), nitroge[...]texto impreso
Díez Orejas, Rosalía ; Casarrubios, Laura ; Feito Castellano, María José ; Rojo, J.M. ; Vallet Regí, María ; Arcos Navarrete, Daniel ; Portolés Pérez, María Teresa | Elsevier | 2021-02-15The use of nanoparticles for intracellular drug delivery could reduce the toxicity and side effects of the drug but, the uptake of these nanocarriers could induce adverse effects on cells and tissues after their incorporation. Macrophages play a[...]texto impreso
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Maycas, Marta ; Portolés Pérez, María Teresa ; Matesanz Sancho, María Concepción ; Buendía, Irene ; Linares, Javier ; Feito Castellano, María José ; Arcos Navarrete, Daniel ; Vallet Regí, María ; Plotkin, Lilian I. ; Esbrit, Pedro ; Gortázar, Arancha R. | Wiley | 2017-12Diabetes mellitus (DM) induces bone deterioration, while mechanical stimulation promotes osteocyte-driven bone formation. We aimed to evaluate the interaction of acute exposure (24 h) to high glucose (HG) with both the pro-survival effect confer[...]texto impreso
Casarrubios, Laura ; Gómez-Cerezo, Natividad ; Feito Castellano, María José ; Vallet Regí, María ; Arcos Navarrete, Daniel ; Portolés Pérez, María Teresa | Elsevier | 2018-12-01Mesoporous nanospheres in the system SiO2-CaO (NanoMBGs) with a hollow core surrounded by a radial arrangement of mesopores were characterized, labeled with FITC (FITC-NanoMBGs) and loaded with ipriflavone (NanoMBG-IPs) in order to evaluate thei[...]texto impreso
Casarrubios, Laura ; Gomez Cerezo, Natividad ; Feito Castellano, María José ; Vallet Regí, María ; Arcos Navarrete, Daniel ; Portolés Pérez, María Teresa | MDPI | 2020-12-21The incorporation and effects of hollow mesoporous nanospheres in the systemSiO2–CaO (nanoMBGs) containing ipriflavone (IP), a synthetic isoflavone that prevents osteoporosis, were evaluated. Due to their superior porosity and capability to host[...]texto impreso
Cicuendez, Monica ; Fernándes, Márcia ; Ayán-Varela, Miguel ; Oliveira, Helena ; Feito Castellano, María José ; Díez Orejas, Rosalía ; Paredes, Juan I. ; Villar-Rodil, Silvia ; Vila, Mercedes ; Portolés Pérez, María Teresa ; Duarte, Iola F. | Elsevier | 2020-02The preparation of graphene-based nanomaterials (GBNs) with appropriate stability and biocompatibility is crucial for their use in biomedical applications. In this work, three GBNs differing in size and/or functionalization have been synthetized[...]texto impreso
Gomez Cerezo, Natividad ; Casarrubios, Laura ; Saiz-Pardo, M. ; Ortega, L. ; De Pablo, D. ; Díaz-Güemes, I. ; Fernández-Tomé, E. ; Enciso, S ; Sanchez-Margallo, F. M. ; Portolés Pérez, María Teresa ; Arcos Navarrete, Daniel ; Vallet Regí, María | Elsevier | 2019-04-05Macroporous scaffolds made of a SiO2-CaO-P2O5 mesoporous bioactive glass (MBG) and ?polycaprolactone (PCL) have been prepared by robocasting. These scaffolds showed an excellent in vitro biocompatibility in contact with osteoblast like cells (Sa[...]texto impreso
Cicuendez, Monica ; Flores, Joana ; Oliveira, Helena ; Portolés Pérez, María Teresa ; Vallet Regí, María ; Vila, Mercedes ; Duarte, Lola F | Elsevier | 2018-05-18Nanographene oxide (nGO)-mediated hyperthermia has been increasingly investigated as a localized, minimally invasive anticancer therapeutic approach. Near InfraRed (NIR) light irradiation for inducing hyperthermia is particularly attract[...]texto impreso
Cicuendez, Monica ; Doadrio Villarejo, Juan Carlos ; Hernandez, ana ; Portolés Pérez, María Teresa ; Izquierdo-Barba, Isabel ; Vallet Regí, María | Elsevier | 2017-11-09Multifunctional-therapeutic three-dimensional (3D) scaffolds have been prepared. These biomaterials are able to destroy the S. aureus bacterial biofilm and to allow bone regeneration at the same time. The present study is focused on the design o[...]
