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Pérez García, Selene ; Gutiérrez Cañas, Irene ; Seoane Valiño, Iria V. ; Fernández, Julián ; Mellado, Mario ; Leceta Martínez, Javier ; Tío, Laura ; Villanueva Romero, Raúl ; Juarranz Moratilla, Yasmina ; Pérez Gomáriz, Rosa María | 2016-09Current description of osteoarthritis includes the involvement of synovial inflammation. Studies contributing to understanding the mechanisms of cross-talk and feedback among the joint tissues could be relevant to the development of therapies th[...]texto impreso
Villares, Ricardo ; Criado, Gabriel ; Juarranz Moratilla, Yasmina ; López Santalla, Mercedes ; García-Cuesta, Eva María ; Rodríguez Frade, José Miguel ; Leceta Martínez, Javier ; Lucas, Pilar ; Pablos, José L. ; Martínez-A., Carlos ; Garin, Marina I. ; Gomáriz, Rosa P. ; Mellado, Mario | Frontiers Media | 2018-05-25Evidence indicates an intimate connection between the neuroendocrine and the immune systems. A number of in vitro and in vivo studies have demonstrated growth hormone (GH) involvement in immune regulation. The GH receptor is expressed by several[...]texto impreso
Jimeno, Rebeca ; Leceta Martínez, Javier ; Garín, Marina ; Ortiz, Ana M. ; Mellado, Mario ; Rodríguez Frade, José Miguel ; Martínez, Carmen ; Pérez García, Selene ; Pérez Gomáriz, Rosa María ; Juarranz Moratilla, Yasmina | The Society for Leukocyte Biology. | 2015-08Several studies in humans indicate the implication of Th17 cells in RA. Therapies targeting their pathogenicity, as well as their plasticity to the Th17/1 phenotype, could ameliorate the progression of the pathology. The neuroendocrine environme[...]texto impreso
Jimeno Lumeras, Rebeca Gema ; Pérez Gomáriz, Rosa Mª ; Garín, Marina ; Gutiérrez Cañas, Irene ; González Álvaro, Isidoro ; Carrión Caballo, Mar ; Galindo, María ; Leceta Martínez, Javier ; Juarranz Moratilla, Yasmina | Springer | 2015Our aim is to study the behavior of memory Th cells (Th17, Th17/1, and Th1 profiles) from early rheumatoid arthritis (eRA) patients after their in vitro activation/expansion to provide information about its contribution to RA chronicity. Moreove[...]texto impreso
Jimeno Lumeras, Rebeca Gema ; Leceta Martínez, Javier ; Martínez, Carmen ; Gutiérrez-Cañas, Irene ; Carrión Caballo, Mar ; Pérez García, Selene ; Garín, Marina ; Mellado, Mario ; Pérez Gomáriz, Rosa María ; Juarranz Moratilla, Yasmina | Springer | 2014-11The cytokine microenvironment modulates CD4 T cell differentiation causing the shift of naïve CD4 T cells into different cell subsets. This process is also regulated by modulators such as VIP, a neuropeptide with known immunomodulatory propertie[...]
