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Documentos disponibles de esta editorial (380)
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Mesoporous silica materials (MSM) have a great surface area and a high pore volume, meaning that they consequently have a large loading capacity, and have been demonstrated to be unique candidates for the treatment of different pathologies, incl[...]texto impreso
The enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these mat[...]texto impreso
Nanoparticles have become a powerful tool in oncology not only as carrier of the highly toxic chemotherapeutic drugs but also as imaging contrast agents that provide valuable information about the state of the disease and its progression. The en[...]texto impreso
Mesoporous silica nanoparticles have attracted much attention in recent years as drug and gene delivery systems for biomedical applications. Among their most beneficial features for biomedicine, we can highlight their biocompatibility and their [...]texto impreso
Vallet Regí, María ; Colilla, Montserrat ; Izquierdo-Barba, Isabel ; Manzano García, Miguel | MDPI | 2017-12-25This manuscript reviews the recent progress on mesoporous silica nanoparticles as drug delivery systems. Their intrinsic structural, textural and chemical features permit to design versatile multifunctional nanosystems with the capability to tar[...]texto impreso
Current chemotherapy treatments lack of great selectivity towards tumoral cells, which 13 leads to nonspecific drug distribution and subsequent side effects. In this regard, the use of 14 nanoparticles able to encapsulate and release therapeutic[...]texto impreso
Bone diseases, such as bone cancer, bone infection and osteoporosis, constitute a major issue for modern societies as a consequence of their progressive ageing. Even though these pathologies can be currently treated in the clinic, some of those [...]texto impreso
In recent decades, the development of the Conceptual Metaphor Theory, put forward by Lakoff and other scholars. In this light, metaphor and metonymy have been found to provide a semantic motivation for a considerable number of idiomatic expressi[...]texto impreso
Ugarte Ruiz, María ; Florez Cuadrado, Diego ; Wassenaar, Trudy M ; Porrero, María Concepción ; Domínguez Rodríguez, Lucas | MDPI | 2015Seeking a sensitive protocol, culture-dependent methods were compared to detect thermophilic Campylobacter species in untreated urban effluents. We evaluated various combinations of selective media, with and without an enrichment steps, as well [...]texto impreso
Belda Aguilar, Ignacio ; Ruiz, Javier ; Esteban Fernández, Adelaida ; Navascués, Eva ; Marquina Díaz, Domingo ; Santos de la Sen, Antonio ; Moreno Arribas, M. Victoria | MDPI | 2017-01-24Wine is a complex matrix that includes components with different chemical natures, the volatile compounds being responsible for wine aroma quality. The microbial ecosystem of grapes and wine, including Saccharomyces and non-Saccharomyces yeasts,[...]texto impreso
González Rubio, Gema ; Fernández Acero, Teresa ; Martín, Humberto ; Molina Martín, María | MDPI | 2019-04-05Mitogen-activated protein kinases (MAPKs) are key mediators of signaling in fungi, participating in the response to diverse stresses and in developmental processes. Since the precise regulation of MAPKs is fundamental for cell physiology, fungi [...]texto impreso
This paper deals with the problem of designing and choosing auctioning mechanisms for multiple commonly ranked objects as, for instance, keyword auctions in search engines on Internet. We shall adopt the point of view of the auctioneer who has t[...]texto impreso
Muehlig, A. ; Jahn, I.J. ; Heidler, J. ; Jahn, M. ; Weber, K. ; Sheen, P. ; Zimic, M. ; Cialla-May, D. ; Popp, J. | MDPI | 2019-12-06T21:04:48ZThe prodrug pyrazinamide (PZA) is metabolized by the mycobacteria to pyrazinoic acid (POA), which is expelled into the extracellular environment. PZA resistance is highly associated to a lack of POA efflux. Thus, by detecting a reduction of the [...]texto impreso
Muehlig, A. ; Jahn, I.J. ; Heidler, J. ; Jahn, M. ; Weber, K. ; Sheen, P. ; Zimic, M. ; Cialla-May, D. ; Popp, J. | MDPI | 2019-08-08T15:23:44ZThe prodrug pyrazinamide (PZA) is metabolized by the mycobacteria to pyrazinoic acid (POA), which is expelled into the extracellular environment. PZA resistance is highly associated to a lack of POA efflux. Thus, by detecting a reduction of the [...]texto impreso
Monitoring long-term trends in the evolution of the anthropogenic night sky brightness is a demanding task due to the high dynamic range of the artificial and natural light emissions and the high variability of the atmospheric conditions that de[...]texto impreso
This study analyzes soil sealing and its repercussions in the loss of fertile soils, which are more appropriate for agriculture use. Also, soil sealing increases flood risk. The main objective is to estimate soil loss by sealing in the Guadarram[...]texto impreso
Cardenes, Victor ; Merinero Palomares, Raúl ; Rubio Ordoñez, Álvaro ; Cnudde, Veerle ; García Guinea, Javier ; Pitcairn, Iain K. | MDPI | 2020-05-19It is widely accepted that metamorphism induces a remobilization of iron sulfides, sweeping away original ones while creating new ones. This paper analyzes size distributions of iron sulfides in several samples from the Caples and Torlesse terra[...]texto impreso
Colella, Barbara ; Colardo, Mayra ; Iannone, Gianna ; Contadini, Claudia ; Saiz Ladera, Cristina ; Fuoco, Claudia ; Barilà, Daniela ; Velasco Díez, Guillermo | MDPI | 2020-08-13Epidermal Growth Factor receptor (EGFR) is a tyrosine kinase receptor widely expressed on the surface of numerous cell types, which activates several downstream signalling pathways involved in cell proliferation, migration and survival. EGFR alt[...]texto impreso
Despite major efforts in scientific literature to explain and understand the social determinants of health inequalities, the complex association between social causes and health outcomes remains empirically questionable and theoretically puzzlin[...]texto impreso
Consumer dietary habits have drastically changed in recent decades and functional beverages now have a strong position in the market. The majority of these beverages are produced using simple processes that use raw products, such as cereals, leg[...]texto impreso
Guagliardo, Roberta ; Merckx, Pieterjan ; Zamborlin, Agata ; Backer, Lynn de ; Echaide Torreguitar, Mercedes ; Pérez Gil, Jesús ; Smedt, Stefaan C. de ; Raemdonck, Koen | MDPI | 2019-08-23Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by vario[...]texto impreso
Both the prevalence of antibiotic resistance and the increased biofilm-associated infections are boosting the demand for new advanced and more effective treatment for such infections. In this sense, nanotechnology offers a ground-breaking platfo[...]texto impreso
The development of nanomachines able to operate at the nanoscale, performing complex tasks such as drug delivery, precision surgery, or cell detection, constitutes one of the most important challenges in nanotechnology. The principles that rule [...]texto impreso
Nanoparticles designed for diagnosing and treating different diseases have impacted the scientific research in biomedicine, and are expected to revolutionize the clinic in the near future through a new area called nanomedicine. In the last few y[...]texto impreso
Infectious diseases hold third place in the top 10 causes of death worldwide and were responsible for more than 6.7 million deaths in 2016. Nanomedicine is a multidisciplinary field which is based on the application of nanotechnology for medical[...]texto impreso
The use of therapeutic proteins plays a fundamental role in the treatment of numerous diseases. The low physico-chemical stability of proteins in physiological conditions put their function at risk in the human body until they reach their target[...]texto impreso
This work reports on a computational analysis of how a modified perovskite cell can work as a refractometric sensor by generating surface plasmon resonances at its front surface. Metal-dielectric interfaces are necessary to excite plasmonic reso[...]texto impreso
Fernández Albarral, José Antonio ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, Rosa de ; López Villarín, Nerea ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Licastro, Ester ; Inarejos García, Antonio M. ; Almodóvar, Paula ; Pinazo Durán, Mª Dolores ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | MDPI | 2019-08-22Glaucoma is a neurodegenerative disease characterized by the loss of retinal ganglion cells (RGCs). An increase in the intraocular pressure is the principal risk factor for such loss, but controlling this pressure does not always prevent glaucom[...]texto impreso
Sánchez, María C. ; Ribeiro Vidal, Honorato ; Bartolomé, Begoña ; Figuero Ruiz, Elena ; Moreno-Arribas, M. Victoria ; Sanz Alonso, Mariano ; Herrera González, David | MDPI | 2020The worrying rise in antibiotic resistances emphasizes the need to seek new approaches for treating and preventing periodontal diseases. The purpose of this study was to evaluate the antibacterial and anti-biofilm activity of cranberry in a vali[...]texto impreso
Sociology was born as a discipline that analyzed the process of modernization of Western European societies. However, in turn, this science was developing a predictive, prophetic vision of the future of human communities, assuming that they were[...]texto impreso
Fernandez-Lozano, Javier ; González-Díez, Alberto ; Gutiérrez-Alonso, Gabriel ; Carrasco González, Rosa María ; Pedraza Gilsanz, Javier de ; García-Talegón, Jacinta ; Alonso-Gavilán, Gaspar ; Remondo, Juan ; Bonachea, Jaime ; Morellón, Mario | MDPI | 2018This contribution discusses the potential of UAV-assisted (unmanned aerial vehicles) photogrammetry for the study and preservation of mining heritage sites using the example of Roman gold mining infrastructure in northwestern Spain. The study ar[...]texto impreso
Pastor, María Jesús ; Sánchez, Ignacio ; Campo, José A. ; Schmidt, Rainer ; Cano, Mercedes | MDPI | 2018-04Ionic liquid crystals (ILCs) are a class of materials that combine the properties of liquid crystals (LCs) and ionic liquids (ILs). This type of materials is directed towards properties such as conductivity in ordered systems at different temper[...]texto impreso
The rapid and accurate determination of specific circulating biomarkers at different molecular levels with non- or minimally invasive methods constitutes a major challenge to improve the breast cancer outcomes and life quality of patients. In th[...]texto impreso
Truchado, Daniel A. ; Díaz-Piqueras, José Manuel ; Gomez-Lucia, Esperanza ; Doménech, Ana ; Milá, Borja ; Pérez Tris, Javier ; Schmidt-Chanasit, Jonas ; Cadar, Daniel ; Benítez Rico, Laura | MDPI | 2019-12-11Sequence-independent amplification techniques have become important tools for virus discovery, metagenomics, and exploration of viral diversity at the global scale, especially in remote areas. Here, we describe the detection and genetic characte[...]texto impreso
Galisteo Pretel, Alberto ; Pérez del Pulgar, Helena ; Olmeda García, Ángeles Sonia ; Gonzalez-Coloma, Azucena ; Barrero, Alejandro F. ; Quílez del Moral, José Francisco | MDPI | 2019-11-16Naturally occurring nootkatone, with reported insecticidal and acaricidal properties, has been used as a lead to generate molecular diversity and, consequently, new insect antifeedant and ixodicidal compounds. A total of 22 derivatives were gene[...]texto impreso
García-Díaz, Marta ; Patiño Álvarez, Belén ; Vázquez, Covadonga ; Gil-Serna, Jessica | MDPI | 2019-11-06Aflatoxin (AF) contamination of maize is a major concern for food safety. The use of chemical fungicides is controversial, and it is necessary to develop new effective methods to control Aspergillus flavus growth and, therefore, to avoid the pre[...]texto impreso
Prieto, Nuria ; Burbano, Carmen ; Iniesto, Elisa ; Rodríguez, Julia ; Cabanillas, Beatriz ; Crespo, Jesús ; Pedrosa, Mercedes ; Muzquiz, Mercedes ; del Pozo, Juan ; Linacero de la Fuente, Rosario ; Cuadrado, Carmen | MDPI | 2014-05-05Food allergies to hazelnut represent an important health problem in industrialized countries because of their high prevalence and severity. Food allergenicity can be changed by several processing procedures since food proteins may undergo modifi[...]texto impreso
Fresco Taboada, Alba ; Serra, Immacolata ; Fernández Lucas, Jesús ; Acebal Sarabia, Carmen ; Arroyo, Miguel ; Terreni, Marco ; Mata Riesco, Isabel de la | MDPI | 2014-07-31Nucleoside 2'-deoxyribosyltransferase (NDT) from the psychrophilic bacterium Bacillus psychrosaccharolyticus CECT 4074 has been cloned and produced for the first time. A preliminary characterization of the recombinant protein indicates that the [...]texto impreso
Bolgiani, Pedro ; Fernández González, Sergio ; Valero Rodríguez, Francisco ; Merino, Andrés ; García Ortega, Eduardo ; Sánchez, José Luis ; Martín, María Luisa | MDPI | 2018-09Deep convection is a threat to many human activities, with a great impact on aviation safety. On 7 July 2017, a widespread torrential precipitation event (associated with a cut-off low at mid-levels) was registered in the vicinity of Madrid, cau[...]texto impreso
Meza-Hernández, Mayra ; Villarreal-Zegarra, David ; Saavedra-Garcia, Lorena | MDPI | 2020-07-14T00:02:34ZThe purpose of this paper was to determine the foods and beverages offered in the city of Lima, Peru, that would be subject to front-of-package warning labels (octagons) according to the thresholds for the two phases (6 and 39 months after the a[...]texto impreso
Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Cadena Santoyo, Manuel ; Ferreras Amez, Antonio ; Monsalve Córdova, Blanca ; García Martín, Elena Salobrar ; Muñóz Blanco, José L ; Urcelay Segura, José Luis ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020-01-29Background: This study compared functional and structural visual changes in Friedreich ataxia (FRDA) patients with healthy controls (HC) and correlated these changes with neurological disability. Methods: Eight FRDA Spanish patients and eight HC[...]texto impreso
García Martín, Elena Salobrar ; Méndez Hernández, Carmen D. ; Hoz Montañana, Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; Fernández Arrabal, José A. ; Rojas Lozano, Pilar ; Wang, Surina ; García Feijoo, Julián ; Gil, Pedro ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020In Alzheimer’s disease (AD), vascular changes could be caused by amyloid beta (A?) aggregates replacing the contractile smooth musculature of the arteriole walls. These changes happen in the brain vascular network, but also in the eye, and are r[...]texto impreso
Maté-González, Miguel Ángel ; Sánchez-Aparicio, Luis Javier ; Sáez Blázquez, Cristina ; Carrasco García, Pedro ; Álvarez-Alonso, David ; de Andrés-Herrero, María ; García-Davalillo, Juan Carlos ; González-Aguilera, Diego ; Hernández Ruiz, Mario ; Jordá Bordehore, Luis ; López Carnicero, Carlos ; Mora, Rocío | MDPI | 2019This paper is focused on the Middle Paleolithic rock shelter called “Abrigo de San Lázaro”, placed in the Eresma River valley (Segovia, Spain). In this area, a multisource geomatic approach is used. On the one hand, the external envelope of the [...]texto impreso
Multiple studies have been carried out on the correct estimation of the damages (direct tangible losses) associated with floods. However, the complex analysis and the multitude of variables conditioning the damage estimation, as well as the unce[...]texto impreso
This paper deals with an infective process of type SIS, taking place in a closed population of moderate size that is inspected periodically. Our aim is to study the number of inspections that find the epidemic process still in progress. As the u[...]texto impreso
This paper proposes risk sharing strategies, which allow insurers to cooperate and diversify non-systemic risk. We deal with both deviation measures and coherent risk measures and provide general mathematical methods applying to optimize them al[...]texto impreso
Elshorbagy, Mahmoud Hamdy Mohamed ; Cuadrado Conde, Alexander ; Gómez Pedrero, José Antonio ; Alda, Javier | MDPI | 2020-02-11The bolometric effect allows us to electrically monitor spectral characteristics of plasmonic sensors; it provides a lower cost and simpler sample characterization compared with angular and spectral signal retrieval techniques. In our device, a [...]texto impreso
Gómez Ballesteros, Miguel ; López Cano, José Javier ; Bravo Osuna, Irene ; Herrero Vanrell, Rocío ; Molina Martínez, Irene Teresa | MDPI | 2019The combination of acetazolamide-loaded nano-liposomes and Hydroxypropyl methylcellulose (HPMC) with similar components to the preocular tear film in an osmoprotectant media (trehalose and erythritol) is proposed as a novel strategy to increase [...]texto impreso
Garrido Tarrio, Antonio ; Cruces, Julia ; Ceprián, Noemí ; Vara Ameigeiras, Elena ; Fuente del Rey, Mónica de la | MDPI | 2019-02-12Oxidative and inflammatory stresses are closely related processes, which contribute to age-associated impairments that affect the regulatory systems such as the immune system and its immunosenescence. Therefore, the aim of this work was to confi[...]texto impreso
Gesteiro, Eva ; Guijarro, Luis ; Sánchez Muníz, Francisco J. ; Vidal-Carou, María del Carmen ; Troncoso, Ana ; Venanci, Lluis ; Jimeno, Vicente ; Quilez, Joan ; Anadón, Arturo ; González-Gross, Marcela | MDPI | 2019Internationally recognized Spanish experts in the food industry, nutrition, toxicology, sustainability, and veterinary science met in Madrid on July 2018 to develop a consensus about palm oil (PO) as a food ingredient. Their aim was to provide a[...]texto impreso
Lantero Bringas, Esther ; Matallanas Peñas, Beatriz ; Pascual, Susana ; Callejas Hervás, Carmen | MDPI | 2018-06-28The European Union (EU) is facing the recent arrival of the bacterium Xylella fastidiosa. Its fast spread has caused great alarm because of the economic impact it implies for the agroeconomy of European countries. Among its insect vectors, Phila[...]texto impreso
Velasco Bucheli, Rodrigo ; Hormigo, Daniel ; Fernández-Lucas, Jesús ; Torres Ayuso, Pedro ; Alfaro Ureña, Yohana ; Saborido Modia, Ana ; Serrano Aguirre, Lara ; García, José Luis ; Ramón, Fernando ; Acebal Sarabia, Carmen ; Santos de la Sen, Antonio ; Arroyo Sánchez, Miguel ; Mata Riesco, Isabel de la | MDPI | 2020-07-01Many Gram-negative bacteria produce N-acyl-homoserine lactones (AHLs), quorum sensing (QS) molecules that can be enzymatically inactivated by quorum quenching (QQ) processes; this approach is considered an emerging antimicrobial alternative. In [...]texto impreso
Aragonés Tapia, Juan Ignacio ; Tapia-Fonllem, César ; Poggio Lagares, Lucía ; Fraijo-Sing, Blanca | MDPI | 2017-02-13This study applies the “psychometric paradigm” of risk perception to the heavy mineral spill in the Sonora River (Mexico). A total of 241 inhabitants of the polluted area with a mean age of 46.3 years participated in the study, completing an int[...]texto impreso
Yacamán Ochoa, Carolina ; Matarán Ruiz, Alberto ; Mata Olmo, Rafael ; Macías Figueroa, Álvaro ; Torres Rodríguez, Adolfo | MDPI | 2020-06-20Discussions on food security in the Global North have raised questions about the capacity of peri-urban organic agriculture to provide sufficient healthy food for the urban market. Dealing with food security requires more attention to how to pro[...]texto impreso
Adversarial classification (AC) is a major subfield within the increasingly important domain of adversarial machine learning (AML). So far, most approaches to AC have followed a classical game-theoretic framework. This requires unrealistic commo[...]texto impreso
Fernández Trapero, María ; Pérez Díaz, Carmen ; Espejo Porras, Francisco ; Lago Femia, Eva de ; Fernández Ruiz, Javier | MDPI | 2020-02-11The phytocannabinoid-based medicine Sativex® is currently marketed for the treatment of spasticity and pain in multiple sclerosis patients and is being investigated for other central and peripheral pathological conditions. It may also serve in V[...]texto impreso
Hübbers, Anna ; Hennings, Julia ; Lambertz, Daniela ; Haas, Ute ; Trautwein, Christian ; Nevzorova, Yulia A. ; Sonntag, Roland ; Liedtke, Christian | MDPI | 2020-05-05Liver fibrosis is a wound healing process in response to chronic liver injury, which is characterized by the accumulation of extracellular collagen produced by Hepatic Stellate Cells (HSCs). This process involves cell cycle re-entry and prolifer[...]texto impreso
Lantero Bringas, Esther ; Matallanas Peñas, Beatriz ; Pascual, Susana ; Ochando González, María Dolores ; Callejas Hervás, Carmen | MDPI | 2020-06-26The olive fruit fly (olf) Bactrocera oleae is the most damaging olive pest. The intensive use of organophosphates (OPs) to control it, led to an increase in resistance in field populations. This study assesses the presence and distribution of th[...]texto impreso
Phytoestrogens are plant-derived polyphenols with a structure similar to human estrogens. The three main groups of phytoestrogens, isoflavones, ellagitannins, and lignans, are transformed into equol, urolithins, and enterolignans, respectively, [...]texto impreso
Aldas, Miguel ; Pavon, Cristina ; López-Martínez, Juan ; Arrieta Dillon, Marina Patricia | MDPI | 2020Fully bio-based materials based on thermoplastic starch (TPS) were developed starting from corn starch plasticized with glycerol. The obtained TPS was further blended with five pine resin derivatives: gum rosin (GR), disproportionated gum rosin [...]texto impreso
Bats have an important role in the ecosystem, and therefore an effective detection of their prevalence can contribute to their conservation. At present, the most commonly methodology used in the study of bats is the analysis of echolocation call[...]texto impreso
Stivers, Nicole S. ; Islam, Ashraful ; Reyes-Reyes, Elsa M. ; Casson, Lavona K. ; Aponte, José C. ; Vaisberg, Abraham J. ; Hammond, Gerald B. ; Bates, Paula J. | MDPI | 2018-11-30T22:50:35ZWe previously reported on the isolation and biological activities of plagiochiline A (1), a 2,3-secoaromadendrane-type sesquiterpenoid from the Peruvian medicinal plant, Plagiochila disticha. This compound was found to have antiproliferative eff[...]texto impreso
González Cano, Agustín ; Navarrete Fernández, María Cruz ; Esteban, Óscar ; Díaz Herrera, Natalia | MDPI | 2014A review of the surface plasmon resonance (SPR) transducers based on tapered fibers that have been developed in the last years is presented. The devices have proved their good performance (specifically, in terms of sensitivity) and their versati[...]texto impreso
Vázquez Gómez, Marta ; Heras-Molina, Ana ; García-Contreras, Consolación ; Pesántez-Pacheco, José Luis ; Torres-Rovira, Laura ; Martinez-Fernandez, Beatriz ; González, Jorge ; Encinas Cerezo, Teresa ; Astiz, Susana ; Ovilo, Cristina ; Isabel Redondo, Beatriz ; González Bulnes, Antonio | MDPI | 2019-11-08Maternal supplementation with the polyphenol hydroxytyrosol in a swine model of intrauterine growth restriction (IUGR) improves the fetal oxidative status, decreases the appearance of low birth-weight neonates and favors growth during early post[...]texto impreso
Rivera de la Torre, Esperanza ; Palacios Ortega, Juan ; Gavilanes, José G. ; Martínez del Pozo, Álvaro ; García Linares, Sara | MDPI | 2019Animal venoms are complex mixtures of highly specialized toxic molecules. Cnidarians and arachnids produce pore-forming proteins (PFPs) directed against the plasma membrane of their target cells. Among PFPs from cnidarians, actinoporins stand ou[...]texto impreso
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Capote-Moreno, Ana ; Ramos Alonso, Eva ; Egea, Javier ; López-Muñoz, Francisco ; Gil-Martín, Emilio ; Romero Martinez, Manuel Alejandro | MDPI | 2019-11-02The wide variety of epigenetic controls available is rapidly expanding the knowledge of molecular biology even overflowing it. At the same time, it can illuminate unsuspected ways of understanding the etiology of cancer. New emerging therapeutic[...]texto impreso
Cuesta Mayorga, Iris ; Astilleros García-Monge, José Manuel ; Fernández-Díaz, Lourdes | MDPI | 2019-03-13In this work, we aimed to experimentally study the nucleation and growth of CaCO3 phases precipitated from supersaturated aqueous solutions in the presence of varying concentrations of sulphate oxyanion. The experiments were conducted under pH c[...]texto impreso
Bizhani, Hasti ; Katbab, Ali Asghar ; López Hernández, Emil ; Miranda Pantoja, José Miguel ; López Manchado, Miguel A. ; Verdejo, Raquel | MDPI | 2020-10Hybrid ethylene-propylene-diene-monomer (EPDM) nanocomposite foams were produced via compression molding with enhanced electromagnetic wave absorption efficiency. The hybrid filler, consisting of 20 phr ferroelectric barium titanate (BT) and var[...]texto impreso
Ausín Benito, Berta ; Muñoz López, Manuel ; Castellanos López, Miguel Ángel ; García, Sara | MDPI | 2020-03-15The prevalence of anxiety disorders over the last year among seniors ranged from 3.6% to 17.2%. The most prevalent disorders are specific phobias. Data are needed concerning the consequences of specific phobia disorder on the level of functionin[...]texto impreso
A recent concern in the field of dyslexia studies is the lack of awareness and attention to university students suffering from this condition. If this problem is serious in countries where the relative opacity of the writing system allows for an[...]texto impreso
In wireless body sensor network (WBSNs), the human body has an important effect on the performance of the communication due to the temporal variations caused and the attenuation and fluctuation of the path loss. This fact suggests that the trans[...]texto impreso
Castillo Romero, Rafael ; Torre, Lorena de la ; García Ochoa, Félix ; Ladero Galán, Miguel ; Vallet Regí, María | MDPI | 2020-10-24The synthesis of MCM-41mesoporous silica nanoparticles (MSNs) of controlled sizes and porous structure has been performed at laboratory and pilot plant scales. Firstly, the effects of the main operating conditions (TEOS addition rate, nanopartic[...]texto impreso
Pérez García, Selene ; Carrión Caballo, Mar ; Gutiérrez-Cañas, Irene ; Villanueva-Romero, Raúl ; Castro Moreno, David ; Martínez, Carmen ; González-Álvaro, Isidoro ; Blanco, Francisco J. ; Juarranz Moratilla, Yasmina ; Gomáriz, Rosa P. | MDPI | 2019-12-22The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical[...]texto impreso
Úbeda Palenque, José ; Bonshoms, Martí ; Iparraguirre, Joshua ; Sáez, Lucía ; de la Fuente, Ramón ; Janssen, Lila ; Concha, Ronald ; Vásquez, Pool ; Masías, Pablo | MDPI | 2018This work investigates the timing, paleoclimatic framework and inter-hemispheric teleconnections inferred from the glaciers last maximum extension and the deglaciation onset in the Arid Tropical Andes. A study area was selected to the northeastw[...]texto impreso
Marine, Nicolás ; Arnaiz-Schmitz, Cecilia ; Herrero-Jáuregui, Cristina ; O Cabrera, Manuel Rodrigo de la ; Escudero, David ; Schmitz García, María Fe | MDPI | 2020-08-25Landscape conservation efforts in many European countries focus on cultural landscapes, which are part of the cultural identity of people, have a great heritage significance, improve the living standards of local populations and provide valuable[...]texto impreso
Carracedo Añón, Julia María ; Ramírez-Carracedo, Rafael ; Martínez de Toda, Irene ; Vida Rueda, Carmen ; Alique, Matilde ; Fuente del Rey, Mónica de la ; Ramírez-Chamond, Rafael | MDPI | 2018-05-17Carbamylation is a post-translational modification of proteins that may partake in the oxidative stress-associated cell damage, and its increment has been recently proposed as a “hallmark of aging”. The molecular mechanisms associated with aging[...]texto impreso
Gil Madrona, Pedro ; Romero Martínez, Sonia ; Sáez-Gallego, Nieves ; Ordóñez Camacho, Xavier | MDPI | 2019The present research aimed to study the psycho-motor performance of five-year-old children with different body mass indices (BMI). A total of 694 pre-school children in the province of Albacete-Spain participated. Their performance in motor, per[...]texto impreso
Weigand Talavera, Rosa María ; Sánchez Balmaseda, Margarita María ; Guerra Pérez, José Manuel | MDPI | 2015-09We have numerically studied the influence of the absorption modulation depth of carbon-based saturable absorbers (graphene and carbon nanotubes (CNTs)) on the Q-switched regime of a diode-pumped Nd:YLF laser. A short-length cavity was used with [...]texto impreso
Ferreira Sánchez, María del Rosario ; Moreno Verdú, Marcos ; Cano-de-la-Cuerda, Roberto | MDPI | 2020-02-06Rigidity is one of the cardinal symptoms of Parkinson’s disease (PD). Present in up 89% of cases, it is typically assessed with clinical scales. However, these instruments show limitations due to their subjectivity and poor intra- and inter-rate[...]texto impreso
Genetic algorithms (GAs) are a class of evolutionary algorithms inspired by Darwinian natural selection. They are popular heuristic optimisation methods based on simulated genetic mechanisms, i.e., mutation, crossover, etc. and population dynami[...]texto impreso
A physical system out of thermal equilibrium is a resource for obtaining useful work when a heat bath at some temperature is available. Information Heat Engines are the devices which generalize the Szilard cylinders and make use of the celebrate[...]texto impreso
In this article, we first present and discuss eighteenth-century descriptions of minerals that contributed decisively to the development of crystallography. Remarkably, these old crystallographic descriptions included morphologies with symmetrie[...]texto impreso
Soler, Albert ; Arregui García-Rovés, Lucía ; Arroyo Sánchez, Miguel ; Mendoza, José ; Muras, Andrea ; Álvarez, Cristina ; García-Vera, Cristina ; Marquina Díaz, Domingo ; Santos de la Sen, Antonio ; Serrano Barrero, Susana Lourdes | MDPI | 2018-05-18Quorum sensing (QS) is a mechanism dependent on bacterial density. This coordinated process is mediated by the synthesis and the secretion of signal molecules, called autoinducers (AIs). N-acyl-homoserine lactones (AHLs) are the most common AIs [...]texto impreso
To prevent microbial growth and its consequences, preservatives such as sorbic acid or its salts, commonly known as sorbates, are added to foods. However, some moulds and yeasts are capable of decarboxylating sorbates and producing 1,3-pentadien[...]texto impreso
Torres, Sandra ; Abdullah, Zeinab ; Brol, Maximilian J. ; Hellerbrand, Claus ; Fernández, Mercedes ; Fiorotto, Romina ; Klein, Sabine ; Königshofer, Philipp ; Liedtke, Christian ; Lotersztajn, Sophie ; Nevzorova, Yulia A. ; Schierwagen, Robert ; Reiberger, Thomas ; Uschner, Frank Erhard ; Tacke, Frank ; Weiskirchen, Ralf ; Trebicka, Jonel | MDPI | 2020-03-16Molecular and cellular research modalities for the study of liver pathologies have been tremendously improved over the recent decades. Advanced technologies offer novel opportunities to establish cell isolation techniques with excellent purity, [...]texto impreso
Macías-Rodríguez, Ricardo U. ; Inzaugarat, María Eugenia ; Ruiz-Margáin, Astrid ; Nelson, Leonard J. ; Trautwein, Christian ; Cubero, Francisco Javier | MDPI | 2020Ferroptosis has emerged as a new type of cell death in different pathological conditions, including neurological and kidney diseases and, especially, in different types of cancer. The hallmark of this regulated cell death is the presence of iron[...]texto impreso
Palomo-López, Patricia ; Losa-Iglesias, Marta Elena ; Becerro de Bengoa Vallejo, Ricardo ; López-López, Daniel ; Rodríguez Sanz, David ; Ántolín-Gil, Marta San ; Martiniano, João ; Calvo Lobo, César | MDPI | 2020Background: This study aimed to adapt the Spanish version of the Assessment of Stress in Nursing Students (ASNS) (shorter form) instrument for Spanish podiatry students, labeling the new tool as the Spanish version of Assessment of Stress in Pod[...]texto impreso
Anthropogenic lead pollution is an environmental problem that threatens the quality of soils and waters and endangers living organisms in numerous surface and subsurface habitats. Lead coprecipitation on mineral surfaces through dissolution-recr[...]texto impreso
Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Cadena Santoyo, Manuel ; Fernández Arrabal, José A. ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Santos García, Irene ; Lago Femia, Eva de ; Urcelay Segura, José Luis ; Ramirez Sebastian, Jose Manuel ; Hoz Montañana, Rosa de ; Salazar Corral, Juan José | MDPI | 2021-02-07The neurodegenerative disease amyotrophic lateral sclerosis (ALS) affects the spinal cord, brain stem, and cerebral cortex. In this pathology, both neurons and glial cells are affected. However, few studies have analyzed retinal microglia in ALS[...]texto impreso
Fernández Arrabal, José A. ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Marco López, Eva María ; Martín Sánchez, Beatriz ; Flores Salguero, Elena ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Barrios Sabador, Vicente ; Avilés Trigueros, Marcelino ; Valiente Soriano, Francisco Javier ; Miralles de Imperial-Ollero, Juan A. ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel ; López Gallardo, Meritxell ; Ramírez Sebastián, Ana Isabel | MDPI | 2021-02-19Signaling mediated by cytokines and chemokines is involved in glaucoma-associated neuroinflammation and in the damage of retinal ganglion cells (RGCs). Using multiplexed immunoassay and immunohistochemical techniques in a glaucoma mouse model at[...]texto impreso
Multiobjective stochastic programming is a field that is well suited to tackling problems that arise in many fields: energy, financial, emergencies, among others; given that uncertainty and multiple objectives are usually present in such problem[...]texto impreso
Figueroa-Angulo, Elisa E. ; Calla-Choque, Jaeson S. ; Mancilla-Olea, Maria Inocente ; Arroyo, Rossana | MDPI | 2019-02-06T14:59:05ZIron homeostasis is highly regulated in vertebrates through a regulatory system mediated by RNA-protein interactions between the iron regulatory proteins (IRPs) that interact with an iron responsive element (IRE) located in certain mRNAs, dubbe[...]texto impreso
González de Vallejo, Luis I. ; Hernández Gutiérrez, Luis E. ; Miranda, Ana ; Ferrer-Vidal, Mercedes | MDPI | 2020-06-06In volcanic regions, rockfalls represent a major hazard strongly conditioned by the geomechanical behaviour of volcanic materials, the geomorphological characteristics of the relief and the climatic conditions. Volcanic rocks possess very differ[...]texto impreso
Díaz-García, Diana ; Montalbán-Hernández, Karla ; Mena-Palomo, Irene ; Achimas-Cadariu, Patriciu ; Rodríguez Diéguez, Antonio ; Eduardo, López-Collado ; Prashar, Sanjiv ; Ovejero Paredes, Karina ; Filice, Marco ; Fischer-Fodor, Eva ; Gómez-Ruiz, Santiago | MDPI | 2020-06-03The synthesis, characterization and cytotoxic activity against different cancer cell lines of various mesoporous silica-based materials containing folate targeting moieties and a cytotoxic fragment based on a triphenyltin(IV) derivative have bee[...]texto impreso
In 2005, our group described for the first time the structural characterization at the atomic scale of bioactive glasses and the influence of the glasses’ nanostructure in their reactivity in simulated body fluids. In that study, two bioactive s[...]texto impreso
Montalvo, Javier ; Ruiz-Labrador, Enrique ; Montoya-Bernabéu, Pablo ; Acosta Gallo, Belén | MDPI | 2019Rural–urban gradients offer an appropriate ecological framework for understanding relevant social issues to sustainability and policy planning. We tested the hypothesis that human population growth rate at a local scale is indirectly driven by s[...]texto impreso
Moya, Alberto ; Archilla Sanz, Diego ; Navarro Palma, Elena ; Hernando Grande, Antonio ; Marín Palacios, María Pilar | MDPI | 2019-07-12Co-based amorphous microwires presenting the giant magnetoimpedance effect are proposed as sensing elements for high sensitivity biosensors. In this work we report an experimental method for contactless detection of stress, temperature, and liqu[...]texto impreso
Encina Vara, Alberto de la ; Hidalgo Herrero, Mercedes ; Llana Díaz, Luis Fernando ; Rubio Díez, Fernando | MDPI | 2020-05-26It is not easy to debug lazy functional programs. The reason is that laziness and higherorder complicates basic debugging strategies. Although there exist several debuggers for sequential lazy languages, dealing with parallel languages is much h[...]texto impreso
Benavides, F. ; Sutovsky, P. ; López, V. ; Kennedy, C. ; Echevarría, L. | MDPI | 2020-07-14T00:00:56ZThe guinea pig, as a livestock species, is still developing and growing throughout Peru and neighboring countries, as reflected by its increasing export since 2000. However, the selection of proven fertile males is tedious due to the absence of [...]