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Villanueva Romero, Raúl ; Gutiérrez Cañas, Irene ; Carrión Caballo, Mar ; González Álvaro, Isidoro ; Rodríguez Frade, José Miguel ; Mellado, Mario ; Martínez, Carmen ; Gomáriz, Rosa P. ; Juarranz Moratilla, Yasmina | Nature Research | 2019-05-14Vasoactive Intestinal Peptide (VIP) is an important immunomodulator of CD4+ cells in normal and pathological conditions, which exerts its anti-infammatory and immunomodulatory actions through VPAC receptors, VPAC1 and VPAC2. Only a decrease in t[...]texto impreso
Las quimioquinas son una familia de proteínas de bajo peso molecular caracterizada por su capacidad de inducir la migración y activación de diferentes poblaciones leucocitarias. En los últimos años ha cobrado importancia el papel que juegan en o[...]texto impreso
Rodríguez Frade, José Miguel ; Martínez Muñoz, Laura ; Villares, Ricardo ; Cascio, Graciela ; Lucas, Pilar ; Pérez Gomáriz, Rosa María ; Mellado, Mario | Elsevier | 2016Chemokines and their receptors take part in many physiological and pathological processes, and their dysregulated expression is linked to chronic inflammatory and autoimmune diseases, immunodeficiencies, and cancer. The chemokine receptors, memb[...]texto impreso
Villares, Ricardo ; Criado, Gabriel ; Juarranz Moratilla, Yasmina ; López Santalla, Mercedes ; García-Cuesta, Eva María ; Rodríguez Frade, José Miguel ; Leceta Martínez, Javier ; Lucas, Pilar ; Pablos, José L. ; Martínez-A., Carlos ; Garin, Marina I. ; Gomáriz, Rosa P. ; Mellado, Mario | Frontiers Media | 2018-05-25Evidence indicates an intimate connection between the neuroendocrine and the immune systems. A number of in vitro and in vivo studies have demonstrated growth hormone (GH) involvement in immune regulation. The GH receptor is expressed by several[...]texto impreso
Jimeno, Rebeca ; Leceta Martínez, Javier ; Garín, Marina ; Ortiz, Ana M. ; Mellado, Mario ; Rodríguez Frade, José Miguel ; Martínez, Carmen ; Pérez García, Selene ; Pérez Gomáriz, Rosa María ; Juarranz Moratilla, Yasmina | The Society for Leukocyte Biology. | 2015-08Several studies in humans indicate the implication of Th17 cells in RA. Therapies targeting their pathogenicity, as well as their plasticity to the Th17/1 phenotype, could ameliorate the progression of the pathology. The neuroendocrine environme[...]
