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Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa, de ; García Martín, Elena Salobrar ; Rojas, Pilar ; Fernández Arrabal, José A. ; López Cuenca, Inés ; Rojas López, Blanca ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | IntechOpen | 2018-11The optic nerve (ON) is constituted by the axons of the retinal ganglion cells (RGCs). These axons are distributed in an organized pattern from the soma of the RGC to the lateral geniculated nucleus (where most of the neurons synapse). The key p[...]texto impreso
García Martín, Elena Salobrar ; Méndez Hernández, Carmen D. ; Hoz Montañana, Rosa de ; Ramírez Sebastián, Ana Isabel ; López Cuenca, Inés ; Fernández Arrabal, José A. ; Rojas Lozano, Pilar ; Wang, Surina ; García Feijoo, Julián ; Gil, Pedro ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | MDPI | 2020In Alzheimer’s disease (AD), vascular changes could be caused by amyloid beta (A?) aggregates replacing the contractile smooth musculature of the arteriole walls. These changes happen in the brain vascular network, but also in the eye, and are r[...]texto impreso
Rojas Lozano, Pilar ; Ramírez Sebastián, Ana Isabel ; Cadena Santoyo, Manuel ; Fernández Arrabal, José A. ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Santos García, Irene ; Lago Femia, Eva de ; Urcelay Segura, José Luis ; Ramirez Sebastian, Jose Manuel ; Hoz Montañana, Rosa de ; Salazar Corral, Juan José | MDPI | 2021-02-07The neurodegenerative disease amyotrophic lateral sclerosis (ALS) affects the spinal cord, brain stem, and cerebral cortex. In this pathology, both neurons and glial cells are affected. However, few studies have analyzed retinal microglia in ALS[...]texto impreso
Fernández Arrabal, José A. ; García Martín, Elena Salobrar ; Martínez Páramo, Rebeca ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Ramirez Sebastian, Jose Manuel ; Salazar Corral, Juan José | Elsevier | 2018-10-28Alzheimer's disease (AD) is a neurodegenerative dementia characterized by the deposition of extracellular ?-amyloid (A?) plaques and the presence of neurofibrillary tangles. Until now, the techniques used to analyze these deposits have been diff[...]texto impreso
Fernández Arrabal, José A. ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Marco López, Eva María ; Martín Sánchez, Beatriz ; Flores Salguero, Elena ; García Martín, Elena Salobrar ; López Cuenca, Inés ; Barrios Sabador, Vicente ; Avilés Trigueros, Marcelino ; Valiente Soriano, Francisco Javier ; Miralles de Imperial-Ollero, Juan A. ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel ; López Gallardo, Meritxell ; Ramírez Sebastián, Ana Isabel | MDPI | 2021-02-19Signaling mediated by cytokines and chemokines is involved in glaucoma-associated neuroinflammation and in the damage of retinal ganglion cells (RGCs). Using multiplexed immunoassay and immunohistochemical techniques in a glaucoma mouse model at[...]texto impreso
García Martín, Elena Salobrar ; López Cuenca, Inés ; Sánchez Puebla, Lídia ; Hoz Montañana, María Rosa de ; Fernández Arrabal, José A. ; Ramírez Sebastián, Ana Isabel ; Bravo Ferrer, Isbel ; Medina Alonso, Violeta ; Moro Sánchez, María Ángeles ; Saido, Takaomi C. ; Saito, Takashi ; Salazar Corral, Juan José ; Ramirez Sebastian, Jose Manuel | Frontiers Media | 2021-01-15Background: Alzheimer’s disease (AD) may present retinal changes before brain pathology, suggesting the retina as an accessible biomarker of AD. The present work is a diachronic study using spectral domain optical coherence tomography (SD-OCT) t[...]texto impreso
Fernández Arrabal, José A. ; Julián López, Esther, de ; Soler Domínguez, Carmen ; Hoz Montañana, María Rosa de ; López Cuenca, Inés ; García Martín, Elena Salobrar ; Ramirez Sebastian, Jose Manuel ; Pinazo Durán, Mª Dolores ; Salazar Corral, Juan José ; Ramírez Sebastián, Ana Isabel | Multidisciplinary Digital Publishing Institute | 2021-02-27Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-relat[...]
