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García Martín, Elena Salobrar ; Hoyas, Irene ; Leal, Mercedes ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Yubero Pancorbo, Raquel ; Gil, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Hindawi Publising Corp. | 2015-06-08Decreased thickness of the retinal nerve fiber layer (RNFL) may reflect retinal neuronal-ganglion cell death. A decrease in the RNFL has been demonstrated in Alzheimer’s disease (AD) in addition to aging by optical coherence tomography (OCT). Tw[...]texto impreso
Gracia Pacheco, Pablo de ; Gallego Collado, Beatriz Isabel ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Hoz Montañana, María Rosa de ; Salazar Corral, Juan José ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Public Library of Science | 2015-11-18Proliferation of microglial cells has been considered a sign of glial activation and a hallmark of ongoing neurodegenerative diseases. Microglia activation is analyzed in animal models of different eye diseases. Numerous retinal samples are requ[...]texto impreso
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Gallego Collado, Beatriz Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salinas Navarro, Manuel Ángel ; Ortín Martínez, Arturo ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Biomed Central Ltd | 2012-05-12Background Ocular hypertension is a major risk factor for glaucoma, a neurodegenerative disease characterized by an irreversible decrease in ganglion cells and their axons. Macroglial and microglial cells appear to play an important role in the [...]texto impreso
Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Gallego Collado, Beatriz Isabel ; García Martín, Elena Salobrar ; Valiente Soriano, Francisco Javier ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Elsevier | 2015Most studies employing experimental models of unilateral glaucoma have used the normotensive contralateral eye as the normal control. However, some studies have recently reported the activation of the retinal macroglia and microglia in the uninj[...]texto impreso
Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ruiz, Emilio ; Tejerina Sánchez, Teresa ; Ramirez Sebastian, Jose Manuel ; Triviño Casado, Alberto | Elsevier | 2006-09-26This study evaluates hypercholesterolemic rabbits, examining the retinal changes in Müller cells and astrocytes as well as their variations after a period of normal blood-cholesterol values induced by a standard diet. New Zealand rabbits were di[...]texto impreso
Rojas López, María Blanca ; Gallego Collado, Beatriz Isabel ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Hoz Montañana, María Rosa de ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto | BioMed Central Ltd. | 2014-07-26Background: Glaucomatous optic neuropathy, a leading cause of blindness, can progress despite control of intraocular pressure - currently the main risk factor and target for treatment. Glaucoma progression shares mechanisms with neurodegenerativ[...]texto impreso
García Martín, Elena Salobrar ; Hoz Montañana, María Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Yubero Pancorbo, Raquel ; Gil Gregorio, Pedro ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Hindawi Publishing Corporation | 2015-05-20Purpose. To analyze in mild Alzheimer's disease (MAD) patients, GDS-4 (Reisberg Scale), whether or not some psychophysical tests (PTs) support OCT macular findings in the same group of MAD patients reported previously. Methods. Twenty-three MAD [...]texto impreso
Hoz Montañana, Rosa de ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Salazar Corral, Juan José ; Gallego Collado, Beatriz Isabel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Hindawi Publishing Corporation | 2016-04-14Due to their permanent and close proximity to neurons, glial cells perform essential tasks for the normal physiology of the retina. Astrocytes andM¨uller cells (retinal macroglia) provide physical support to neurons and supplement them with seve[...]texto impreso
Hoz Montañana, María Rosa de ; Gallego Collado, Beatriz Isabel ; Ramírez Sebastián, Ana Isabel ; Rojas López, María Blanca ; Salazar Corral, Juan José ; Valiente Soriano, Francisco Javier ; Avilés Trigueros, Marcelino ; Villegas Pérez, María Paz ; Vidal Sanz, Manuel ; Triviño Casado, Alberto ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2013-12-18In the mouse model of unilateral laser-induced ocular hypertension (OHT) the microglia in both the treated and the normotensive untreated contralateral eye have morphological signs of activation and up-regulation of MHC-II expression in comparis[...]texto impreso
Salazar Corral, Juan José ; Gallego-Pinazo, Roberto ; Hoz Montañana, María Rosa de ; Pinazo-Durán, María Dolores ; Rojas López, María Blanca ; Ramírez Sebastián, Ana Isabel ; Serrano Espinosa, Manuel ; Ramirez Sebastian, Jose Manuel | Public Library Science | 2013-06-07Tumour-suppressor genes, such as the p53 gene, produce proteins that inhibit cell division under adverse conditions, as in the case of DNA damage, radiation, hypoxia, or oxidative stress (OS). The p53 gene can arrest proliferation and trigger de[...]
