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Yazicioglu, Tolga ; Mühlfeld, Christian ; Autilio, Chiara ; Huang, Cheng-Kai ; Bär, Christian ; Dittrich-Breiholz, Oliver ; Thum, Thomas ; Pérez Gil, Jesús ; Schmiedl, Andreas ; Brandenberger, Christina | American Physiological Society | 2020-10-14Morbidity and mortality rates in acute lung injury (ALI) increase with age. As alveolar epithelial type II cells (AE2) are crucial for lung function and repair, we hypothesized that aging promotes senescence in AE2 and contributes to the severit[...]texto impreso
De Corso, Eugenio ; Anzivino, Roberta ; Galli, Jacopo ; Baroni, Silvia ; Di Nardo, Walter ; De Vita, Carla ; Salvati, Antonio ; Autilio, Chiara ; Settimi, Stefano ; Mele, Dario ; Paludetti, Gaetano ; Mullol, Joaquin | Wiley | 2019Objective: The aim of our study was to analyze the montelukast effectiveness in improving oculonasal symptoms, patient-reported outcomes (PROs), and eosinophilic biomarkers in patients with nonallergic rhinitis eosinophilic syndrome (NARES).Meth[...]texto impreso
Autilio, Chiara ; Shankar-Aguilera, Shivani ; Minucci, Angelo ; Touqui, Lhoussaine ; De Luca, Daniele | American Physiological Society | 2019-02-21Hypothermia can modify surfactant composition and function. Secretory phospholipase A2 (sPLA2) hydrolyses surfactant phospholipids and is important in the pathobiology of several critical respiratory disorders. We hypothesize that sPLA2 activity[...]texto impreso
Foligno, Silvia ; Loi, Barbara ; Pezza, Lucilla ; Piastra, Marco ; Autilio, Chiara ; De Luca, Daniele | Wiley | 2020-06-23Since the discovery of surfactant, a large amount of knowledge has been accumulated about its biology and pharmacology. Surfactant is the cornerstone of neonatal respiratory critical care, but its proteins and phospholipids are produced in vario[...]texto impreso
Autilio, Chiara ; Echaide Torreguitar, Mercedes ; Benachi, Alexandra ; Marfaing-Koka, Anne ; Capoluongo, Ettore D. ; Pérez-Gil, Jesús ; De Lucca, Daniele | Elsevier | 2017-03Objective: To determine the diagnostic accuracy of the surfactant adsorption test (SAT) as a predictor for the need for surfactant replacement therapy in neonates with respiratory distress syndrome (RDS). Study design Amniotic fluid samples were[...]texto impreso
Hidalgo Román, Alberto ; García-Mouton, Cristina ; Autilio, Chiara ; Carravilla, Pablo ; Orellana Moraleda, Guillermo ; Islam, Mohammad N. ; Bhattacharya, Jahar ; Bhattacharya, Sunita ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | Elsevier | 2020-11-24This work explores the potential for strategizing pulmonary surfactant (PS) for drug delivery over the respiratory air-liquid interface: the interfacial delivery. The efficacy of PS- and interface-assisted drug vehiculization was determined both[...]texto impreso
Echaide Torreguitar, Mercedes ; Autilio, Chiara ; Arroyo, Raquel ; Pérez Gil, Jesús | Elsevier | 2017-09Pulmonary surfactant is a complex of lipids and proteins assembled and secreted by the alveolar epithelium into the thin layer of fluid coating the respiratory surface of lungs. There, surfactant forms interfacial films at the airwater interface[...]texto impreso
Autilio, Chiara ; Echaide Torreguitar, Mercedes ; Shankar-Aguilera, Shivani ; Bragado Herrero, Rafael ; Amidani, Davide ; Salomone, Fabrizio ; Pérez-Gil, Jesús ; De Luca, Daniele | American Thoracic Society | 2020-04-20Rationale. No in vivo data are available about the effect of meconium on human surfactant in the early stages of severe meconium aspiration syndrome (MAS). Objectives. To characterize the changes in surfactant composition, function and structure[...]texto impreso
De Luca, Daniele ; Shankar-Aguilera, Shivani ; Autilio, Chiara ; Raschetti, Roberto ; Vedovelli, Luca ; Fitting, Catherine ; Payré, Christine ; Jeammet, Louise ; Pérez Gil, Jesús ; Cogo, Paola E. ; Carnielli, Virgilio P. ; Lambeau, Gérard ; Touqui, Lhoussaine | American Physiological Society | 2020-06-25Secreted phospholipase A2 hydrolyzes surfactant phospholipids and is crucial for the inflammatory cascade; preterm neonates are treated with exogenous surfactant, but the interaction between surfactant and phospholipase is unknown. We hypothesiz[...]texto impreso
Pulmonary surfactant (PS) is a lipid-protein complex essential to stabilise the delicate structure of mammalian alveoli along with successive compression-expansion respiratory cycles. To do so, surfactant reduces dramatically surface tension at [...]
