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Yazicioglu, Tolga ; Mühlfeld, Christian ; Autilio, Chiara ; Huang, Cheng-Kai ; Bär, Christian ; Dittrich-Breiholz, Oliver ; Thum, Thomas ; Pérez Gil, Jesús ; Schmiedl, Andreas ; Brandenberger, Christina | American Physiological Society | 2020-10-14Morbidity and mortality rates in acute lung injury (ALI) increase with age. As alveolar epithelial type II cells (AE2) are crucial for lung function and repair, we hypothesized that aging promotes senescence in AE2 and contributes to the severit[...]texto impreso
To consider the lung as a target for drug delivery and to optimise strategies directed at the pulmonary route, it is essential to consider the role of pulmonary surfactant, a thin lipid–protein film lining the respiratory surface of mammalian lu[...]texto impreso
Backer, Lynn de ; Cerrada, Alejandro ; Pérez Gil, Jesús ; Smedt, Stefaan C. de ; Raemdonck, Koen | Elsevier | 2015Many pathologies of the respiratory tract are inadequately treated with existing small molecule-based therapies. The emergence of RNA interference (RNAi) enables the post-transcriptional silencing of key molecular disease factors that cannot rea[...]texto impreso
Oeo-Santos, Carmen ; López Rodríguez, Juan C. ; García-Mouton, Cristina ; San Segundo-Acosta, Pablo ; Jurado, Aurora ; Moreno-Aguilar, Carmen ; García-Álvarez, Begoña ; Pérez Gil, Jesús ; Villalba, Mayte ; Barderas Manchado, Rodrigo ; Cruz Rodríguez, Antonio | Elsevier | 2020-03-04Ole e 7 allergen from Olea europaea pollen possesses a major clinical relevance because it produces severe symptoms, such as anaphylaxis, in allergic patients exposed to high olive pollen counts. Ole e 7 is a non-specific lipid transfer protein [...]texto impreso
The respiratory surface in the mammalian lung is stabilized by pulmonary surfactant, a membrane-based system composed of multiple lipids and specific proteins, the primary function of which is to minimize the surface tension at the alveolar air–[...]texto impreso
Bañares Hidalgo, Ángeles ; Pérez Gil, Jesús ; Estrada, Pilar | Plublic Library of Science (PLOS) | 2016-07-05Assembly of pulmonary surfactant lipid-protein complexes depends on conformational changes coupled with proteolytic maturation of proSP-B, the precursor of pulmonary surfactant protein B (SP-B), along the surfactant biogenesis pathway in pneumoc[...]texto impreso
Roldán López, Nuria ; Pérez Gil, Jesús ; Morrow, Michael R. ; García Álvarez, Begoña | Elsevier | 2017-08-22Lung surfactant (LS) is an essential system supporting the respiratory function. Cholesterol can be deleterious for LS function, a condition that is reversed by the presence of the lipopeptide SP-C. In this work, the structure of LS-mimicking me[...]texto impreso
Roldán López, Nuria ; Nyholm, Thomas K. M. ; Slotte, J. Peter ; Pérez Gil, Jesús ; García Álvarez, Begoña | BIOPHYSICAL SOCIETY | 2016-10-18To allow breathing and prevent alveolar collapse, lung surfactant (LS) develops a complex membranous system at the respiratory surface. LS is defined by a specific protein and lipid composition, including saturated and unsaturated phospholipid s[...]texto impreso
Carravilla, Pablo ; Cruz Rodríguez, Antonio ; Martín-Ugarte, Itziar ; Oar-Arteta, Itziar R. ; Torralba, Johanna ; Apellaniz, Beatriz ; Pérez Gil, Jesús ; Requejo Isidro, José ; Huarte, Nerea ; Nieva, José L. | BIOPHYSICAL SOCIETY | 2017-09-19Membrane fusion induced by the envelope glycoprotein enables the intracellular replication of HIV-1; hence, this process constitutes a major target for antiretroviral compounds. It has been proposed that peptides having propensity to interact wi[...]texto impreso
Hidalgo, Alberto ; Salomone, Fabrizio ; Fresno, Nieves ; Orellana Moraleda, Guillermo ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | American Chemical Society | 2017Pulmonary surfactant is a crucial system to stabilize the respiratory air-liquid interface. Furthermore, pulmonary surfactant has been proposed as an effective method for targeting drugs to the lungs. However, few studies have examined in detail[...]texto impreso
Arroyo, Raquel ; Echaide Torreguitar, Mercedes ; Moreno Herrero, Fernando ; Pérez Gil, Jesús ; Kingma, Paul S. | Elsevier | 2020-04-20Surfactant Protein D (SP-D) is a collectin protein that participates in the innate immune defense of the lungs. SPD mediates the clearance of invading microorganisms by opsonization, aggregation or direct killing, which are lately removed by mac[...]texto impreso
Huarte, Nerea ; Carravilla, Pablo ; Cruz Rodríguez, Antonio ; Lorizate, Maier ; Nieto-Garay, Jon A. ; Kräusslich, Hans-Georg ; Pérez Gil, Jesús ; Requejo Isidro, José ; Nieva, José L. | Nature Publishing Group | 2016The chemical composition of the human immunodeficiency virus type 1 (HIV-1) membrane is critical for fusion and entry into target cells, suggesting that preservation of a functional lipid bilayer organization may be required for efficient infect[...]texto impreso
Lemke, Angela ; Castillo-Sánchez, José Carlos ; Prodinger, Florian ; Ceranic, Asja ; Hennerbichler-Lugscheider, Simone ; Pérez Gil, Jesús ; Redl, Heinz ; Wolbank, Susanne | Nature Publishing Group | 2017-07-25Pulmonary surfactant (PS) reduces surface tension at the air-liquid interface in the alveolar epithelium of the lung, which is required for breathing and for the pulmonary maturity of the developing foetus. However, the origin of PS had never be[...]texto impreso
López-Rodríguez, Elena ; Pascual, Alicia ; Arroyo, Raquel ; Floros, Joanna ; Pérez Gil, Jesús | BIOPHYSICAL SOCIETY | 2016-08Pulmonary surfactant is a lipoprotein complex that reduces surface tension to prevent alveolar collapse and contributes to the protection of the respiratory surface from the entry of pathogens. Surfactant protein A (SP-A) is a hydrophilic glycop[...]texto impreso
Olmeda Lozano, Bárbara ; García Álvarez, Begoña ; Gómez, Manuel J. ; Martínez Calle, Marta ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | Federation of American Societies for Experimental Biology | 2017Surfactant protein B (SP-B), from the saposin-like family of proteins, is essential to facilitate the formation and proper performance of surface active films at the air-liquid interface of mammalian lungs, and lack of or deficiency in this prot[...]
