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Autor Pérez Gil, Jesús |
Documentos disponibles escritos por este autor (33)
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Guagliardo, Roberta ; Merckx, Pieterjan ; Zamborlin, Agata ; Backer, Lynn de ; Echaide Torreguitar, Mercedes ; Pérez Gil, Jesús ; Smedt, Stefaan C. de ; Raemdonck, Koen | MDPI | 2019-08-23Two decades since the discovery of the RNA interference (RNAi) pathway, we are now witnessing the approval of the first RNAi-based treatments with small interfering RNA (siRNA) drugs. Nevertheless, the widespread use of siRNA is limited by vario[...]texto impreso
Roldán López, Nuria ; Goormaghtigh, Erik ; Pérez Gil, Jesús ; García Álvarez, Begoña | Elsevier | 2015-01Surfactant protein C (SP-C) has been regarded as the most specific protein linked to development of mammalian lungs, and great efforts have been done to understand its structure–function relationships. Previous evidence has outlined the importan[...]texto impreso
Cerrada, Alejandro ; Haller, Thomas ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | Cross Mark | 2015-12Pulmonary surfactant (PS) is an essential complex of lipids and specific proteins synthesized in alveolar type II pneumocytes, where it is assembled and stored intracellularly as multilayered organelles known as lamellar bodies (LBs). Once secre[...]texto impreso
Raesch, Simon Sebastian ; Tenzer, Stefan ; Storck, Wiebke ; Rurainski, Alexander ; Selzer, Dominik ; Ruge, Christian Arnold ; Pérez Gil, Jesús ; Schaefer, Ulrich Friedrich ; Lehr, Claus Michael | ACS | 2015-11-16Pulmonary surfactant (PS) constitutes the first line of host defense in the deep lung. Because of its high content of phospholipids and surfactant specific proteins, the interaction of inhaled nanoparticles (NPs) with the pulmonary surfactant la[...]texto impreso
Hidalgo Román, Alberto ; García-Mouton, Cristina ; Autilio, Chiara ; Carravilla, Pablo ; Orellana Moraleda, Guillermo ; Islam, Mohammad N. ; Bhattacharya, Jahar ; Bhattacharya, Sunita ; Cruz Rodríguez, Antonio ; Pérez Gil, Jesús | Elsevier | 2020-11-24This work explores the potential for strategizing pulmonary surfactant (PS) for drug delivery over the respiratory air-liquid interface: the interfacial delivery. The efficacy of PS- and interface-assisted drug vehiculization was determined both[...]texto impreso
Pulmonary surfactant is a membrane-based lipid-protein system essential for the process of breathing, which coats and stabilizes the whole respiratory surface and possesses exceptional biophysical properties. It constitutes the first barrier aga[...]texto impreso
Pulmonary surfactant is a lipid–protein complex that lines and stabilizes the respiratory interface in the alveoli, allowing for gas exchange during the breathing cycle. At the same time, surfactant constitutes the first line of lung defense aga[...]texto impreso
Martínez Calle, Marta ; Prieto, Manuel ; Olmedo, Barbara ; Fedorov, Aleksander ; Loura, Luís M.S. ; Pérez Gil, Jesús | Elsevier | 2020-02-15Surfactant protein SP-B is absolutely required for the generation of functional pulmonary surfactant, a unique network of multilayered membranes, which stabilizes the respiratory air-liquid interface. It has been proposed that SP-B assembles int[...]texto impreso
Echaide Torreguitar, Mercedes ; Autilio, Chiara ; Arroyo, Raquel ; Pérez Gil, Jesús | Elsevier | 2017-09Pulmonary surfactant is a complex of lipids and proteins assembled and secreted by the alveolar epithelium into the thin layer of fluid coating the respiratory surface of lungs. There, surfactant forms interfacial films at the airwater interface[...]texto impreso
Hobi, Nina ; Giolabi, Michael ; Olmeda Lozano, Bárbara ; Miklavc, Pika ; Felder, Edward ; Walter, Paul ; Dietl, Paul ; Frick, Manfred ; Pérez Gil, Jesús ; Haller, Thomas | Elsevier | 2016-08The molecular basis involving adsorption of pulmonary surfactant at the respiratory air–liquid interface and the specific roles of the surfactant proteins SP-B and SP-C in this process have not been completely resolved. The reasons might be foun[...]texto impreso
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López-Rodríguez, Juan C. ; Barderas Manchado, Rodrigo ; Echaide Torreguitar, Mercedes ; Pérez Gil, Jesús ; Villalba, Mayte ; Batanero Cremades, Eva ; Cruz Rodríguez, Antonio | American Chemical Society | 2016-10-25Aeroallergens are airborne substances?mainly proteins?capable of triggering Th2-immune responses in respiratory allergies. They enter into the body through the upper airways, reaching the mucosa afterward. Mucosae lining at the luminal side cons[...]texto impreso
Surfactant dysfunction during over-expression of TGF-?1 precedes profibrotic lung remodeling in vivo
López Rodríguez, Elena ; Boden, Caroline ; Echaide Torreguitar, Mercedes ; Pérez Gil, Jesús ; Kolb, Martin ; Gauldie, Jack ; Maus, Ulrich A. ; Ochs, Matthias ; Knudsen, Lars | American Physiological Society | 2016-06Surfactant dysfunction during overexpression of TGF-1 precedes profibrotic lung remodeling in vivo. Am J Physiol Lung Cell Mol Physiol 310: L1260 –L1271, 2016. First published April 22, 2016; doi:10.1152/ajplung.00065.2016.— Transforming growth [...]texto impreso
De Luca, Daniele ; Shankar-Aguilera, Shivani ; Autilio, Chiara ; Raschetti, Roberto ; Vedovelli, Luca ; Fitting, Catherine ; Payré, Christine ; Jeammet, Louise ; Pérez Gil, Jesús ; Cogo, Paola E. ; Carnielli, Virgilio P. ; Lambeau, Gérard ; Touqui, Lhoussaine | American Physiological Society | 2020-06-25Secreted phospholipase A2 hydrolyzes surfactant phospholipids and is crucial for the inflammatory cascade; preterm neonates are treated with exogenous surfactant, but the interaction between surfactant and phospholipase is unknown. We hypothesiz[...]