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National Academy of Sciences |
Documentos disponibles de esta editorial (27)
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Brutsaert, Tom D. ; Kiyamu, Melisa ; Elias Revollendo, Gianpietro ; Isherwood, Jenna L. ; Lee, Frank S. ; Rivera-Ch, Maria ; Leon-Velarde, Fabiola ; Ghosh, Sudipta ; Bigham, Abigail W. | National Academy of Sciences | 2019-12-06T21:02:54ZHighland native Andeans have resided at altitude for millennia. They display high aerobic capacity (VO2max) at altitude, which may be a reflection of genetic adaptation to hypoxia. Previous genomewide (GW) scans for natural selection have nomin[...]![]()
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Tejada, J.V. ; Flynn, J.J. ; Antoine, P.-O. ; Pacheco, V. ; Salas-Gismondi, R. ; Cerling, T.E. | National Academy of Sciences | 2020-12-14T16:10:17ZClosed-canopy rainforests are important for climate (influencing atmospheric circulation, albedo, carbon storage, etc.) and ecology (harboring the highest biodiversity of continental regions). Of all rainforests, Amazonia is the world's most div[...]![]()
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Defrance, Dimitri ; Ramstein, Gilles ; Charbit, Sylvie ; Vrac, Mathieu ; Moise Famien, Adjoua ; Sultan, Benjamin ; Swingedouw, Didier ; Dumas, Christophe ; Gemenne, François ; Álvarez Solas, Jorge ; Vanderlinden, Jean-Paul | National Academy of Sciences | 2017-06-20The acceleration of ice sheet melting has been observed over the last few decades. Recent observations and modeling studies have suggested that the ice sheet contribution to future sea level rise could have been underestimated in the latest Inte[...]![]()
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Gracia Téllez, Ana ; Arsuaga, Juan Luis ; Martínez Mendizábal, Ignacio ; Lorenzo Merino, Carlos ; Carretero, José Miguel ; Bermúdez de Castro, José María ; Carbonell i Roura, Eudald | National Academy of Sciences | 2009-04-21We report here a previously undescribed human Middle Pleistocene immature specimen, Cranium 14, recovered at the Sima de los Huesos (SH) site (Atapuerca, Spain), that constitutes the oldest evidence in human evolution of a very rare pathology in[...]![]()
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Van den Broeck, F. ; Savill, N.J. ; Imamura, H. ; Sanders, M. ; Maes, I. ; Cooper, S. ; Mateus, D. ; Jara, M. ; Adaui, V. ; Arevalo, J. ; Llanos-Cuentas, A. ; Garcia, L. ; Cupolillo, E. ; Miles, M. ; Berriman, M. ; Schnaufer, A. ; Cotton, J.A. ; Dujardin, J.-C. | National Academy of Sciences | 2020-12-14T16:10:23ZThe tropical Andes are an important natural laboratory to understand speciation in many taxa. Here we examined the evolutionary history of parasites of the Leishmania braziliensis species complex based on whole-genome sequencing of 67 isolates f[...]![]()
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Caramanica, A. ; Mesia, L.H. ; Morales, C.R. ; Huckleberry, G. ; Luis Jaime Castillo, B. ; Quilter, J. | National Academy of Sciences | 2020-12-14T16:06:12ZEl Niño-Southern Oscillation has been treated as a disruptor of environmental and socioeconomic equilibrium both in ancient times and in modern-day Peru. Recent work in the coastal desert plain, known as the Pampa de Mocan, challenges this view [...]![]()
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Griffiths, Scott ; Mesarich, Carl-H. ; Saccomanno, Benedetta ; Vaisberg, Abraham ; De-Wit, Pierre-J. G. M. ; Cox, Russell ; Collemare, Jerome | National Academy of Sciences | 2019-02-06T14:45:34ZAnthraquinones are a large family of secondary metabolites (SMs) that are extensively studied for their diverse biological activities. These activities are determined by functional group decorations and the formation of dimers from anthraquinone[...]![]()
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Masanes, Lluís ; Muller, Markus P. ; Augusiak, Remigiusz ; Pérez García, David | National Academy of Sciences | 2013-10Does information play a significant role in the foundations of physics? Information is the abstraction that allows us to refer to the states of systems when we choose to ignore the systems themselves. This is only possible in very particular fra[...]![]()
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Valdiosera Morales, Cristina ; Günther, Torsten ; Vera-Rodríguez, Juan Carlos ; Ureña, Irene ; Iriarte, Eneko ; Rodríguez Varela, Ricardo ; Simões, Luciana G. ; Martínez-Sánchez, Rafael María ; Svensson, Emma ; Malmström, Helena ; Rodríguez, Laura ; Bermúdez de Castro, José María ; Carbonell i Roura, Eudald ; Alday Ruiz, Alfonso ; Hernández Vera, José Antonio ; Götherström, Anders ; Carretero, José Miguel ; Arsuaga, Juan Luis ; Smith, Colin I. ; Jakobsson, Mattias | National Academy of Sciences | 2018-03-12Population genomic studies of ancient human remains have shown how modern-day European population structure has been shaped by a number of prehistoric migrations. The Neolithization of Europe has been associated with large-scale migrations from [...]![]()
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van Dorp, Lucy ; Lowes, Sara ; Weigel, Jonathan L. ; Ansari-Pour, Naser ; López, Saioa ; Mendoza-Revilla, Javier ; Robinson, James A. ; Henrich, Joseph ; Thomas, Mark G. ; Nunn, Nathan ; Hellenthal, Garrett | National Academy of Sciences | 2019-07-04T16:59:36ZFew phenomena have had as profound or long-lasting consequences in human history as the emergence of large-scale centralized states in the place of smaller scale and more local societies. This study examines a fundamental, and yet unexplored, co[...]![]()
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Álvarez Solas, Jorge ; Robinson, Alexander James ; Montoya Redondo, María Luisa ; Ritz, Catherine | National Academy of Sciences | 2013-10-08Proxy data reveal the existence of episodes of increased deposition of ice-rafted detritus in the North Atlantic Ocean during the last glacial period interpreted as massive iceberg discharges from the Laurentide Ice Sheet. Although these have lo[...]![]()
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San Martín, Álvaro ; Rodriguez-Aliaga, Piere ; Molina, José Alejandro ; Martin, Andreas ; Bustamante, Carlos ; Báez, Mauricio | National Academy of Sciences | 2019-01-25T15:28:04ZATP-dependent proteases translocate proteins through a narrow pore for their controlled destruction. However, how a protein substrate containing a knotted topology affects this process remains unknown. Here, we characterized the effects of the t[...]![]()
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Sistiaga, Ainara ; Husain, Fatima ; Uribelarrea del Val, David ; Martín Perea, David ; Ferland, Troy ; Freeman, Katherine H. ; Diez-Martín, Fernando ; Baquedano, Enrique ; Mabulla, Audax ; Domínguez-Rodrigo, Manuel ; Summons, Roger E. | National Academy of Sciences | 2020-10-06Landscape-scale reconstructions of ancient environments within the cradle of humanity may reveal insights into the relationship between early hominins and the changing resources around them. Many studies of Olduvai Gorge during Pliocene–Pleistoc[...]![]()
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Gonzalez-Guarda, Erwin ; Petermann-Pichincura, Alia ; Tornero, Carlos ; Domingo Martínez, Laura ; Agustí, Jordi ; Pino, Mario ; Abarzúa, Ana M. ; Capriles, José M. ; Villavicencio, Natalia A. ; Labarca, Rafael ; Tolorza, Violeta ; Sevilla, Paloma ; Rivals, Florent | National Academy of Sciences | 2018-09-11Proboscideans are so-called ecosystem engineers and are considered key players in hypotheses about Late Pleistocene megafaunal extinctions. However, knowledge about the autoecology and chronology of the proboscideans in South America is still op[...]![]()
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Almendro-Vedia, Víctor G. ; Natale, Paolo ; Mell, Michael ; Bonneau, Stephanie ; Monroy Muñoz, Francisco ; Joubert, Frederic ; López-Montero, Iván | National Academy of Sciences | 2017ATP synthase is a rotating membrane protein that synthesizes ATP through proton-pumping activity across the membrane. To unveil the mechanical impact of this molecular active pump on the bending properties of its lipid environment, we have funct[...]![]()
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Kehdy, F.S.G. ; Gouveia, M.H. ; Machado, M. ; Magalhães, W.C.S. ; Horimoto, A.R. ; Horta, B.L. ; Moreira, R.G. ; Leal, T.P. ; Scliar, M.O. ; Soares-Souza, G.B. ; Rodrigues-Soares, F. ; Araújo, G.S. ; Zamudio, R. ; Sant Anna, H.P. ; Santos, H.C. ; Duarte, N.E. ; Fiaccone, R.L. ; Figueiredo, C.A. ; Silva, T.M. ; Costa, G.N.O. ; Beleza, S. ; Berg, D.E. ; Cabrera, L. ; Debortoli, G. ; Duarte, D. ; Ghirotto, S. ; Gilman, R.H. ; Gonçalves, V.F. ; Marrero, A.R. ; Muniz, Y.C. ; Weissensteiner, H. ; Yeager, M. ; Rodrigues, L.C. ; Barreto, M.L. ; Lima-Costa, M.F. ; Pereira, A.C. ; Rodrigues, M.R. ; Tarazona-Santos, E. | National Academy of Sciences | 2019-04-24T18:23:57ZWhile South Americans are underrepresented in human genomic diversity studies, Brazil has been a classical model for population genetics studies on admixture.We present the results of the EPIGEN Brazil Initiative, the most comprehensive up-to-da[...]![]()
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Salas Quiroga, Adán de ; Díaz Alonso, Javier ; García-Rincón, Daniel ; Remmers, Floortje ; Vega, David ; Gómez Cañas, María ; Lutz, Beat ; Guzmán, Manuel ; Galve Roperh, Ismael | National Academy of Sciences | 2015-11The CB1 cannabinoid receptor, the main target of ?9 -tetrahydrocannabinol (THC), the most prominent psychoactive compound of marijuana, plays a crucial regulatory role in brain development as evidenced by the neurodevelopmental consequences of i[...]![]()
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Yau, Audrey M. ; Bender, Michael L. ; Robinson, Alexander James ; Brook, Edward J. | National Academy of Sciences | 2016-08-30The Eemian (last interglacial, 130-115 ka) was likely the warmest of all interglacials of the last 800 ka, with summer Arctic temperatures 3-5 degrees C above present. Here, we present improved Eemian climate records from central Greenland, reco[...]![]()
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Fernández Pérez, Luis Antonio ; Martín Mayor, Víctor ; Muñoz Sudupe, Antonio | National Academy of Sciences | 2017-02-21We have performed a very accurate computation of the non-equilibrium fluctuation- dissipation ratio for the 3D Edwards-Anderson Ising spin glass, by means of large-scale simulations on the special-purpose computers Janus and Janus II. This ratio[...]![]()
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Fernández Pérez, Luis Antonio ; Martín Mayor, Víctor ; Muñoz Sudupe, Antonio ; otros, ... | National Academy of Sciences | 2017-02-21The unifying feature of glass formers (such as polymers, supercooled liquids, colloids, granulars, spin glasses, superconductors, ...) is a sluggish dynamics at low temperatures. Indeed, their dynamics is so slow that thermal equilibrium is neve[...]![]()
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Valdiosera Morales, Cristina ; García Garitagoitia, José Luis ; García García, Nuria ; Doabrio Villarejo, Ignacio ; Thomas, Mark G. ; Hänni, Catherine ; Arsuaga, Juan Luis ; Barnes, Ian ; Hofreiter, Michael ; Orlando, Ludovic ; Götherström, Anders | National Academy of Sciences | 2008The endangered brown bear populations (Ursus arctos) in Iberia have been suggested to be the last fragments of the brown bear population that served as recolonization stock for large parts of Europe during the Pleistocene. Conservation efforts a[...]![]()
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The image that best expresses Darwin’s thinking is the tree of life. However, Darwin’s human evolutionary tree lacked almost everything because only the Neanderthals were known at the time and they were considered one extreme expression of our o[...]![]()
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Wijnker, Erik ; Harashima, Hirofumi ; Müller, Katja ; Parra Núñez, Pablo ; Bastiaan de Snoo, C. ; Van de Belt, José ; Dissmeyer, Nico ; Bayer, Martin ; Pradillo, Mónica ; Schnittger, Arp | National Academy of Sciences | 2019-06Little is known how patterns of cross-over (CO) numbers and distribution during meiosis are established. Here, we reveal that cyclin-dependent kinase A;1 (CDKA;1), the homolog of human Cdk1 and Cdk2, is a major regulator of meiotic recombination[...]![]()
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Stembridge, Mike ; Williams, Alexandra M. ; Gasho, Christopher ; Dawkins, Tony G. ; Drane, Aimee ; Villafuerte, Francisco C. ; Levine, Benjamin D. ; Shave, Rob ; Ainslie, Philip N. | National Academy of Sciences | 2019-08-08T15:23:47ZIn contrast to Andean natives, high-altitude Tibetans present with a lower hemoglobin concentration that correlates with reproductive success and exercise capacity. Decades of physiological and genomic research have assumed that the lower hemogl[...]![]()
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Stembridge, Mike ; Williams, Alexandra M. ; Gasho, Christopher ; Dawkins, Tony G. ; Drane, Aimee ; Villafuerte, Francisco C. ; Levine, Benjamin D. ; Shave, Rob ; Ainslie, Philip N. | National Academy of Sciences | 2019-12-06T20:57:47ZIn contrast to Andean natives, high-altitude Tibetans present with a lower hemoglobin concentration that correlates with reproductive success and exercise capacity. Decades of physiological and genomic research have assumed that the lower hemogl[...]![]()
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Fernández Pérez, Luis Antonio ; Martín Mayor, Víctor ; Muñoz Sudupe, Antonio ; Seoane Bartolomé, Beatriz ; Yllanes Mosquera, David ; et al, ... | National Academy of Sciences | 2012-04-24Spin glasses are a longstanding model for the sluggish dynamics that appear at the glass transition. However, spin glasses differ from structural glasses in a crucial feature: they enjoy a time reversal symmetry. This symmetry can be broken by a[...]